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甘氨醯-脯氨醯-羥脯氨酸

编辑链接
维基百科，自由的百科全书
（重定向自C12H19N3O5）
甘氨醯-脯氨醯-羥脯氨酸
识别信息
  • (2S,4R)-1-[(2S)-1-(2-aminoacetyl)pyrrolidine-2-carbonyl]-4-hydroxypyrrolidine-2-carboxylic acid
CAS号2239-67-0
PubChem CID
ChemSpider
UNII
ChEBI
化学信息
化学式C12H19N3O5
摩尔质量285.30 g·mol−1
3D模型（JSmol）
  • C1C[C@H](N(C1)C(=O)CN)C(=O)N2C[C@@H](C[C@H]2C(=O)O)O
  • InChI=1S/C12H19N3O5/c13-5-10(17)14-3-1-2-8(14)11(18)15-6-7(16)4-9(15)12(19)20/h7-9,16H,1-6,13H2,(H,19,20)/t7-,8+,9+/m1/s1
  • Key:SZEOBSAZWJLOGY-VGMNWLOBSA-N

甘氨醯-脯氨醯-羥脯氨酸（Gly-Pro-Hyp，三肽-29）是一種源自膠原蛋白的三肽。Gly-Pro-Hyp的重複單元構成了膠原蛋白的主要部分，而Gly-Pro-Hyp可以輕易地透過膠原蛋白的部分水解來製備。與Hyp-Gly和Pro-Hyp等其他源自膠原蛋白的小分子二肽一樣，Gly-Pro-Hyp被廣泛應用於護膚產品中，有時也作為膳食補充劑內服，因為它容易被皮膚吸收並能刺激成纖維細胞合成膠原蛋白，從而有助於傷口癒合，並可能幫助減少衰老跡象。市面上標榜含有「膠原蛋白」的膳食補充劑，通常實際上含有的是膠原蛋白部分水解所產生的低分子量膠原蛋白肽，因為它們比膠原蛋白本身更容易被人體吸收。[1][2][3][4][5][6][7][8]

參見

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參考文獻

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  1. ^ Inoue N, Sugihara F, Wang X. Ingestion of bioactive collagen hydrolysates enhance facial skin moisture and elasticity and reduce facial ageing signs in a randomised double-blind placebo-controlled clinical study. Journal of the Science of Food and Agriculture. 2016-09-01, 96 (12): 4077–4081. Bibcode:2016JSFA...96.4077I. PMID 26840887. doi:10.1002/jsfa.7606. 
  2. ^ Yazaki M, Ito Y, Yamada M, Goulas S, Teramoto S, Nakaya MA, Ohno S, Yamaguchi K. Oral Ingestion of Collagen Hydrolysate Leads to the Transportation of Highly Concentrated Gly-Pro-Hyp and Its Hydrolyzed Form of Pro-Hyp into the Bloodstream and Skin. Journal of Agricultural and Food Chemistry. 2017-03-01, 65 (11): 2315–2322. Bibcode:2017JAFC...65.2315Y. PMID 28244315. doi:10.1021/acs.jafc.6b05679. 
  3. ^ Kim DU, Chung HC, Choi J, Sakai Y, Lee BY. Oral Intake of Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study. Nutrients. 2018-06-01, 10 (7): 826. PMC 6073484 可免费查阅. PMID 29949889. doi:10.3390/nu10070826 可免费查阅. 
  4. ^ Chae M, Bae IH, Lim SH, Jung K, Roh J, Kim W. AP Collagen Peptides Prevent Cortisol-Induced Decrease of Collagen Type I in Human Dermal Fibroblasts. International Journal of Molecular Sciences. 2021-04-01, 22 (9): 4788. PMC 8125628 可免费查阅. PMID 33946465. doi:10.3390/ijms22094788 可免费查阅. 
  5. ^ Chae M, Moon CY, Lim SH, Yamashita Y, Yamada H, Ide M, Park CW, Roh J, Kim W. Oral Ingestion of AP Collagen Peptide Leads to Systemic Absorption of Gly-Pro-Hyp, Alleviating H2O2-Induced Dermal Fibroblast Aging. Journal of Medicinal Food. 2023-05-01, 26 (5): 299–306. PMID 37074675. doi:10.1089/jmf.2022.K.0149. 
  6. ^ Yang D, Liu Q, Xu Q, Zheng L, Zhang S, Lu S, Xiao G, Zhao M. Effects of collagen hydrolysates on UV-induced photoaging mice: Gly-Pro-Hyp as a potent anti-photoaging peptide. Food & Function. 2024-03-01, 15 (6): 3008–3022. PMID 38411396. doi:10.1039/d3fo04949c. 
  7. ^ Oztug M. Bioactive Peptide Profiling in Collagen Hydrolysates: Comparative Analysis Using Targeted and Untargeted Liquid Chromatography-Tandem Mass Spectrometry Quantification. Molecules. 2024-05-01, 29 (11): 2592. PMC 11173644 可免费查阅. PMID 38893467. doi:10.3390/molecules29112592 可免费查阅. 
  8. ^ Kim CE, Lee JS, Kim YH, Shin YC, Shin SK, Kwon EY. Effects of collagen tripeptide supplementation on oxidative stress and mitochondrial function in aging. Nutrition Research and Practice. 2025-12-01, 19 (6): 867–879. PMC 12688003 可免费查阅. PMID 41377595. doi:10.4162/nrp.2025.19.6.867. 
检索自“https://zh.wikipedia.org/w/index.php?title=甘氨醯-脯氨醯-羥脯氨酸&oldid=91931318”