TRAF4

TRAF4
已知的結構
PDB	直系同源搜索：PDBe RCSB
PDBID列表
	2EOD、2YUC、3ZJB、4K8U、4M4E
標識符
代號	TRAF4
擴展標識	OMIM：602464；MGI：1202880；HomoloGene：3173；GeneCards：TRAF4；OMA：TRAF4 - orthologs
基因位置（人類）
染色體	17號染色體
終止	28,750,956 bp
基因位置（小鼠）
染色體	小鼠11號染色體
終止	78,056,415 bp
RNA表達模式
	Top expressed in
	olfactory zone of nasal mucosa; ; right uterine tube; ; mucosa of transverse colon; ; right lobe of thyroid gland; ; minor salivary glands; ; left lobe of thyroid gland; ; right lobe of liver; ; ganglionic eminence;
	Top expressed in
	right kidney; ; ganglionic eminence; ; ventricular zone; ; mandibular prominence;
	查閱更多表達數據
	; ;
	查閱更多表達數據
基因本體
分子功能	DNA結合; 鋅離子結合; 金屬離子結合; 血漿蛋白結合; WW domain binding; thioesterase binding; tumor necrosis factor receptor binding; protein kinase binding; 泛素蛋白連接酶結合; 相同蛋白質結合;
細胞組分	細胞質; 膜; 雙細胞緊密連接; 細胞膜; 細胞連接; 細胞質的核周區域; 細胞骨架; 細胞核; 大分子複合體; 胞內;
生物學過程	regulation of apoptotic process; activation of NF-kappaB-inducing kinase activity; positive regulation of JNK cascade; positive regulation of protein homodimerization activity; respiratory gaseous exchange by respiratory system; multicellular organism development; respiratory tube development; 訊息傳遞; positive regulation of protein kinase activity; 細胞凋亡;
	來源：Amigo / QuickGO
直系同源
	9618
	22032
	ENSG00000076604
	ENSMUSG00000017386
	Q9BUZ4
	Q61382
	NM_004295; NM_145751
	NM_009423
	NP_004286
	NP_033449
	維基數據
檢視/編輯人類	檢視/編輯小鼠

TRAF4（「TNF受體相關因子4」，TNF receptor associated factor 4，也稱為「環指因子83」，RING finger protein 83，縮寫「RNF83」）是人類基因 TRAF4 編碼的蛋白質，屬於一種TNF受體相關因子（TRAF）。

蛋白質的相互作用

TRAF4蛋白與下列蛋白質進行互作：

神經生長因子受體 p75（NTR/NTSR1）^[5]^[6]

參考文獻

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000076604 – Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000017386 – Ensembl, 2017年5月
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ye X, Mehlen P, Rabizadeh S, VanArsdale T, Zhang H, Shin H, Wang JJ, Leo E, Zapata J, Hauser CA, Reed JC, Bredesen DE. TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction. J. Biol. Chem. October 1999, 274 (42): 30202–8. PMID 10514511. doi:10.1074/jbc.274.42.30202 .
^ Krajewska M, Krajewski S, Zapata JM, Van Arsdale T, Gascoyne RD, Berern K, McFadden D, Shabaik A, Hugh J, Reynolds A, