DEDD

DEDD
標識符
代號	DEDD
擴展標識	OMIM：606841；MGI：1333874；HomoloGene：7980；GeneCards：DEDD；OMA：DEDD - orthologs
基因位置（人類）
染色體	1號染色體
終止	161,132,688 bp
基因位置（小鼠）
染色體	小鼠1號染色體
終止	171,169,899 bp
RNA表達模式
	Top expressed in
	muscle of thigh;
	Top expressed in
	primary oocyte; ; neural layer of retina; ; muscle of thigh;
	查閱更多表達數據
	; ; ; ;
	查閱更多表達數據
基因本體
分子功能	血漿蛋白結合; DNA結合;
細胞組分	細胞質; 細胞核; 核仁;
生物學過程	regulation of apoptotic process; regulation of transcription, DNA-templated; transcription, DNA-templated; 細胞凋亡; 精子發生; extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of protein catabolic process; 蛻膜化; negative regulation of transcription of nucleolar large rRNA by RNA polymerase I;
	來源：Amigo / QuickGO
直系同源
	9191
	21945
	ENSG00000158796
	ENSMUSG00000013973
	O75618
	Q9Z1L3
	NM_001039711; NM_001039712; NM_004216; NM_032998; NM_001330765
NM_001128609; NM_011615; NM_001357550; NM_001357551; NM_001357552;
	NM_001357553
	NP_001034800; NP_001034801; NP_001317694; NP_127491
NP_001122081; NP_035745; NP_001344479; NP_001344480; NP_001344481;
	NP_001344482
	維基數據
檢視/編輯人類	檢視/編輯小鼠

含死亡效應結構域蛋白（英語：Death effector domain containing protein）是人類中由DEDD基因編碼的蛋白質。^[5]^[6]^[7]

功能

該基因編碼含有死亡效應結構域（DED）的蛋白質。DED是程序性細胞死亡途徑的銜接子、調節子和執行子共享的蛋白質相互作用域。該基因的過度表達被證明可誘導微弱的細胞凋亡。在刺激作用下，發現該蛋白從細胞質易位到細胞核，並與UBTF共定位在核仁中，UBTF是RNA聚合酶I轉錄所需的基礎因子。該基因至少有三種編碼相同蛋白質的轉錄變體。^[8]

相互作用

DEDD已被證明可以與以下基因產生相互作用：

參考資料

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000158796 – Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000013973 – Ensembl, 2017年5月
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^5.0 ^5.1 Stegh AH, Schickling O, Ehret A, Scaffidi C, Peterhänsel C, Hofmann TG, Grummt I, Krammer PH, Peter ME. DEDD, a novel death effector domain-containing protein, targeted to the nucleolus. EMBO J. Dec 1998, 17 (20): 5974–86. PMC 1170924 . PMID 9774341. doi:10.1093/emboj/17.20.5974.
^ Leo CP, Hsu SY, McGee EA, Salanova M, Hsueh AJ. DEFT, a novel death effector domain-containing molecule predominantly expressed in testicular germ cells. Endocrinology. Dec 1998, 139 (12): 4839–48. PMID 9832420. doi:10.1210/endo.139.12.6335 .
^ Entrez Gene: DEDD death effector domain containing. [2024-03-15]. （原始內容存檔於2010-12-05）.
^ 引用錯誤：沒有為名為entrez2的參考文獻提供內容
^ ^9.0 ^9.1 Zhan Y, Hegde R, Srinivasula SM, Fernandes-Alnemri T, Alnemri ES. Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC. Cell Death Differ. Apr 2002, 9 (4): 439–47. PMID 11965497. doi:10.1038/sj.cdd.4401038 .
^ ^10.0 ^10.1 Roth W, Stenner-Liewen F, Pawlowski K, Godzik A, Reed JC. Identification and characterization of DEDD2, a death effector domain-containing protein. J. Biol. Chem. Mar 2002, 277 (9): 7501–8. PMID 11741985. doi:10.1074/jbc.M110749200 .
^ Stegh AH, Schickling O, Ehret A, Scaffidi C, Peterhänsel C, Hofmann TG, Grummt I, Krammer PH, Peter ME. DEDD, a novel death effector domain-containing protein, targeted to the nucleolus. EMBO J. Oct 1998, 17 (20): 5974–86. PMC 1170924 . PMID 9774341. doi:10.1093/emboj/17.20.5974.
^ Alcivar A, Hu S, Tang J, Yang X. DEDD and DEDD2 associate with caspase-8/10 and signal cell death. Oncogene. Jan 2003, 22 (2): 291–7. PMID 12527898. doi:10.1038/sj.onc.1206099 .

