HLA-C

HLA-C
已知的结构
PDB	人类UniProt搜索：PDBe RCSB
PDBID列表
	3BZF,%%s4NT6,%%s1EFX,%%s1IM9、1QQD
标识符
代号	HLA-C
扩展标识	OMIM：142840；HomoloGene：133080；GeneCards：HLA-C；OMA：HLA-C - orthologs
基因位置（人类）
染色体	6號染色體
终止	31,272,130 bp
RNA表达模式
	Top expressed in
	right lung; ; right uterine tube; ; upper lobe of left lung;
	无数据
	查阅更多表达数据
	查阅更多表达数据
基因本體
分子功能	peptide antigen binding; 血浆蛋白结合;
細胞組分	integral component of membrane; phagocytic vesicle membrane; 高尔基体; early endosome membrane; 膜; Golgi membrane; 细胞膜; cell surface; 内质网; MHC class I protein complex; ER to Golgi transport vesicle membrane; integral component of lumenal side of endoplasmic reticulum membrane; 外排體; secretory granule membrane; recycling endosome membrane;
生物學過程	antigen processing and presentation; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; immune system process; interferon-gamma-mediated signaling pathway; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; type I interferon signaling pathway; 免疫反应; regulation of immune response; viral process; neutrophil degranulation;
	来源：Amigo / QuickGO
直系同源
	3107
	无数据
ENSG00000204525; ENSG00000233841; ENSG00000228299; ENSG00000225691; ENSG00000206435;
	ENSG00000237022; ENSG00000206452
	无数据
	P10321
	无数据
	NM_002117; NM_001243042
	无数据
	NP_001229971; NP_002108
	无数据
	维基数据
檢視/編輯人類

HLA-C是人類白細胞抗原（HLA）的一个基因座，位于6号染色体上。成熟的HLA-C蛋白会与β2微球蛋白组成异二聚体，作为一个受体锚定在细胞表面。

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000204525、ENSG00000233841、ENSG00000228299、ENSG00000225691、ENSG00000206435、ENSG00000237022、ENSG00000206452 – Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

延伸阅读

Geyer M, Fackler OT, Peterlin BM. Structure--function relationships in HIV-1 Nef.. EMBO Rep. 2001, 2 (7): 580–5. PMC 1083955 . PMID 11463741. doi:10.1093/embo-reports/kve141.
Greenway AL, Holloway G, McPhee DA; et al. HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication.. J. Biosci. 2004, 28 (3): 323–35. PMID 12734410. doi:10.1007/BF02970151.
Bénichou S, Benmerah A. [The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway]. Med Sci (Paris). 2003, 19 (1): 100–6. PMID 12836198. doi:10.1051/medsci/2003191100.
Leavitt SA, SchOn A, Klein JC; et al. Interactions of HIV-1 proteins gp120 and Nef with cellular partners define a novel allosteric paradigm.. Curr. Protein Pept. Sci. 2004, 5 (1): 1–8. PMID 14965316. doi:10.2174/1389203043486955.
Tolstrup M, Ostergaard L, Laursen AL; et al. HIV/SIV escape from immune surveillance: focus on Nef.. Curr. HIV Res. 2004, 2 (2): 141–51. PMID 15078178. doi:10.2174/1570162043484924.
Joseph AM, Kumar M, Mitra D. Nef: "necessary and enforcing factor" in HIV infection.. Curr. HIV Res. 2005, 3 (1): 87–94. PMID 15638726. doi:10.2174/1570162052773013.
Anderson JL, Hope TJ. HIV accessory proteins and surviving the host cell.. Current HIV/AIDS reports. 2005, 1 (1): 47–53. PMID 16091223. doi:10.1007/s11904-004-0007-x.

外部链接

Molecular Anthropology Yahoo Group（页面存档备份，存于互联网档案馆）
HLA Allele and Haplotype Frequency Database（页面存档备份，存于互联网档案馆）

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000204525、ENSG00000233841、ENSG00000228299、ENSG00000225691、ENSG00000206435、ENSG00000237022、ENSG00000206452 – Ensembl, May 2017

[2] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

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