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TAX1BP1

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TAX1BP1
已知的结构
PDB直系同源搜索:PDBe RCSB
标识符
代号TAX1BP1
扩展标识OMIM605326MGI1289308HomoloGene4395GeneCardsTAX1BP1OMATAX1BP1 - orthologs
直系同源
物種人類小鼠
Entrez
8887
52440
Ensembl
ENSG00000106052
ENSMUSG00000004535
UniProt
Q86VP1
Q3UKC1
mRNA序列
NM_025816
​NM_001355595
​NM_001355596
蛋白序列
NP_080092
​NP_001342524
​NP_001342525
基因位置Chr 7:27.74 – 27.84 MbChr 6:52.69 – 52.74 Mb
PubMed查询[3][4]
维基数据
檢視/編輯人類檢視/編輯小鼠

TAX1BP1Tax1 binding protein 1,“Tax1结合蛋白1”)也称为CALCOCO3Calcium-binding and coiled-coil domain-containing protein 3,“钙结合和卷曲螺旋区蛋白3”)是人类基因 TAX1BP1 编码的蛋白质[5],其名称来源于能和人類嗜T淋巴球病毒一型(HTLV-1)的蛋白Tax1结合[5]

蛋白质的相互作用

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TAX1BP1蛋白与下列蛋白質进行互作A20[6]TRAF6[7],在与A20或TRAF6结合后抑制NF-κB转录因子激活。

参考文献

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  1. ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000106052Ensembl, May 2017
  2. ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000004535Ensembl, 2017年5月
  3. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ 5.0 5.1 Entrez Gene: TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1. 
  6. ^ De Valck D, Jin DY, Heyninck K, Van de Craen M, Contreras R, Fiers W, Jeang KT, Beyaert R. The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases. Oncogene. July 1999, 18 (29): 4182–90. PMID 10435631. doi:10.1038/sj.onc.1202787可免费查阅. 
  7. ^ Ling L, Goeddel DV. T6BP, a TRAF6-interacting protein involved in IL-1 signaling. Proceedings of the National Academy of Sciences of the United States of America. August 2000, 97 (17): 9567–72. Bibcode:2000PNAS...97.9567L. PMC 16905可免费查阅. PMID 10920205. doi:10.1073/pnas.170279097可免费查阅.