TRAF3

TRAF3
已知的結構
PDB	直系同源搜索：PDBe RCSB
PDBID列表
	1FLK、1FLL、1KZZ、1L0A、1RF3、1ZMS、2ECY、2GKW
標識符
代號	TRAF3
擴展標識	OMIM：601896；MGI：108041；HomoloGene：7981；GeneCards：TRAF3；OMA：TRAF3 - orthologs
基因位置（人類）
染色體	14號染色體
終止	102,911,500 bp
基因位置（小鼠）
染色體	小鼠12號染色體
終止	111,233,587 bp
RNA表達模式
	Top expressed in
	cartilage tissue; ; BA46;
	Top expressed in
	CA3 field; ; vestibular sensory epithelium; ; Epithelium of choroid plexus; ; central gray substance of midbrain;
	查閱更多表達數據
	查閱更多表達數據
基因本體
分子功能	鋅離子結合; signal transducer activity; 金屬離子結合; 血漿蛋白結合; thioesterase binding; protein phosphatase binding; protein kinase binding; 泛素蛋白連接酶結合; 轉移酶活性; 泛素蛋白轉移酶活性; tumor necrosis factor receptor binding;
細胞組分	細胞質; 細胞質基質; 核內體; 線粒體; cytoplasmic side of plasma membrane; CD40 receptor complex; 大分子複合體;
生物學過程	regulation of apoptotic process; Toll signaling pathway; immune system process; TRIF-dependent toll-like receptor signaling pathway; protein ubiquitination; negative regulation of NF-kappaB transcription factor activity; regulation of proteolysis; 細胞凋亡; toll-like receptor signaling pathway; regulation of cytokine production; 訊息傳遞; regulation of interferon-beta production; 先天免疫系統; tumor necrosis factor-mediated signaling pathway; regulation of defense response to virus; protein deubiquitination;
	來源：Amigo / QuickGO
直系同源
	7187
	22031
	ENSG00000131323
	ENSMUSG00000021277
	Q13114
	Q60803
NM_001199427; NM_003300; NM_145725; NM_145726; NM_001385142;
	NM_001385143
	NM_001048206; NM_001286122; NM_011632; NM_001364364
	NP_001186356; NP_003291; NP_663777; NP_663778
	NP_001273051; NP_035762; NP_001351293
	維基數據
檢視/編輯人類	檢視/編輯小鼠

TRAF3（「TNF受體相關因子3」，TNF receptor associated factor 3）是人類基因 TRAF3 編碼的蛋白質，屬於一種TNF受體相關因子（TRAF）^[5]^[6]^[7]。

蛋白質的相互作用

TRAF3蛋白與下列蛋白質進行互作：

CD27^[8]^[9]
CD40^[10]^[11]^[12]^[13]
胱天蛋白酶3^[14]^[15]
Lymphotoxin beta receptor^[16]^[17]^[18]
Nucleoporin 62^[19]
RANK^[20]^[21]
TANK^[22]^[23]
TNFSF14^[24]

