LRRK2

震顫素
已知的結構 PDB 直系同源搜索：PDBe RCSB PDBID列表 2ZEJ、3D6T
標識符
代號	LRRK2
擴展標識	OMIM：609007；MGI：1913975；HomoloGene：18982；GeneCards：LRRK2；OMA：LRRK2 - orthologs
EC編號	2.7.11.1
基因位置（人類） 染色體 12號染色體 基因座 12q12 起始 40,196,744 bp 終止 40,369,285 bp
基因位置（小鼠） 染色體 小鼠15號染色體 基因座 15|15 E3 起始 91,557,378 bp 終止 91,700,323 bp
RNA表達模式 Bgee 人類 小鼠（直系同源） Top expressed in buccal mucosa cell lower lobe of lung upper lobe of lung upper lobe of left lung right lung Top expressed in human kidney left lung left lung lobe right kidney lumbar spinal ganglion right lung 查閱更多表達數據 BioGPS 查閱更多表達數據
基因本體 分子功能 protein homodimerization activity signaling receptor complex adaptor activity clathrin binding co-receptor binding 轉移酶活性 GTPase activator activity 蛋白激酶活性 protein kinase A binding peroxidase inhibitor activity SNARE binding 核苷酸結合 相同蛋白質結合 GTPase activity syntaxin-1 binding 蛋白質絲氨酸/蘇氨酸激酶活性 tubulin binding transmembrane transporter binding microtubule binding MAP kinase kinase activity GTP binding ATP結合 GTP-dependent protein kinase activity beta-catenin destruction complex binding 血漿蛋白結合 激酶活性 actin binding magnesium ion binding 細胞組分 cytoplasmic vesicle 核內體 外排體 Wnt signalosome soma 反式高爾基網狀結構 mitochondrial membranes 突觸 細胞質 mitochondrial outer membrane synaptic vesicle membrane 細胞本體 內質網 細胞膜 微絨毛 線粒體基質 dendrite cytoplasm 生長錐 cell projection 樹突 溶酶體 neuron projection Golgi-associated vesicle 線粒體 mitochondrial inner membrane autolysosome 末梢神經 胞內 膜 脂筏模型 軸突 amphisome multivesicular body, internal vesicle 突觸小泡 包涵體 細胞連接 cytoplasmic side of mitochondrial outer membrane 細胞質基質 高爾基體 postsynapse 細胞外空間 細胞核 細胞內膜結合細胞器 caveola neck endoplasmic reticulum exit site glutamatergic synapse presynaptic cytosol 核糖核蛋白 生物學過程 lysosome organization response to oxidative stress cellular response to dopamine regulation of autophagy positive regulation of autophagy positive regulation of dopamine receptor signaling pathway regulation of neuroblast proliferation intracellular distribution of mitochondria negative regulation of protein processing negative regulation of protein processing involved in protein targeting to mitochondrion protein localization to mitochondrion positive regulation of canonical Wnt signaling pathway 自噬 neuromuscular junction development 磷酸化 positive regulation of protein binding regulation of branching morphogenesis of a nerve mitochondrion localization positive regulation of protein autoubiquitination regulation of synaptic vesicle transport positive regulation of protein phosphorylation regulation of kidney size regulation of synaptic vesicle exocytosis positive regulation of MAP kinase activity peptidyl-threonine phosphorylation MAPK cascade Wnt signalosome assembly protein phosphorylation regulation of synaptic transmission, glutamatergic 興奮性動作電位 negative regulation of hydrogen peroxide-induced cell death regulation of dopamine receptor signaling pathway regulation of membrane potential 自體磷酸化 regulation of mitochondrial fission regulation of neuron maturation reactive oxygen species metabolic process positive regulation of programmed cell death regulation of neuron death regulation of mitochondrial depolarization cellular response to oxidative stress negative regulation of late endosome to lysosome transport intracellular signal transduction regulation of lysosomal lumen pH negative regulation of GTPase activity locomotory exploration behavior Golgi organization canonical Wnt signaling pathway neuron projection morphogenesis positive regulation of protein ubiquitination regulation of canonical Wnt signaling pathway 探究行為 cellular response to organic cyclic compound tangential migration from the subventricular zone to the olfactory bulb regulation of protein kinase A signaling calcium-mediated signaling negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of proteasomal ubiquitin-dependent protein catabolic process negative regulation of neuron death negative regulation of protein targeting to mitochondrion peptidyl-serine phosphorylation determination of adult lifespan negative regulation of excitatory postsynaptic potential negative regulation of protein phosphorylation neuron death GTP metabolic process negative regulation of autophagosome assembly olfactory bulb development cellular response to starvation regulation of dendritic spine morphogenesis 細胞分化 內吞作用 negative regulation of protein binding mitochondrion organization cellular response to manganese ion negative regulation of macroautophagy regulation of locomotion positive regulation of GTPase activity regulation of retrograde transport, endosome to Golgi regulation of CAMKK-AMPK signaling cascade positive regulation of histone deacetylase activity endoplasmic reticulum organization 精子發生 基因調節 negative regulation of neuron projection development striatum development regulation of protein stability positive regulation of nitric-oxide synthase biosynthetic process regulation of ER to Golgi vesicle-mediated transport protein localization to endoplasmic reticulum exit site neuron projection arborization regulation of synaptic vesicle endocytosis positive regulation of synaptic vesicle endocytosis positive regulation of microglial cell activation protein import into nucleus 來源：Amigo / QuickGO
直系同源 物種 人類 小鼠 Entrez 120892 66725 Ensembl ENSG00000188906 ENSMUSG00000036273 UniProt Q5S007 Q5S006 mRNA序列 ​NM_198578 NM_025730 蛋白序列 NP_940980 NP_080006 基因位置 Chr 12：40.2 – 40.37 Mb Chr 15：91.56 – 91.7 Mb PubMed查詢
維基數據
檢視/編輯人類 檢視/編輯小鼠

LRRK2，（富亮氨酸重複激酶2（英語：Leucine-rich repeat kinase 2），又叫震顫素（英語：dardarin）），在人類是由PARK8基因編碼的一個酶。LRRK2是富亮氨酸重複激酶家族的一個成員。這個基因的變異與帕金森氏症和克隆氏症危險性增高相關。

功能

LRRK2基因編碼的蛋白擁有一個犰狳重複區域、一個錨蛋白重複區域、一個富亮氨酸重複結構域、一個激酶結構域、一個RAS結構域、一個鳥苷三磷酸酶結構域和一個WD40重複結構域。此蛋白大部分存在於細胞質中，但也與線粒體外膜結合。

LRRK2與Parkin連接酶C端RING(Really Interesting New Gene)指結構域有相互作用，而Parkin與LRRK2的COR結構域有相互作用。突變型LRRK2的表達誘導成神經細胞瘤和小鼠大腦皮質神經元的細胞凋亡。

外部連結

• GeneReviews/NCBI/NIH/UW entry on LRRK2-Related Parkinson Disease （頁面存檔備份，存於網際網路檔案館）
• 醫學主題詞表（MeSH）：LRRK2+protein,+human