CEBPG

CEBPG
标识符
代号	CEBPG
扩展标识	OMIM：138972；MGI：104982；HomoloGene：1368；GeneCards：CEBPG；OMA：CEBPG - orthologs
基因位置（人类） 染色体 19號染色體 基因座 19q13.11 起始 33,373,685 bp 终止 33,382,686 bp
基因位置（小鼠） 染色体 小鼠7号染色体 基因座 7|7 B2 起始 34,745,847 bp 终止 34,755,998 bp
RNA表达模式 Bgee 人类 小鼠（直系同源） Top expressed in mucosa of colon mucosa of sigmoid colon muscle of thigh mucosa of transverse colon body of tongue gingival epithelium jejunal mucosa Top expressed in conjunctival fornix left colon 查阅更多表达数据 BioGPS 查阅更多表达数据
基因本體 分子功能 DNA结合 protein homodimerization activity DNA结合转录因子活性 DNA-binding transcription activator activity, RNA polymerase II-specific 转录因子结合 RNA polymerase II cis-regulatory region sequence-specific DNA binding 血浆蛋白结合 sequence-specific DNA binding protein heterodimerization activity DNA-binding transcription factor activity, RNA polymerase II-specific double-stranded DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding, bending 細胞組分 核质 细胞核 生物學過程 regulation of transcription, DNA-templated positive regulation of DNA repair positive regulation of DNA-binding transcription factor activity negative regulation of DNA-binding transcription factor activity transcription, DNA-templated enucleate erythrocyte differentiation 免疫反应 mRNA metabolic process B cell differentiation positive regulation of DNA binding positive regulation of transcription by RNA polymerase II natural killer cell mediated cytotoxicity transcription by RNA polymerase II liver development regulation of transcription by RNA polymerase II 来源：Amigo / QuickGO
直系同源 物種 人類 小鼠 Entrez 1054 12611 Ensembl ENSG00000153879 ENSMUSG00000056216 UniProt P53567 P53568 mRNA序列 NM_001806 ​NM_001252296 NM_009884 蛋白序列 NP_001239225 ​NP_001797 NP_034014 基因位置 Chr 19：33.37 – 33.38 Mb Chr 7：34.75 – 34.76 Mb PubMed查询
维基数据
檢視/編輯人類 檢視/編輯小鼠

CCAAT/增强子结合蛋白γ，简称C/EBP-γ或CEBPG是化学式为：C₆₉₄H₁₁₆₂O₂₃₁N₂₂₂S₃，一种在人体中由CEBPG基因编码的蛋白质。

C/EBP转录因子家族调节病毒和细胞CCAAT/增强子元件介导的转录。C/EBP蛋白包含bZIP区域，其特征在于蛋白质的C端一半中的两个基序：一个参与DNA结合的碱性区域和一个参与二聚化的亮氨酸拉链基序。 C/EBP家族由几种相关的蛋白质组成，即C/EBP-α、C/EBP-β、C/EBP-γ和C/EBP-δ，它们形成同源二聚体并相互形成异源二聚体。CEBPG可以与Fos合作以结合PRE-I增强子元件。

参见

• CCAAT/增强子结合蛋白

阅读

• Nishizawa M, Nagata S. cDNA clones encoding leucine-zipper proteins which interact with G-CSF gene promoter element 1-binding protein.. FEBS Lett. 1992, 299 (1): 36–8. PMID 1371974. S2CID 34097395. doi:10.1016/0014-5793(92)80094-W . 
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• Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899 . 
• Hattori T, Ohoka N, Inoue Y, et al. C/EBP family transcription factors are degraded by the proteasome but stabilized by forming dimer.. Oncogene. 2003, 22 (9): 1273–80. PMID 12618752. doi:10.1038/sj.onc.1206204 . 
• Newman JR, Keating AE. Comprehensive identification of human bZIP interactions with coiled-coil arrays.. Science. 2003, 300 (5628): 2097–101. Bibcode:2003Sci...300.2097N. PMID 12805554. S2CID 36715183. doi:10.1126/science.1084648. 
• Gerhard DS, Wagner L, Feingold EA, et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504. 
• Rual JF, Venkatesan K, Hao T, et al. Towards a proteome-scale map of the human protein-protein interaction network.. Nature. 2005, 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. PMID 16189514. S2CID 4427026. doi:10.1038/nature04209. 
• Mullins DN, Crawford EL, Khuder SA, et al. CEBPG transcription factor correlates with antioxidant and DNA repair genes in normal bronchial epithelial cells but not in individuals with bronchogenic carcinoma.. BMC Cancer. 2006, 5: 141. PMC 1310620 . PMID 16255782. doi:10.1186/1471-2407-5-141. 

外部链接

• 醫學主題詞表（MeSH）：CEBPG+protein,+human
• Human CEBPG genome location and CEBPG gene details page in the UCSC Genome Browser.