延伸閱讀

Park MY, Ryu SW, Kim KD, Lim JS, Lee ZW, Kim E. Fas-associated factor-1 mediates chemotherapeutic-induced apoptosis via death effector filament formation. Int. J. Cancer. 2005, 115 (3): 412–8. PMID 15688372. doi:10.1002/ijc.20857 .
Alcivar A, Hu S, Tang J, Yang X. DEDD and DEDD2 associate with caspase-8/10 and signal cell death. Oncogene. 2003, 22 (2): 291–7. PMID 12527898. doi:10.1038/sj.onc.1206099 .
Lee JC, Schickling O, Stegh AH, Oshima RG, Dinsdale D, Cohen GM, Peter ME. DEDD regulates degradation of intermediate filaments during apoptosis. J. Cell Biol. 2002, 158 (6): 1051–66. PMC 2173221 . PMID 12235123. doi:10.1083/jcb.200112124.
Zhan Y, Hegde R, Srinivasula SM, Fernandes-Alnemri T, Alnemri ES. Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC. Cell Death Differ. 2002, 9 (4): 439–47. PMID 11965497. doi:10.1038/sj.cdd.4401038 .
Schickling O, Stegh AH, Byrd J, Peter ME. Nuclear localization of DEDD leads to caspase-6 activation through its death effector domain and inhibition of RNA polymerase I dependent transcription. Cell Death Differ. 2002, 8 (12): 1157–68. PMID 11753564. doi:10.1038/sj.cdd.4400928 .
Roth W, Stenner-Liewen F, Pawlowski K, Godzik A, Reed JC. Identification and characterization of DEDD2, a death effector domain-containing protein. J. Biol. Chem. 2002, 277 (9): 7501–8. PMID 11741985. doi:10.1074/jbc.M110749200 .

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000158796 – Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000013973 – Ensembl, 2017年5月

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9774341-5] 5.0 ^5.1 Stegh AH, Schickling O, Ehret A, Scaffidi C, Peterhänsel C, Hofmann TG, Grummt I, Krammer PH, Peter ME. DEDD, a novel death effector domain-containing protein, targeted to the nucleolus. EMBO J. Dec 1998, 17 (20): 5974–86. PMC 1170924 . PMID 9774341. doi:10.1093/emboj/17.20.5974.

[pmid9832420-6] Leo CP, Hsu SY, McGee EA, Salanova M, Hsueh AJ. DEFT, a novel death effector domain-containing molecule predominantly expressed in testicular germ cells. Endocrinology. Dec 1998, 139 (12): 4839–48. PMID 9832420. doi:10.1210/endo.139.12.6335 .

[entrez-7] Entrez Gene: DEDD death effector domain containing. [2024-03-15]. （原始內容存檔於2010-12-05）.

[entrez2-8] 引用錯誤：沒有為名為entrez2的參考文獻提供內容

[pmid11965497-9] 9.0 ^9.1 Zhan Y, Hegde R, Srinivasula SM, Fernandes-Alnemri T, Alnemri ES. Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC. Cell Death Differ. Apr 2002, 9 (4): 439–47. PMID 11965497. doi:10.1038/sj.cdd.4401038 .

[pmid11741985-10] 10.0 ^10.1 Roth W, Stenner-Liewen F, Pawlowski K, Godzik A, Reed JC. Identification and characterization of DEDD2, a death effector domain-containing protein. J. Biol. Chem. Mar 2002, 277 (9): 7501–8. PMID 11741985. doi:10.1074/jbc.M110749200 .

[autogenerated1-11] Stegh AH, Schickling O, Ehret A, Scaffidi C, Peterhänsel C, Hofmann TG, Grummt I, Krammer PH, Peter ME. DEDD, a novel death effector domain-containing protein, targeted to the nucleolus. EMBO J. Oct 1998, 17 (20): 5974–86. PMC 1170924 . PMID 9774341. doi:10.1093/emboj/17.20.5974.

[pmid12527898-12] Alcivar A, Hu S, Tang J, Yang X. DEDD and DEDD2 associate with caspase-8/10 and signal cell death. Oncogene. Jan 2003, 22 (2): 291–7. PMID 12527898. doi:10.1038/sj.onc.1206099 .

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