TRAF5 （“TNF受体相关因子5”，TNF receptor associated factor 5 RING finger protein 84 基因 TRAF5 编码的蛋白质 ，属于一种TNF受体相关因子 （TRAF）。
TRAF5蛋白与下列蛋白質进行互作 ：
^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000082512 – Ensembl , May 2017^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000026637 – Ensembl , 2017年5月^ Human PubMed Reference: . National Center for Biotechnology Information, U.S. National Library of Medicine. ^ Mouse PubMed Reference: . National Center for Biotechnology Information, U.S. National Library of Medicine. ^ Nishitoh H, Saitoh M, Mochida Y, Takeda K, Nakano H, Rothe M, Miyazono K, Ichijo H. ASK1 is essential for JNK/SAPK activation by TRAF2. Molecular Cell. Sep 1998, 2 (3): 389–95. PMID 9774977 doi:10.1016/s1097-2765(00)80283-x ^ Hoeflich KP, Yeh WC, Yao Z, Mak TW, Woodgett JR. Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1). Oncogene. Oct 1999, 18 (42): 5814–20. PMID 10523862 S2CID 12132452 doi:10.1038/sj.onc.1202975 ^ Kawamata S, Hori T, Imura A, Takaori-Kondo A, Uchiyama T. Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation . The Journal of Biological Chemistry. Mar 1998, 273 (10): 5808–14. PMID 9488716 doi:10.1074/jbc.273.10.5808 ^ Aizawa S, Nakano H, Ishida T, Horie R, Nagai M, Ito K, Yagita H, Okumura K, Inoue J, Watanabe T. Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation . The Journal of Biological Chemistry. Jan 1997, 272 (4): 2042–5. PMID 8999898 doi:10.1074/jbc.272.4.2042 ^ Tsukamoto N, Kobayashi N, Azuma S, Yamamoto T, Inoue J. Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40 . Proceedings of the National Academy of Sciences of the United States of America. Feb 1999, 96 (4): 1234–9. Bibcode:1999PNAS...96.1234T PMC 15446 PMID 9990007 doi:10.1073/pnas.96.4.1234 ^ Ishida TK, Tojo T, Aoki T, Kobayashi N, Ohishi T, Watanabe T, Yamamoto T, Inoue J. TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling . Proceedings of the National Academy of Sciences of the United States of America. Sep 1996, 93 (18): 9437–42. Bibcode:1996PNAS...93.9437I PMC 38446 PMID 8790348 doi:10.1073/pnas.93.18.9437 ^ Darnay BG, Haridas V, Ni J, Moore PA, Aggarwal BB. Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase . The Journal of Biological Chemistry. Aug 1998, 273 (32): 20551–5. PMID 9685412 doi:10.1074/jbc.273.32.20551 ^ Darnay BG, Ni J, Moore PA, Aggarwal BB. Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif . The Journal of Biological Chemistry. Mar 1999, 274 (12): 7724–31. PMID 10075662 doi:10.1074/jbc.274.12.7724 ^ Galibert L, Tometsko ME, Anderson DM, Cosman D, Dougall WC. The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily . The Journal of Biological Chemistry. Dec 1998, 273 (51): 34120–7. PMID 9852070 doi:10.1074/jbc.273.51.34120 ^ Xia XZ, Treanor J, Senaldi G, Khare SD, Boone T, Kelley M, Theill LE, Colombero A, Solovyev I, Lee F, McCabe S, Elliott R, Miner K, Hawkins N, Guo J, Stolina M, Yu G, Wang J, Delaney J, Meng SY, Boyle WJ, Hsu H. TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation . The Journal of Experimental Medicine. Jul 2000, 192 (1): 137–43. PMC 1887716 PMID 10880535 doi:10.1084/jem.192.1.137 ^ Hsu H, Solovyev I, Colombero A, Elliott R, Kelley M, Boyle WJ. ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5 . The Journal of Biological Chemistry. May 1997, 272 (21): 13471–4. PMID 9153189 doi:10.1074/jbc.272.21.13471 ^ Marsters SA, Ayres TM, Skubatch M, Gray CL, Rothe M, Ashkenazi A. Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1 . The Journal of Biological Chemistry. May 1997, 272 (22): 14029–32. PMID 9162022 doi:10.1074/jbc.272.22.14029
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