LAMA1

LAMA1
已知的结构
PDB	直系同源搜索：PDBe RCSB
PDBID列表
	2JD4
标识符
代号	LAMA1
扩展标识	OMIM：150320；MGI：99892；HomoloGene：21146；GeneCards：LAMA1；OMA：LAMA1 - orthologs
基因位置（人类）
染色体	18號染色體
终止	7,117,797 bp
基因位置（小鼠）
染色体	小鼠17号染色体
终止	68,129,642 bp
RNA表达模式
	Top expressed in
	ventricular zone; ; right testis; ; left testis; ; mucosa of ileum; ; stromal cell of endometrium; ; ganglionic eminence; ; mucosa of colon; ; mucosa of sigmoid colon;
	Top expressed in
	tail of embryo; ; epithelium of lens; ; cumulus cell; ; inner renal medulla; ; cortical collecting duct;
	查阅更多表达数据
	; ;
	查阅更多表达数据
基因本體
分子功能	signaling receptor binding; extracellular matrix structural constituent; 血浆蛋白结合; protein C-terminus binding; glycosphingolipid binding;
細胞組分	细胞外间质; 細胞外區域; 基底膜; laminin-1 complex; laminin-3 complex; 細胞外空間; 膜; cell-cell junction; laminin complex; collagen-containing extracellular matrix;
生物學過程	cell surface receptor signaling pathway; regulation of cell adhesion; 細胞粘附; extracellular matrix organization; regulation of cell migration; regulation of embryonic development; morphogenesis of an epithelial sheet; protein phosphorylation; 组织发生; neuron projection development; establishment of epithelial cell apical/basal polarity; retina development in camera-type eye; epithelial tube branching involved in lung morphogenesis; branching involved in salivary gland morphogenesis; retinal blood vessel morphogenesis; 轴突导向; animal organ morphogenesis; camera-type eye development; blood vessel morphogenesis;
	来源：Amigo / QuickGO
直系同源
	284217
	16772
	ENSG00000101680
	ENSMUSG00000032796
	P25391
	P19137
	NM_005559
	NM_008480
	NP_005550
	NP_032506
	维基数据
檢視/編輯人類	檢視/編輯小鼠

层粘连蛋白亚基α1是一个层粘连蛋白的蛋白亚基。化学式为：C₁₄₉₆₀H₂₃₄₇₆O₄₈₉₇N₄₁₉₆S₂₀₃^[5]，层粘蛋白是一种组成核纤层的蛋白，在细胞核的形态维持中扮演重要角色。此蛋白質在人体内由LAMA1基因编码^[6]^[7]。

相互作用

层粘蛋白亚基α1会与FBLN2（英语：FBLN2）发生蛋白质相互作用^[8]^[9]。

参考资料

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000101680 – Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000032796 – Ensembl, 2017年5月
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ 层粘连蛋白亚基 α-1 | Expasy - ProtParam |注：分子式计算包含了UniProt上注释的63个二硫键修饰(未计算链间二硫键，因为是单体)，和5个N-連接的（GlcNAc…）天冬醯胺(糖鏈結構考慮為常見的双天线複雜型糖鏈GlcNAc₄Man₃Gal₂Fuc₁Neu5Ac₂淨增長C₉₀H₁₄₆N₆O₆₅，真实的糖链结构并非完全均一，但在已解析的层粘连蛋白结构中，双天线复杂型是主导形式，尤其在 LN 域等关键功能区域，所以均按照复杂型双天线计算. web.expasy.org. [2026-03-24].
^ Nagayoshi, T.; Mattei, M. G.; Passage, E.; Knowlton, R.; Chu, M. L.; Uitto, J. Human laminin A chain (LAMA) gene: chromosomal mapping to locus 18p11.3. Genomics. 1989-11, 5 (4): 932–935 [2021-11-10]. ISSN 0888-7543. PMID 2591971. doi:10.1016/0888-7543(89)90136-5. （原始内容存档于2021-11-10）.
^ LAMA1 laminin subunit alpha 1 [Homo sapiens (human)] - Gene - NCBI. www.ncbi.nlm.nih.gov. [2021-11-10]. （原始内容存档于2021-11-10）.
^ Utani, A.; Nomizu, M.; Yamada, Y. Fibulin-2 binds to the short arms of laminin-5 and laminin-1 via conserved amino acid sequences. The Journal of Biological Chemistry. 1997-01-31, 272 (5): 2814–2820 [2021-11-10]. ISSN 0021-9258. PMID 9006922. doi:10.1074/jbc.272.5.2814. （原始内容存档于2021-11-10）.
^ Talts, J. F.; Sasaki, T.; Miosge, N.; Göhring, W.; Mann, K.; Mayne, R.; Timpl, R. Structural and functional analysis of the recombinant G domain of the laminin alpha4 chain and its proteolytic processing in tissues. The Journal of Biological Chemistry. 2000-11-10, 275 (45): 35192–35199 [2021-11-10]. ISSN 0021-9258. PMID 10934193. doi:10.1074/jbc.M003261200. （原始内容存档于2022-01-21）.

