UCP2

UCP2
标识符
代号	UCP2
扩展标识	OMIM：601693；MGI：109354；HomoloGene：2516；GeneCards：UCP2；OMA：UCP2 - orthologs
基因位置（人类）
染色体	11號染色體
终止	73,983,246 bp
基因位置（小鼠）
染色体	小鼠7号染色体
终止	100,151,227 bp
RNA表达模式
	Top expressed in
	bronchial epithelial cell; ; right uterine tube; ; epithelium of nasopharynx; ; nasal epithelium; ; palpebral conjunctiva;
	Top expressed in
	epithelium of stomach; ; pyloric antrum; ; fetal liver hematopoietic progenitor cell; ; mucous cell of stomach; ; tibiofemoral joint;
	查阅更多表达数据
	; ;
	查阅更多表达数据
基因本體
分子功能	血浆蛋白结合; oxidative phosphorylation uncoupler activity; transmembrane transporter activity;
細胞組分	細胞質; 膜; mitochondrial membranes; mitochondrial inner membrane; integral component of membrane; 線粒體;
生物學過程	positive regulation of cell death; response to hypoxia; response to superoxide; response to fatty acid; female pregnancy; cellular response to amino acid starvation; negative regulation of insulin secretion involved in cellular response to glucose stimulus; 老化; negative regulation of apoptotic process; response to glucose; regulation of mitochondrial membrane potential; liver regeneration; cellular response to hormone stimulus; cellular response to insulin stimulus; cellular response to glucose stimulus; response to cold; mitochondrial transmembrane transport; adaptive thermogenesis; mitochondrial transport; proton transmembrane transport; positive regulation of cold-induced thermogenesis;
	来源：Amigo / QuickGO
直系同源
	7351
	22228
	ENSG00000175567
	ENSMUSG00000033685
	P55851
	P70406
	NM_003355
	NM_011671
NP_003346; NP_001368872; NP_001368873; NP_001368874; NP_001368876;
	NP_001368877; NP_001368878; NP_001368879
	NP_035801
	维基数据
檢視/編輯人類	檢視/編輯小鼠

线粒体解偶联蛋白2是一种在人类中由UCP2基因编码的蛋白。线粒体解偶联蛋白是线粒体阴离子载体蛋白大家族的成员。UCP通过将线粒体膜电位耗散为热量（也称为线粒体质子泄漏），从而将氧化磷酸化与ATP合成分离或分离。UCP促进阴离子从线粒体内膜转移到线粒体外膜，并促进质子从线粒体外膜返回到线粒体内膜。

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000175567 – Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000033685 – Ensembl, 2017年5月
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000175567 – Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000033685 – Ensembl, 2017年5月

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

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