參考文獻

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000131323 – Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000021277 – Ensembl, 2017年5月
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cheng G, Cleary AM, Ye ZS, Hong DI, Lederman S, Baltimore D. Involvement of CRAF1, a relative of TRAF, in CD40 signaling. Science. March 1995, 267 (5203): 1494–8. Bibcode:1995Sci...267.1494C. PMID 7533327. S2CID 39062705. doi:10.1126/science.7533327.
^ Sato T, Irie S, Reed JC. A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40. FEBS Letters. January 1995, 358 (2): 113–8. PMID 7530216. S2CID 36111713. doi:10.1016/0014-5793(94)01406-Q.
^ Mosialos G, Birkenbach M, Yalamanchili R, VanArsdale T, Ware C, Kieff E. The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family. Cell. February 1995, 80 (3): 389–99. PMID 7859281. doi:10.1016/0092-8674(95)90489-1 .
^ Yamamoto H, Kishimoto T, Minamoto S. NF-kappaB activation in CD27 signaling: involvement of TNF receptor-associated factors in its signaling and identification of functional region of CD27. Journal of Immunology. November 1998, 161 (9): 4753–9. PMID 9794406. S2CID 22442601. doi:10.4049/jimmunol.161.9.4753.
^ Akiba H, Nakano H, Nishinaka S, Shindo M, Kobata T, Atsuta M, Morimoto C, Ware CF, Malinin NL, Wallach D, Yagita H, Okumura K. CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase. The Journal of Biological Chemistry. May 1998, 273 (21): 13353–8. PMID 9582383. doi:10.1074/jbc.273.21.13353 .
^ Tsukamoto N, Kobayashi N, Azuma S, Yamamoto T, Inoue J. Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40. Proceedings of the National Academy of Sciences of the United States of America. February 1999, 96 (4): 1234–9. Bibcode:1999PNAS...96.1234T. PMC 15446 . PMID 9990007. doi:10.1073/pnas.96.4.1234 .
^ Hu HM, O'Rourke K, Boguski MS, Dixit VM. A novel RING finger protein interacts with the cytoplasmic domain of CD40. The Journal of Biological Chemistry. December 1994, 269 (48): 30069–72. PMID 7527023. doi:10.1016/S0021-9258(18)43772-6 .
^ Ni CZ, Welsh K, Leo E, Chiou CK, Wu H, Reed JC, Ely KR. Molecular basis for CD40 signaling mediated by TRAF3. Proceedings of the National Academy of Sciences of the United States of America. September 2000, 97 (19): 10395–9. Bibcode:2000PNAS...9710395N. PMC 27035 . PMID 10984535. doi:10.1073/pnas.97.19.10395 .
^ Roy N, Deveraux QL, Takahashi R, Salvesen GS, Reed JC. The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. The EMBO Journal. December 1997, 16 (23): 6914–25. PMC 1170295 . PMID 9384571. doi:10.1093/emboj/16.23.6914.
^ Lee ZH, Lee SE, Kwack K, Yeo W, Lee TH, Bae SS, Suh PG, Kim HH. Caspase-mediated cleavage of TRAF3 in FasL-stimulated Jurkat-T cells. Journal of Leukocyte Biology. March 2001, 69 (3): 490–6. PMID 11261798. S2CID 34256107. doi:10.1189/jlb.69.3.490.
^ Leo E, Deveraux QL, Buchholtz C, Welsh K, Matsuzawa S, Stennicke HR, Salvesen GS, Reed JC. TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-alpha-induced apoptosis. The Journal of Biological Chemistry. March 2001, 276 (11): 8087–93. PMID 11098060. doi:10.1074/jbc.M009450200 .
^ VanArsdale TL, VanArsdale SL, Force WR, Walter BN, Mosialos G, Kieff E, Reed JC, Ware CF. Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB. Proceedings of the National Academy of Sciences of the United States of America. March 1997, 94 (6): 2460–5. Bibcode:1997PNAS...94.2460V. PMC 20110 . PMID 9122217. doi:10.1073/pnas.94.6.2460 .
^ Wu MY, Wang PY, Han SH, Hsieh SL. The cytoplasmic domain of the lymphotoxin-beta receptor mediates cell death in HeLa cells. The Journal of Biological Chemistry. April 1999, 274 (17): 11868–73. PMID 10207006. doi:10.1074/jbc.274.17.11868 .
^ Marsters SA, Ayres TM, Skubatch M, Gray CL, Rothe M, Ashkenazi A. Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1. The Journal of Biological Chemistry. May 1997, 272 (22): 14029–32. PMID 9162022. doi:10.1074/jbc.272.22.14029 .
^ Gamper C, van Eyndhoven WG, Schweiger E, Mossbacher M, Koo B, Lederman S. TRAF-3 interacts with p62 nucleoporin, a component of the nuclear pore central plug that binds classical NLS-containing import complexes. Molecular Immunology. 2000, 37 (1–2): 73–84. PMID 10781837. doi:10.1016/s0161-5890(00)00015-8.
^ Galibert L, Tometsko ME, Anderson DM, Cosman D, Dougall WC. The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily. The Journal of Biological Chemistry. December 1998, 273 (51): 34120–7. PMID 9852070. doi:10.1074/jbc.273.51.34120 .
^ Kim HH, Lee DE, Shin JN, Lee YS, Jeon YM, Chung CH, Ni J, Kwon BS, Lee ZH. Receptor activator of NF-kappaB recruits multiple TRAF family adaptors and activates c-Jun N-terminal kinase. FEBS Letters. January 1999, 443 (3): 297–302. PMID 10025951. S2CID 46210019. doi:10.1016/s0014-5793(98)01731-1 .
^ Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G. A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. Nature Cell Biology. February 2004, 6 (2): 97–105. PMID 14743216. S2CID 11683986. doi:10.1038/ncb1086.
^ Rothe M, Xiong J, Shu HB, Williamson K, Goddard A, Goeddel DV. I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction. Proceedings of the National Academy of Sciences of the United States of America. August 1996, 93 (16): 8241–6. Bibcode:1996PNAS...93.8241R. PMC 38654 . PMID 8710854. doi:10.1073/pnas.93.16.8241 .
^ Kuai J, Nickbarg E, Wooters J, Qiu Y, Wang J, Lin LL. Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis. The Journal of Biological Chemistry. April 2003, 278 (16): 14363–9. PMID 12571250. doi:10.1074/jbc.M208672200 .

