鳞状细胞癌抗原-1

鳞状细胞癌抗原-1
已知的结构
PDB	直系同源搜索：PDBe RCSB
PDBID列表
	2ZV6、4ZK0、4ZK3
标识符
代号	SERPINB3
扩展标识	OMIM：600517；MGI：2683295；HomoloGene：130559；GeneCards：SERPINB3；OMA：SERPINB3 - orthologs
基因位置（人类）
染色体	18號染色體
终止	63,661,893 bp
基因位置（小鼠）
染色体	小鼠1号染色体
终止	107,011,236 bp
RNA表达模式
	Top expressed in
	olfactory zone of nasal mucosa; ; nasal epithelium; ; mucosa of paranasal sinus; ; epithelium of bronchus; ; bronchial epithelial cell; ; gingival epithelium; ; mucosa of pharynx;
	无数据
	查阅更多表达数据
	; ; ; ;
	查阅更多表达数据
基因本體
分子功能	virus receptor activity; 蛋白酶結合; cysteine-type endopeptidase inhibitor activity; peptidase inhibitor activity; serine-type endopeptidase inhibitor activity;
細胞組分	细胞核; 囊泡; cytoplasmic vesicle; 外排體; 細胞質; 細胞外區域; 細胞外空間; azurophil granule lumen;
生物學過程	旁分泌; positive regulation of cell population proliferation; 自分泌; negative regulation of catalytic activity; negative regulation of JUN kinase activity; positive regulation of endopeptidase activity; positive regulation of epithelial to mesenchymal transition; negative regulation of proteolysis; negative regulation of endopeptidase activity; positive regulation of cell migration; 病毒进入; negative regulation of peptidase activity; neutrophil degranulation;
	来源：Amigo / QuickGO
直系同源
	6317
	394252
	ENSG00000057149
	ENSMUSG00000058017
	P29508
	Q6UKZ0
	NM_006919
	NM_201376
	NP_008850
	NP_958764
	维基数据
檢視/編輯人類	檢視/編輯小鼠

鳞状细胞癌抗原-1（英語：Squamous cell carcinoma antigen-1，缩写SCCA-1、SCCA1，也称为肿瘤相关抗TA4、丝氨酸蛋白酶抑制剂家族B亚家族成员3，serpin family B member 3，缩写SERPINB3）是一个人类18号染色体上的基因，编码一种丝氨酸蛋白酶抑制剂蛋白，是鳞状细胞癌的肿瘤标志物^[5]^[6]。

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000057149 – Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000058017 – Ensembl, 2017年5月
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Schneider SS, Schick C, Fish KE, Miller E, Pena JC, Treter SD, Hui SM, Silverman GA. A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene. Proc Natl Acad Sci U S A. May 1995, 92 (8): 3147–51. Bibcode:1995PNAS...92.3147S. PMC 42122 . PMID 7724531. doi:10.1073/pnas.92.8.3147 .
^ Entrez Gene: SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3. [2023-04-10]. （原始内容存档于2010-12-05）.

外部链接

The MEROPS online database for peptidases and their inhibitors: I04.008^{[失效連結]}
醫學主題詞表（MeSH）：SERPINB3+protein,+human

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000057149 – Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000058017 – Ensembl, 2017年5月

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7724531-5] Schneider SS, Schick C, Fish KE, Miller E, Pena JC, Treter SD, Hui SM, Silverman GA. A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene. Proc Natl Acad Sci U S A. May 1995, 92 (8): 3147–51. Bibcode:1995PNAS...92.3147S. PMC 42122 . PMID 7724531. doi:10.1073/pnas.92.8.3147 .

[entrez-6] Entrez Gene: SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3. [2023-04-10]. （原始内容存档于2010-12-05）.

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