TAS2R40

TAS2R40
标识符
代号	TAS2R40
扩展标识	OMIM：613964；MGI：2681312；HomoloGene：47977；GeneCards：TAS2R40；OMA：TAS2R40 - orthologs
基因位置（人类）
染色体	7号染色体
终止	143,223,079 bp
基因位置（小鼠）
染色体	小鼠6号染色体
终止	42,193,221 bp
RNA表达模式
	Top expressed in
	right lung; ; left uterine tube; ; upper lobe of lung;
	无数据
	查阅更多表达数据
	无数据
基因本体
分子功能	G protein-coupled receptor activity; signal transducer activity; bitter taste receptor activity;
细胞组分	细胞膜; 膜; integral component of membrane;
生物学过程	detection of chemical stimulus involved in sensory perception of bitter taste; 讯息传递; response to stimulus; sensory perception of taste; G protein-coupled receptor signaling pathway;
	来源：Amigo / QuickGO
直系同源
	259286
	387515
	ENSG00000221937
	ENSMUSG00000051917
	P59535
	Q7TQB8
	NM_176882
	NM_001001453
	NP_795363
	NP_001001453
	维基数据
查看/编辑人类	查看/编辑小鼠

味觉感受器，类型2，成员40，TAS2R40是一个人类基因组中TAS2R40基因编码的蛋白质，是苦味味觉感受器的一员。^[5]^[6]

另见

味觉感受器

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000221937 – Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000051917 – Ensembl, 2017年5月
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W. The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. Nat Genet. Oct 2002, 32 (3): 397–401. PMID 12379855. doi:10.1038/ng1014.
^ Entrez Gene: TAS2R40 taste receptor, type 2, member 40.

延伸阅读

Margolskee RF. Molecular mechanisms of bitter and sweet taste transduction.. J. Biol. Chem. 2002, 277 (1): 1–4. PMID 11696554. doi:10.1074/jbc.R100054200.
Montmayeur JP, Matsunami H. Receptors for bitter and sweet taste.. Curr. Opin. Neurobiol. 2002, 12 (4): 366–71. PMID 12139982. doi:10.1016/S0959-4388(02)00345-8.
Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Zhang Y, Hoon MA, Chandrashekar J; et al. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.. Cell. 2003, 112 (3): 293–301. PMID 12581520. doi:10.1016/S0092-8674(03)00071-0.
Scherer SW, Cheung J, MacDonald JR; et al. Human chromosome 7: DNA sequence and biology.. Science. 2003, 300 (5620): 767–72. PMC 2882961 . PMID 12690205. doi:10.1126/science.1083423.
Gerhard DS, Wagner L, Feingold EA; et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Fischer A, Gilad Y, Man O, Pääbo S. Evolution of bitter taste receptors in humans and apes.. Mol. Biol. Evol. 2005, 22 (3): 432–6. PMID 15496549. doi:10.1093/molbev/msi027.
Go Y, Satta Y, Takenaka O, Takahata N. Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.. Genetics. 2006, 170 (1): 313–26. PMC 1449719 . PMID 15744053. doi:10.1534/genetics.104.037523.

TAS2R40引用了美国国家医学图书馆提供的资料，这些资料属于公共领域。

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000221937 – Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000051917 – Ensembl, 2017年5月

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12379855-5] Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W. The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. Nat Genet. Oct 2002, 32 (3): 397–401. PMID 12379855. doi:10.1038/ng1014.

[entrez-6] Entrez Gene: TAS2R40 taste receptor, type 2, member 40.

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