外部連結

醫學主題詞表（MeSH）：TRAF3

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000131323 – Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000021277 – Ensembl, 2017年5月

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Cheng G, Cleary AM, Ye ZS, Hong DI, Lederman S, Baltimore D. Involvement of CRAF1, a relative of TRAF, in CD40 signaling. Science. March 1995, 267 (5203): 1494–8. Bibcode:1995Sci...267.1494C. PMID 7533327. S2CID 39062705. doi:10.1126/science.7533327.

[pmid7530216-6] Sato T, Irie S, Reed JC. A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40. FEBS Letters. January 1995, 358 (2): 113–8. PMID 7530216. S2CID 36111713. doi:10.1016/0014-5793(94)01406-Q.

[pmid7859281-7] Mosialos G, Birkenbach M, Yalamanchili R, VanArsdale T, Ware C, Kieff E. The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family. Cell. February 1995, 80 (3): 389–99. PMID 7859281. doi:10.1016/0092-8674(95)90489-1 .

[pmid9794406-8] Yamamoto H, Kishimoto T, Minamoto S. NF-kappaB activation in CD27 signaling: involvement of TNF receptor-associated factors in its signaling and identification of functional region of CD27. Journal of Immunology. November 1998, 161 (9): 4753–9. PMID 9794406. S2CID 22442601. doi:10.4049/jimmunol.161.9.4753.

[pmid9582383-9] Akiba H, Nakano H, Nishinaka S, Shindo M, Kobata T, Atsuta M, Morimoto C, Ware CF, Malinin NL, Wallach D, Yagita H, Okumura K. CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase. The Journal of Biological Chemistry. May 1998, 273 (21): 13353–8. PMID 9582383. doi:10.1074/jbc.273.21.13353 .

[pmid9990007-10] Tsukamoto N, Kobayashi N, Azuma S, Yamamoto T, Inoue J. Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40. Proceedings of the National Academy of Sciences of the United States of America. February 1999, 96 (4): 1234–9. Bibcode:1999PNAS...96.1234T. PMC 15446 . PMID 9990007. doi:10.1073/pnas.96.4.1234 .

[pmid7527023-11] Hu HM, O'Rourke K, Boguski MS, Dixit VM. A novel RING finger protein interacts with the cytoplasmic domain of CD40. The Journal of Biological Chemistry. December 1994, 269 (48): 30069–72. PMID 7527023. doi:10.1016/S0021-9258(18)43772-6 .

[pmid10984535-12] Ni CZ, Welsh K, Leo E, Chiou CK, Wu H, Reed JC, Ely KR. Molecular basis for CD40 signaling mediated by TRAF3. Proceedings of the National Academy of Sciences of the United States of America. September 2000, 97 (19): 10395–9. Bibcode:2000PNAS...9710395N. PMC 27035 . PMID 10984535. doi:10.1073/pnas.97.19.10395 .

