PF-592,379

PF-592,379
臨床資料
给药途径	Oral
法律規範狀態
法律規範	Investigational (discontinued);
识别信息
	IUPAC命名法 5-[(2R,5S)-5-methyl-4-propylmorpholin-2-yl]pyridin-2-amine; ;
CAS号	710655-15-5
PubChem CID	10263487;
IUPHAR/BPS	7683;
ChemSpider	8438966;
UNII	66B7UY5K7I;
CompTox Dashboard (EPA)	DTXSID901030407 ;
化学信息
化学式	C13H21N3O
摩尔质量	235.33 g·mol−1
3D模型（JSmol）	交互式图像;
	SMILES CCCN([C@@H](C)CO1)C[C@H]1C2=CN=C(N)C=C2;
	InChI InChI=1S/C13H21N3O/c1-3-6-16-8-12(17-9-10(16)2)11-4-5-13(14)15-7-11/h4-5,7,10,12H,3,6,8-9H2,1-2H3,(H2,14,15)/t10-,12-/m0/s1; Key:DFTCYTDJDXZFSK-JQWIXIFHSA-N;

PF-592,379是一种含氮有机化合物，化学式C
13H
21N
3O，属于一种多巴胺受体D₃选择性激动剂^[1]，由輝瑞制药研发^[2]。

参考文献

^ Attkins N, Betts A, Hepworth D, Heatherington AC. Pharmacokinetics and elucidation of the rates and routes of N-glucuronidation of PF-592379, an oral dopamine 3 agonist in rat, dog, and human. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. November 2010, 40 (11): 730–42. PMID 20836725. S2CID 30288414. doi:10.3109/00498254.2010.514961.
^ Collins GT, Butler P, Wayman C, Ratcliffe S, Gupta P, Oberhofer G, Caine SB. Lack of abuse potential in a highly selective dopamine D3 agonist, PF-592,379, in drug self-administration and drug discrimination in rats. Behavioural Pharmacology. June 2012, 23 (3): 280–91. PMC 3365486 . PMID 22470105. doi:10.1097/FBP.0b013e3283536d21.