TIGIT [ 5] (又叫含IgG和ITIM结构域T细胞免疫受体)。是存在于一些T细胞 和自然杀伤细胞 (NK)的免疫受体。[ 6] 它又被称作是WUCAM[ 7] 和Vstm3[ 8] 。TIGIT可以高亲和力结合樹突狀細胞 (DCs)和巨噬细胞 等上的CD155(PVR),低亲和力结合CD112 (PVRL2)。
^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000181847 – Ensembl , May 2017
^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000071552 – Ensembl , 2017年5月
^ Human PubMed Reference: . National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference: . National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lung Cancer and Immunotherapy with Dr. Patrick Forde and Oswald Peterson . YouTube. October 22, 2021 [5 July 2022] .
^ Yu X, Harden K, Gonzalez LC, Francesco M, Chiang E, Irving B, Tom I, Ivelja S, Refino CJ, Clark H, Eaton D, Grogan JL. The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. Nat Immunol. Jan 2009, 10 (1): 48–57. PMID 19011627 . S2CID 205361984 . doi:10.1038/ni.1674 .
^ Boles KS, Vermi W, Facchetti F, Fuchs A, Wilson TJ, Diacovo TG, Cella M, Colonna M. A novel molecular interaction for the adhesion of follicular CD4 T cells to follicular DC . European Journal of Immunology. Mar 2009, 39 (3): 695–703. PMC 3544471 . PMID 19197944 . doi:10.1002/eji.200839116 .
^ Levin SD, Taft DW, Brandt CS, Bucher C, Howard ED, Chadwick EM, et al. Vstm3 is a member of the CD28 family and an important modulator of T-cell function . European Journal of Immunology. April 2011, 41 (4): 902–15. PMC 3733993 . PMID 21416464 . doi:10.1002/eji.201041136 .