[pmid9384571-13] Roy N, Deveraux QL, Takahashi R, Salvesen GS, Reed JC. The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. The EMBO Journal. December 1997, 16 (23): 6914–25. PMC 1170295 . PMID 9384571. doi:10.1093/emboj/16.23.6914.

[pmid11261798-14] Lee ZH, Lee SE, Kwack K, Yeo W, Lee TH, Bae SS, Suh PG, Kim HH. Caspase-mediated cleavage of TRAF3 in FasL-stimulated Jurkat-T cells. Journal of Leukocyte Biology. March 2001, 69 (3): 490–6. PMID 11261798. S2CID 34256107. doi:10.1189/jlb.69.3.490.

[pmid11098060-15] Leo E, Deveraux QL, Buchholtz C, Welsh K, Matsuzawa S, Stennicke HR, Salvesen GS, Reed JC. TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-alpha-induced apoptosis. The Journal of Biological Chemistry. March 2001, 276 (11): 8087–93. PMID 11098060. doi:10.1074/jbc.M009450200 .

[pmid9122217-16] VanArsdale TL, VanArsdale SL, Force WR, Walter BN, Mosialos G, Kieff E, Reed JC, Ware CF. Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB. Proceedings of the National Academy of Sciences of the United States of America. March 1997, 94 (6): 2460–5. Bibcode:1997PNAS...94.2460V. PMC 20110 . PMID 9122217. doi:10.1073/pnas.94.6.2460 .

[pmid10207006-17] Wu MY, Wang PY, Han SH, Hsieh SL. The cytoplasmic domain of the lymphotoxin-beta receptor mediates cell death in HeLa cells. The Journal of Biological Chemistry. April 1999, 274 (17): 11868–73. PMID 10207006. doi:10.1074/jbc.274.17.11868 .

[pmid9162022-18] Marsters SA, Ayres TM, Skubatch M, Gray CL, Rothe M, Ashkenazi A. Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1. The Journal of Biological Chemistry. May 1997, 272 (22): 14029–32. PMID 9162022. doi:10.1074/jbc.272.22.14029 .

[pmid10781837-19] Gamper C, van Eyndhoven WG, Schweiger E, Mossbacher M, Koo B, Lederman S. TRAF-3 interacts with p62 nucleoporin, a component of the nuclear pore central plug that binds classical NLS-containing import complexes. Molecular Immunology. 2000, 37 (1–2): 73–84. PMID 10781837. doi:10.1016/s0161-5890(00)00015-8.

[pmid9852070-20] Galibert L, Tometsko ME, Anderson DM, Cosman D, Dougall WC. The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily. The Journal of Biological Chemistry. December 1998, 273 (51): 34120–7. PMID 9852070. doi:10.1074/jbc.273.51.34120 .

[pmid10025951-21] Kim HH, Lee DE, Shin JN, Lee YS, Jeon YM, Chung CH, Ni J, Kwon BS, Lee ZH. Receptor activator of NF-kappaB recruits multiple TRAF family adaptors and activates c-Jun N-terminal kinase. FEBS Letters. January 1999, 443 (3): 297–302. PMID 10025951. S2CID 46210019. doi:10.1016/s0014-5793(98)01731-1 .

[pmid14743216-22] Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G. A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. Nature Cell Biology. February 2004, 6 (2): 97–105. PMID 14743216. S2CID 11683986. doi:10.1038/ncb1086.

[pmid8710854-23] Rothe M, Xiong J, Shu HB, Williamson K, Goddard A, Goeddel DV. I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction. Proceedings of the National Academy of Sciences of the United States of America. August 1996, 93 (16): 8241–6. Bibcode:1996PNAS...93.8241R. PMC 38654 . PMID 8710854. doi:10.1073/pnas.93.16.8241 .

[pmid12571250-24] Kuai J, Nickbarg E, Wooters J, Qiu Y, Wang J, Lin LL. Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis. The Journal of Biological Chemistry. April 2003, 278 (16): 14363–9. PMID 12571250. doi:10.1074/jbc.M208672200 .

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