CXCL9

CXCL9
标识符
代号	CXCL9
扩展标识	OMIM：601704；MGI：1352449；HomoloGene：1813；GeneCards：CXCL9；OMA：CXCL9 - orthologs
基因位置（人类）
染色体	4號染色體
终止	76,007,509 bp
基因位置（小鼠）
染色体	小鼠5号染色体
终止	92,475,938 bp
RNA表达模式
	Top expressed in
	epithelium of nasopharynx; ; olfactory zone of nasal mucosa; ; palpebral conjunctiva;
	Top expressed in
	subcutaneous adipose tissue; ; left lobe of liver; ; tunica adventitia of aorta;
	查阅更多表达数据
	查阅更多表达数据
基因本體
分子功能	細胞因子活性; CXCR3 chemokine receptor binding; chemokine activity; 血浆蛋白结合;
細胞組分	細胞外區域; external side of plasma membrane; 細胞外空間; 胞內;
生物學過程	G protein-coupled receptor signaling pathway; chemokine-mediated signaling pathway; cell-cell signaling; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of cAMP-mediated signaling; 趨化性; positive regulation of leukocyte chemotaxis; cellular defense response; positive regulation of myoblast fusion; response to lipopolysaccharide; regulation of cell population proliferation; positive regulation of myoblast differentiation; defense response to virus; 免疫反应; 訊息傳遞; defense response; inflammatory response; T cell chemotaxis; antimicrobial humoral immune response mediated by antimicrobial peptide; regulation of signaling receptor activity; adenylate cyclase-activating G protein-coupled receptor signaling pathway; response to bacterium; neutrophil chemotaxis; leukocyte chemotaxis; cellular response to lipopolysaccharide;
	来源：Amigo / QuickGO
直系同源
	4283
	17329
	ENSG00000138755
	ENSMUSG00000029417
	Q07325
	P18340
	NM_002416
	NM_008599
	NP_002407
	NP_032625
	维基数据
檢視/編輯人類	檢視/編輯小鼠

CXCL9（英語：Chemokine (C-X-C motif) ligand 9）化学式为C₅₀₉H₈₇₇O₁₄₈N₁₅₉S₄^[5]是一小分子的细胞因子属于CXC趋化因子家族，又被称作“干扰素伽玛诱导的单核细胞因子”（Monokine induced by gamma interferon, MIG）^[6]。CXCL9是T细胞趋化因子^[6]。干扰素伽玛诱导CXCL9的表达。人类的CXCL9与CXCL10，CXCL11的基因相邻聚集在第四染色体上^[7]。CXCL9，CXCL10, CXCL11结合趋化因子受体CXCR3而起其细胞趋化作用^[8]^[9]。

参见

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000138755 – Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000029417 – Ensembl, 2017年5月
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Expasy - ProtParam. web.expasy.org. [2026-02-10].
^ ^6.0 ^6.1 Liao F, Rabin RL, Yannelli JR, Koniaris LG, Vanguri P, Farber JM. Human Mig chemokine: biochemical and functional characterization. J Exp Med. 1995 Nov 1;182(5):1301-14.
^ Lee HH, Farber JM. Localization of the gene for the human MIG cytokine on chromosome 4q21 adjacent to INP10 reveals a chemokine "mini-cluster". Cytogenet Cell Genet. 1996;74(4):255-8.
^ Loetscher M, Gerber B, Loetscher P, Jones SA, Piali L, Clark-Lewis I, Baggiolini M, Moser B. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. J Exp Med. 1996 Sep 1;184(3):963-9.
^ Weng Y, Siciliano SJ, Waldburger KE, Sirotina-Meisher A, Staruch MJ, Daugherty BL, Gould SL, Springer MS, DeMartino JA. Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors. J Biol Chem. 1998 Jul 17;273(29):18288-91.

外部链接

Charo IF, Ransohoff RM. The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med. 2006 Feb 9;354(6):610-21.（页面存档备份，存于互联网档案馆）

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000138755 – Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000029417 – Ensembl, 2017年5月

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Expasy - ProtParam. web.expasy.org. [2026-02-10].

[liao-6] 6.0 ^6.1 Liao F, Rabin RL, Yannelli JR, Koniaris LG, Vanguri P, Farber JM. Human Mig chemokine: biochemical and functional characterization. J Exp Med. 1995 Nov 1;182(5):1301-14.

[7] Lee HH, Farber JM. Localization of the gene for the human MIG cytokine on chromosome 4q21 adjacent to INP10 reveals a chemokine "mini-cluster". Cytogenet Cell Genet. 1996;74(4):255-8.

[8] Loetscher M, Gerber B, Loetscher P, Jones SA, Piali L, Clark-Lewis I, Baggiolini M, Moser B. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. J Exp Med. 1996 Sep 1;184(3):963-9.

[9] Weng Y, Siciliano SJ, Waldburger KE, Sirotina-Meisher A, Staruch MJ, Daugherty BL, Gould SL, Springer MS, DeMartino JA. Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors. J Biol Chem. 1998 Jul 17;273(29):18288-91.

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