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TIGIT

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维基百科,自由的百科全书
TIGIT
已知的结构
PDB直系同源搜索:PDBe RCSB
标识符
代号TIGIT
扩展标识OMIM612859MGI3642260HomoloGene18358GeneCardsTIGITOMATIGIT - orthologs
直系同源
物種人類小鼠
Entrez
201633
100043314
Ensembl
ENSG00000181847
ENSMUSG00000071552
UniProt
Q495A1
P86176,A0A0B4J1G6
mRNA序列
NM_173799
NM_001146325
蛋白序列
NP_776160
NP_001139797
基因位置Chr 3:114.28 – 114.31 MbChr 16:43.47 – 43.48 Mb
PubMed查询[3][4]
维基数据
檢視/編輯人類檢視/編輯小鼠

TIGIT[5](又叫含IgG和ITIM结构域T细胞免疫受体)。是存在于一些T细胞自然杀伤细胞(NK)的免疫受体。[6]它又被称作是WUCAM[7]和Vstm3[8]。TIGIT可以高亲和力结合樹突狀細胞(DCs)和巨噬细胞等上的CD155(PVR),低亲和力结合CD112 (PVRL2)。

参考

[编辑]
  1. ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000181847Ensembl, May 2017
  2. ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000071552Ensembl, 2017年5月
  3. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ Lung Cancer and Immunotherapy with Dr. Patrick Forde and Oswald Peterson. YouTube. October 22, 2021 [5 July 2022]. 
  6. ^ Yu X, Harden K, Gonzalez LC, Francesco M, Chiang E, Irving B, Tom I, Ivelja S, Refino CJ, Clark H, Eaton D, Grogan JL. The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. Nat Immunol. Jan 2009, 10 (1): 48–57. PMID 19011627. S2CID 205361984. doi:10.1038/ni.1674. 
  7. ^ Boles KS, Vermi W, Facchetti F, Fuchs A, Wilson TJ, Diacovo TG, Cella M, Colonna M. A novel molecular interaction for the adhesion of follicular CD4 T cells to follicular DC. European Journal of Immunology. Mar 2009, 39 (3): 695–703. PMC 3544471可免费查阅. PMID 19197944. doi:10.1002/eji.200839116. 
  8. ^ Levin SD, Taft DW, Brandt CS, Bucher C, Howard ED, Chadwick EM, et al. Vstm3 is a member of the CD28 family and an important modulator of T-cell function. European Journal of Immunology. April 2011, 41 (4): 902–15. PMC 3733993可免费查阅. PMID 21416464. doi:10.1002/eji.201041136.