Spo11

Spo11
标识符
代号	SPO11
扩展标识	OMIM：605114；MGI：1349669；HomoloGene：6059；GeneCards：SPO11；OMA：SPO11 - orthologs
基因位置（人类）
染色体	20號染色體
终止	57,343,994 bp
基因位置（小鼠）
染色体	小鼠2号染色体
终止	172,835,369 bp
RNA表达模式
	Top expressed in
	right testis; ; left testis; ; mononuclear cell;
	Top expressed in
	tail of embryo;
	查阅更多表达数据
	无数据
基因本體
分子功能	金屬離子結合; 催化活性; 水解酶活性; ATP結合; 血浆蛋白结合; isomerase activity; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; endodeoxyribonuclease activity, producing 3'-phosphomonoesters; DNA结合;
細胞組分	染色体; 端粒; 细胞核; nuclear chromosome;
生物學過程	protein localization to chromosome; 雌配子发生; meiotic telomere clustering; male meiosis I; DNA代谢过程; DNA catabolic process, endonucleolytic; 卵子发生; homologous chromosome pairing at meiosis; 減數分裂; synaptonemal complex assembly; 精子发生; spermatid development; ovarian follicle development; meiotic DNA double-strand break processing; meiotic DNA double-strand break formation; reciprocal meiotic recombination; double-strand break repair involved in meiotic recombination;
	来源：Amigo / QuickGO
直系同源
	23626
	26972
	ENSG00000054796
	ENSMUSG00000005883
	Q9Y5K1; Q5TCH6
	Q9WTK8
	NM_012444; NM_198265
	NM_001083959; NM_001083960; NM_012046; NM_001305434
	NP_036576; NP_937998
	NP_001077428; NP_001077429; NP_001292363; NP_036176
	维基数据
檢視/編輯人類	檢視/編輯小鼠

Spo11是人类基因spo11 编码的蛋白质，在真核生物中广泛存在，与古菌基因TopVIA为直系同源体，负责减数第一次分裂前期遺傳重組中DNA的双链断裂的形成^[5]^[6]。

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000054796 – Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000005883 – Ensembl, 2017年5月
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Vrielynck N, Chambon A, Vezon D, Pereira L, Chelysheva L, De Muyt A, et al. A DNA topoisomerase VI-like complex initiates meiotic recombination. Science. February 2016, 351 (6276): 939–43 [2020-08-29]. Bibcode:2016Sci...351..939V. PMID 26917763. S2CID 206643600. doi:10.1126/science.aad5196. （原始内容存档于2020-07-11）.
^ Robert T, Nore A, Brun C, Maffre C, Crimi B, Bourbon HM, de Massy B. The TopoVIB-Like protein family is required for meiotic DNA double-strand break formation. Science. February 2016, 351 (6276): 943–9 [2020-08-29]. Bibcode:2016Sci...351..943R. PMID 26917764. S2CID 9445593. doi:10.1126/science.aad5309. （原始内容存档于2020-07-11）.

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000054796 – Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000005883 – Ensembl, 2017年5月

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Vrielynck N, Chambon A, Vezon D, Pereira L, Chelysheva L, De Muyt A, et al. A DNA topoisomerase VI-like complex initiates meiotic recombination. Science. February 2016, 351 (6276): 939–43 [2020-08-29]. Bibcode:2016Sci...351..939V. PMID 26917763. S2CID 206643600. doi:10.1126/science.aad5196. （原始内容存档于2020-07-11）.

[6] Robert T, Nore A, Brun C, Maffre C, Crimi B, Bourbon HM, de Massy B. The TopoVIB-Like protein family is required for meiotic DNA double-strand break formation. Science. February 2016, 351 (6276): 943–9 [2020-08-29]. Bibcode:2016Sci...351..943R. PMID 26917764. S2CID 9445593. doi:10.1126/science.aad5309. （原始内容存档于2020-07-11）.

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