拓展阅读

Haaparanta, T.; Uitto, J.; Ruoslahti, E.; Engvall, E. Molecular cloning of the cDNA encoding human laminin A chain. Matrix (Stuttgart, Germany). 1991-06, 11 (3): 151–160 [2021-11-10]. ISSN 0934-8832. PMID 1714537. doi:10.1016/s0934-8832(11)80153-8. （原始内容存档于2021-11-10）.
Nissinen, M; Vuolteenaho, R; Boot-Handford, R; Kallunki, P; Tryggvason, K. Primary structure of the human laminin A chain. Limited expression in human tissues. Biochemical Journal. 1991-06-01, 276 (2): 369–379 [2021-11-10]. ISSN 0264-6021. PMC 1151101 . PMID 2049067. doi:10.1042/bj2760369. （原始内容存档于2021-08-12）（英语）.
Taraboletti, G.; Rao, C. N.; Krutzsch, H. C.; Liotta, L. A.; Roberts, D. D. Sulfatide-binding domain of the laminin A chain. The Journal of Biological Chemistry. 1990-07-25, 265 (21): 12253–12258 [2021-11-10]. ISSN 0021-9258. PMID 2373692. （原始内容存档于2021-11-10）.
Olsen, D.; Nagayoshi, T.; Fazio, M.; Peltonen, J.; Jaakkola, S.; Sanborn, D.; Sasaki, T.; Kuivaniemi, H.; Chu, M. L. Human laminin: cloning and sequence analysis of cDNAs encoding A, B1 and B2 chains, and expression of the corresponding genes in human skin and cultured cells. Laboratory Investigation; a Journal of Technical Methods and Pathology. 1989-06, 60 (6): 772–782 [2021-11-10]. ISSN 0023-6837. PMID 2733383. （原始内容存档于2021-11-10）.
Leivo, I; Engvall, E. C3d fragment of complement interacts with laminin and binds to basement membranes of glomerulus and trophoblast.. The Journal of Cell Biology. 1986-09-01, 103 (3): 1091–1100 [2021-11-10]. ISSN 0021-9525. PMC 2114300 . PMID 3488995. doi:10.1083/jcb.103.3.1091. （原始内容存档于2022-01-21）（英语）.
Wewer, U. M.; Gerecke, D. R.; Durkin, M. E.; Kurtz, K. S.; Mattei, M. G.; Champliaud, M. F.; Burgeson, R. E.; Albrechtsen, R. Human beta 2 chain of laminin (formerly S chain): cDNA cloning, chromosomal localization, and expression in carcinomas. Genomics. 1994-11-15, 24 (2): 243–252 [2021-11-10]. ISSN 0888-7543. PMID 7698745. doi:10.1006/geno.1994.1612. （原始内容存档于2021-11-10）.
Yamada, H.; Shimizu, T.; Tanaka, T.; Campbell, K. P.; Matsumura, K. Dystroglycan is a binding protein of laminin and merosin in peripheral nerve. FEBS letters. 1994-09-19, 352 (1): 49–53 [2021-11-10]. ISSN 0014-5793. PMID 7925941. doi:10.1016/0014-5793(94)00917-1. （原始内容存档于2022-03-13）.
Moser, T. L.; Enghild, J. J.; Pizzo, S. V.; Stack, M. S. The extracellular matrix proteins laminin and fibronectin contain binding domains for human plasminogen and tissue plasminogen activator. The Journal of Biological Chemistry. 1993-09-05, 268 (25): 18917–18923 [2021-11-10]. ISSN 0021-9258. PMID 8360181. （原始内容存档于2021-11-10）. 、
Yurchenco, P. D.; Sung, U.; Ward, M. D.; Yamada, Y.; O'Rear, J. J. Recombinant laminin G domain mediates myoblast adhesion and heparin binding. The Journal of Biological Chemistry. 1993-04-15, 268 (11): 8356–8365 [2021-11-10]. ISSN 0021-9258. PMID 8463343. （原始内容存档于2021-11-10）.
Ancsin, J. B.; Kisilevsky, R. Characterization of high affinity binding between laminin and the acute-phase protein, serum amyloid A. The Journal of Biological Chemistry. 1997-01-03, 272 (1): 406–413 [2021-11-10]. ISSN 0021-9258. PMID 8995276. doi:10.1074/jbc.272.1.406. （原始内容存档于2021-11-10）.
