3-氟-4-甲基苯甲醛

3-氟-4-甲基苯甲醛
识别
CAS号	177756-62-6
PubChem	2774574
SMILES	CC1=C(C=C(C=C1)C=O)F;
性质
化学式	C8H7FO
摩尔质量	138.14 g·mol−1
外观	亮黄色液体
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

3-氟-4-甲基苯甲醛是一种有机氟化合物，化学式为C₈H₇FO。它可由4-甲基苯甲醛在乙腈中经10%氟气于0 °C氟化得到，^[1]或以3-氟-4-甲基苯甲酸为原料，经多步反应制得。^[2]它和乙氧羰基亚甲基三苯基磷在二氯甲烷中反应，可以得到(E)-3-(3-氟-4-甲基苯基)丙烯酸乙酯。^[3]

参考文献

^ ^1.0 ^1.1 Chambers R D, Sandford G, Trmcic J, Okazoe T. Elemental Fluorine. Part 21.1 Direct Fluorination of Benzaldehyde Derivatives. Organic Process Research and Development, 2008. 12 (2): 339-344. doi:10.1021/op700194r.
^ Khanna I K, Weier R M, Yu Y, et al. 1, 2-Diarylimidazoles as potent, cyclooxygenase-2 selective, and orally active antiinflammatory agents. Journal of medicinal chemistry, 1997, 40 (11): 1634-1647. doi:10.1021/jm9700225. "Step 1. To a solution of 3-fluoro-4-methylbenzoic acid ... give 11.41 g (86%) of the benzaldehyde as a yellow oil"
^ West T H, Walden D M, Taylor J E, et al. Catalytic enantioselective [2, 3]-rearrangements of allylic ammonium ylides: a mechanistic and computational study. Journal of the American Chemical Society, 2017, 139(12): 4366-4375. doi:10.1021/jacs.6b11851. p S57 "Ethyl (E)-3-(3-fluoro-4-methylphenyl)acrylate SI-30"

[Chambers-1] 1.0 ^1.1 Chambers R D, Sandford G, Trmcic J, Okazoe T. Elemental Fluorine. Part 21.1 Direct Fluorination of Benzaldehyde Derivatives. Organic Process Research and Development, 2008. 12 (2): 339-344. doi:10.1021/op700194r.

[2] Khanna I K, Weier R M, Yu Y, et al. 1, 2-Diarylimidazoles as potent, cyclooxygenase-2 selective, and orally active antiinflammatory agents. Journal of medicinal chemistry, 1997, 40 (11): 1634-1647. doi:10.1021/jm9700225. "Step 1. To a solution of 3-fluoro-4-methylbenzoic acid ... give 11.41 g (86%) of the benzaldehyde as a yellow oil"

[3] West T H, Walden D M, Taylor J E, et al. Catalytic enantioselective [2, 3]-rearrangements of allylic ammonium ylides: a mechanistic and computational study. Journal of the American Chemical Society, 2017, 139(12): 4366-4375. doi:10.1021/jacs.6b11851. p S57 "Ethyl (E)-3-(3-fluoro-4-methylphenyl)acrylate SI-30"

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