CTLA-4

細胞毒性T淋巴細胞相關抗原4
已知的结构
PDB	直系同源搜索：PDBe RCSB
PDBID列表
	3OSK、1AH1、1H6E、1I85、1I8L、2X44、3BX7
标识符
代号	CTLA4
扩展标识	OMIM：123890；MGI：88556；HomoloGene：3820；GeneCards：CTLA4；OMA：CTLA4 - orthologs
基因位置（人类）
染色体	2號染色體
终止	203,873,965 bp
基因位置（小鼠）
染色体	小鼠1号染色体
终止	60,954,991 bp
RNA表达模式
	Top expressed in
	buccal mucosa cell; ; pancreatic epithelial cell; ; pancreatic ductal cell;
	Top expressed in
	primary oocyte; ; zone of skin;
	查阅更多表达数据
	查阅更多表达数据
基因本體
分子功能	血浆蛋白结合;
細胞組分	细胞质的核周区域; integral component of membrane; clathrin-coated endocytic vesicle; 细胞膜; 高尔基体; 膜; external side of plasma membrane; protein complex involved in cell adhesion; integral component of plasma membrane;
生物學過程	B cell receptor signaling pathway; T cell costimulation; negative regulation of B cell proliferation; 适应性免疫; negative regulation of regulatory T cell differentiation; 免疫反应; cellular response to DNA damage stimulus; immune system process; positive regulation of apoptotic process; negative regulation of immune response; negative regulation of T cell proliferation; regulation of regulatory T cell differentiation; regulation of T cell proliferation; T cell receptor signaling pathway;
	来源：Amigo / QuickGO
直系同源
	1493
	12477
	ENSG00000163599
	ENSMUSG00000026011
	P16410
	P09793
	NM_001037631; NM_005214
	NM_001281976; NM_009843
	NP_001032720; NP_005205
	NP_001268905; NP_033973
	维基数据
檢視/編輯人類	檢視/編輯小鼠

CTLA4又稱CTLA-4（細胞毒性T淋巴細胞相關抗原4，cytotoxic T-lymphocyte-associated protein 4）或CD152（分化群152），是一种蛋白质受体^[5]。CTLA-4蛋白由小鼠的Ctla4^[6]和人类的CTLA4基因编码^[7]。CTLA-4于1991年首次被發現^[8]。

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000163599 – Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000026011 – Ensembl, 2017年5月
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ De-novo and acquired resistance to immune checkpoint targeting. The Lancet. Oncology. December 2017, 18 (12): e731–e741. PMID 29208439. doi:10.1016/s1470-2045(17)30607-1.
^ A new member of the immunoglobulin superfamily--CTLA-4. Nature. 1987, 328 (6127): 267–70. Bibcode:1987Natur.328..267B. PMID 3496540. doi:10.1038/328267a0.
^ Human Ig superfamily CTLA-4 gene: chromosomal localization and identity of protein sequence between murine and human CTLA-4 cytoplasmic domains. European Journal of Immunology. December 1988, 18 (12): 1901–5. PMID 3220103. doi:10.1002/eji.1830181206.
^ Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science. November 1995, 270 (5238): 985–8. Bibcode:1995Sci...270..985W. JSTOR 2888113. PMID 7481803. doi:10.1126/science.270.5238.985.

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000163599 – Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000026011 – Ensembl, 2017年5月

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[:0-5] De-novo and acquired resistance to immune checkpoint targeting. The Lancet. Oncology. December 2017, 18 (12): e731–e741. PMID 29208439. doi:10.1016/s1470-2045(17)30607-1.

[pmid3496540-6] A new member of the immunoglobulin superfamily--CTLA-4. Nature. 1987, 328 (6127): 267–70. Bibcode:1987Natur.328..267B. PMID 3496540. doi:10.1038/328267a0.

[pmid3220103-7] Human Ig superfamily CTLA-4 gene: chromosomal localization and identity of protein sequence between murine and human CTLA-4 cytoplasmic domains. European Journal of Immunology. December 1988, 18 (12): 1901–5. PMID 3220103. doi:10.1002/eji.1830181206.

[Waterhouse_1995-8] Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science. November 1995, 270 (5238): 985–8. Bibcode:1995Sci...270..985W. JSTOR 2888113. PMID 7481803. doi:10.1126/science.270.5238.985.

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