Zahedi, K. Characterization of the binding of serum amyloid P to laminin. The Journal of Biological Chemistry. 1997-01-24, 272 (4): 2143–2148 [2021-11-10]. ISSN 0021-9258. PMID 8999915. （原始内容存档于2021-11-10）.
Utani, A.; Nomizu, M.; Yamada, Y. Fibulin-2 binds to the short arms of laminin-5 and laminin-1 via conserved amino acid sequences. The Journal of Biological Chemistry. 1997-01-31, 272 (5): 2814–2820 [2021-11-10]. ISSN 0021-9258. PMID 9006922. doi:10.1074/jbc.272.5.2814. （原始内容存档于2021-11-10）.
Cáceres, J.; Brandan, E. Interaction between Alzheimer's disease beta A4 precursor protein (APP) and the extracellular matrix: evidence for the participation of heparan sulfate proteoglycans. Journal of Cellular Biochemistry. 1997-05, 65 (2): 145–158 [2021-11-10]. ISSN 0730-2312. PMID 9136074. doi:10.1002/(sici)1097-4644(199705)65:2<145::aid-jcb2>3.0.co;2-u. （原始内容存档于2021-11-10）.
Chen, M.; Marinkovich, M. P.; Veis, A.; Cai, X.; Rao, C. N.; O'Toole, E. A.; Woodley, D. T. Interactions of the amino-terminal noncollagenous (NC1) domain of type VII collagen with extracellular matrix components. A potential role in epidermal-dermal adherence in human skin. The Journal of Biological Chemistry. 1997-06-06, 272 (23): 14516–14522 [2021-11-10]. ISSN 0021-9258. PMID 9169408. doi:10.1074/jbc.272.23.14516. （原始内容存档于2022-04-06）.
Schuger, L.; Skubitz, A. P.; Zhang, J.; Sorokin, L.; He, L. Laminin alpha1 chain synthesis in the mouse developing lung: requirement for epithelial-mesenchymal contact and possible role in bronchial smooth muscle development. The Journal of Cell Biology. 1997-10-20, 139 (2): 553–562 [2021-11-10]. ISSN 0021-9525. PMC 2139794 . PMID 9334356. doi:10.1083/jcb.139.2.553. （原始内容存档于2021-11-10）.
Mrowiec, T.; Melchar, C.; Górski, A. HIV-protein-mediated alterations in T cell interactions with the extracellular matrix proteins and endothelium. Archivum Immunologiae Et Therapiae Experimentalis. 1997, 45 (2-3): 255–259 [2021-11-10]. ISSN 0004-069X. PMID 9597096. （原始内容存档于2021-11-10）.
O'Grady, P.; Thai, T. C.; Saito, H. The laminin-nidogen complex is a ligand for a specific splice isoform of the transmembrane protein tyrosine phosphatase LAR. The Journal of Cell Biology. 1998-06-29, 141 (7): 1675–1684 [2021-11-10]. ISSN 0021-9525. PMC 2133008 . PMID 9647658. doi:10.1083/jcb.141.7.1675. （原始内容存档于2021-11-10）.
Ettner, N.; Göhring, W.; Sasaki, T.; Mann, K.; Timpl, R. The N-terminal globular domain of the laminin alpha1 chain binds to alpha1beta1 and alpha2beta1 integrins and to the heparan sulfate-containing domains of perlecan. FEBS letters. 1998-07-03, 430 (3): 217–221 [2021-11-10]. ISSN 0014-5793. PMID 9688542. doi:10.1016/s0014-5793(98)00601-2. （原始内容存档于2021-11-10）.
Ludwig, H. C.; Rausch, S.; Schallock, K.; Markakis, E. Expression of CD 73 (ecto-5'-nucleotidase) in 165 glioblastomas by immunohistochemistry and electronmicroscopic histochemistry. Anticancer Research. 1999-05, 19 (3A): 1747–1752 [2021-11-10]. ISSN 0250-7005. PMID 10470109. （原始内容存档于2021-11-10）.

