VAC14

VAC14
标识符
代号	VAC14
扩展标识	OMIM：604632；MGI：2157980；HomoloGene：6528；GeneCards：VAC14；OMA：VAC14 - orthologs
基因位置（人类）
染色体	16號染色體
终止	70,801,160 bp
基因位置（小鼠）
染色体	小鼠8号染色体
终止	111,447,030 bp
RNA表达模式
	Top expressed in
	stromal cell of endometrium; ; muscle of thigh; ; mucosa of transverse colon; ; apex of heart; ; right lobe of liver; ; right frontal lobe; ; right lobe of thyroid gland;
	Top expressed in
	tail of embryo; ; right kidney; ; muscle of thigh;
	查阅更多表达数据
	无数据
基因本體
分子功能	血浆蛋白结合; signaling receptor activity;
細胞組分	organelle membrane; Golgi membrane; 核内体; early endosome membrane; endosome membrane; PAS complex; 内质网; late endosome membrane; 膜; 細胞內膜結合細胞器; extrinsic component of vacuolar membrane;
生物學過程	viral process; 訊息傳遞; phosphatidylinositol biosynthetic process;
	来源：Amigo / QuickGO
直系同源
	55697
	234729
	ENSG00000103043
	ENSMUSG00000010936
	Q08AM6
	Q80WQ2
	NM_018052; NM_001351157
	NM_146216
	NP_060522; NP_001338086
	NP_666328
	维基数据
檢視/編輯人類	檢視/編輯小鼠

VAC14也称为ArPIKfyve（Associated Regulator of PIKfyve，“PIKfyve相关调节因子”）或TAX1BP2（Tax1 binding protein 2，“Tax1结合蛋白2”）是人类基因 VAC14 编码的蛋白质^[5]^[6]^[7]。

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000103043 – Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000010936 – Ensembl, 2017年5月
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Entrez Gene: Vac14 homolog (S. cerevisiae).
^ Davy BE, Robinson ML. Congenital hydrocephalus in hy3 mice is caused by a frameshift mutation in Hydin, a large novel gene. Human Molecular Genetics. May 2003, 12 (10): 1163–1170. PMID 12719380. doi:10.1093/hmg/ddg122 .
^ Sbrissa D, Ikonomov OC, Strakova J, Dondapati R, Mlak K, Deeb R, et al. A mammalian ortholog of Saccharomyces cerevisiae Vac14 that associates with and up-regulates PIKfyve phosphoinositide 5-kinase activity. Molecular and Cellular Biology. December 2004, 24 (23): 10437–10447. PMC 529046 . PMID 15542851. doi:10.1128/MCB.24.23.10437-10447.2004.

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000103043 – Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000010936 – Ensembl, 2017年5月

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] Entrez Gene: Vac14 homolog (S. cerevisiae).

[pmid12719380-6] Davy BE, Robinson ML. Congenital hydrocephalus in hy3 mice is caused by a frameshift mutation in Hydin, a large novel gene. Human Molecular Genetics. May 2003, 12 (10): 1163–1170. PMID 12719380. doi:10.1093/hmg/ddg122 .

[pmid15542851-7] Sbrissa D, Ikonomov OC, Strakova J, Dondapati R, Mlak K, Deeb R, et al. A mammalian ortholog of Saccharomyces cerevisiae Vac14 that associates with and up-regulates PIKfyve phosphoinositide 5-kinase activity. Molecular and Cellular Biology. December 2004, 24 (23): 10437–10447. PMC 529046 . PMID 15542851. doi:10.1128/MCB.24.23.10437-10447.2004.

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