脂联素受体2

ADIPOR2
已知的结构
PDB	直系同源搜索：PDBe RCSB
PDBID列表
	3WXW
标识符
代号	ADIPOR2
扩展标识	OMIM：607946；MGI：93830；HomoloGene：56119；GeneCards：ADIPOR2；OMA：ADIPOR2 - orthologs
基因位置（人类）
染色体	12號染色體
终止	1,788,674 bp
基因位置（小鼠）
染色体	小鼠6号染色体
终止	119,394,665 bp
RNA表达模式
	Top expressed in
	C1 segment; ; right adrenal cortex; ; right lung; ; left adrenal gland; ; left adrenal cortex; ; epithelium of colon; ; hippocampus proper;
	Top expressed in
	lactiferous gland; ; transitional epithelium of urinary bladder; ; vestibular membrane of cochlear duct; ; epithelium of small intestine; ; epithelium of stomach; ; pyloric antrum; ; left lobe of liver; ; tunica adventitia of aorta;
	查阅更多表达数据
	无数据
基因本體
分子功能	adipokinetic hormone receptor activity; adiponectin binding; 金屬離子結合; 相同蛋白质结合; protein heterodimerization activity; signaling receptor activity;
細胞組分	integral component of membrane; 膜; intrinsic component of plasma membrane; 细胞膜;
生物學過程	positive regulation of glucose import; glucose homeostasis; response to nutrient; 脂質代謝; female pregnancy; adiponectin-activated signaling pathway; 脂肪酸代謝; vascular wound healing; 心脏发育; negative regulation of cell growth; fatty acid oxidation; hormone-mediated signaling pathway; regulation of fatty acid biosynthetic process; positive regulation of cold-induced thermogenesis;
	来源：Amigo / QuickGO
直系同源
	79602
	68465
	ENSG00000006831; ENSG00000285070
	ENSMUSG00000030168
	Q86V24
	Q8BQS5
	NM_024551; NM_001375363; NM_001375364; NM_001375365
	NM_197985; NM_001355692
	NP_078827; NP_001362292; NP_001362293; NP_001362294
	NP_932102; NP_001342621
	维基数据
檢視/編輯人類	檢視/編輯小鼠

脂联素受体2（英語：Adiponectin receptor 2，缩写ADIPOR2）是一种由人类基因 ADIPOR2 编码的蛋白质^[5]。

结构

ADIPOR2和G蛋白偶联受体（GPCRs）类似，都拥有7个跨膜结构域。但是ADIPOR1的七跨膜的位置与GPCRs相反，N-端在细胞内，C-端在细胞外，也不能与G蛋白相互作用^[5]。

功能

脂联素的受体，ADIPOR1和ADIPOR2，能应答球状或全长的脂联素信号，促使AMPK（英语：AMP-activated protein kinase）和PPAR-α（英语：Peroxisome proliferator-activated receptor alpha）配体活性增加，以及脂肪酸的氧化和葡萄糖摄取^[5]。

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000006831、ENSG00000285070 – Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000030168 – Ensembl, 2017年5月
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^5.0 ^5.1 ^5.2 Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature. June 2003, 423 (6941): 762–9. PMID 12802337. doi:10.1038/nature01705.

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000006831、ENSG00000285070 – Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000030168 – Ensembl, 2017年5月

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12802337-5] 5.0 ^5.1 ^5.2 Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature. June 2003, 423 (6941): 762–9. PMID 12802337. doi:10.1038/nature01705.

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