这是一篇與生物化學相關的小作品。您可以通过编辑或修订扩充其内容。

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000101680 – Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000032796 – Ensembl, 2017年5月

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] 层粘连蛋白亚基 α-1 | Expasy - ProtParam |注：分子式计算包含了UniProt上注释的63个二硫键修饰(未计算链间二硫键，因为是单体)，和5个N-連接的（GlcNAc…）天冬醯胺(糖鏈結構考慮為常見的双天线複雜型糖鏈GlcNAc₄Man₃Gal₂Fuc₁Neu5Ac₂淨增長C₉₀H₁₄₆N₆O₆₅，真实的糖链结构并非完全均一，但在已解析的层粘连蛋白结构中，双天线复杂型是主导形式，尤其在 LN 域等关键功能区域，所以均按照复杂型双天线计算. web.expasy.org. [2026-03-24].

[pmid2591971-6] Nagayoshi, T.; Mattei, M. G.; Passage, E.; Knowlton, R.; Chu, M. L.; Uitto, J. Human laminin A chain (LAMA) gene: chromosomal mapping to locus 18p11.3. Genomics. 1989-11, 5 (4): 932–935 [2021-11-10]. ISSN 0888-7543. PMID 2591971. doi:10.1016/0888-7543(89)90136-5. （原始内容存档于2021-11-10）.

[entrez-7] LAMA1 laminin subunit alpha 1 [Homo sapiens (human)] - Gene - NCBI. www.ncbi.nlm.nih.gov. [2021-11-10]. （原始内容存档于2021-11-10）.

[pmid9006922-8] Utani, A.; Nomizu, M.; Yamada, Y. Fibulin-2 binds to the short arms of laminin-5 and laminin-1 via conserved amino acid sequences. The Journal of Biological Chemistry. 1997-01-31, 272 (5): 2814–2820 [2021-11-10]. ISSN 0021-9258. PMID 9006922. doi:10.1074/jbc.272.5.2814. （原始内容存档于2021-11-10）.

[pmid10934193-9] Talts, J. F.; Sasaki, T.; Miosge, N.; Göhring, W.; Mann, K.; Mayne, R.; Timpl, R. Structural and functional analysis of the recombinant G domain of the laminin alpha4 chain and its proteolytic processing in tissues. The Journal of Biological Chemistry. 2000-11-10, 275 (45): 35192–35199 [2021-11-10]. ISSN 0021-9258. PMID 10934193. doi:10.1074/jbc.M003261200. （原始内容存档于2022-01-21）.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]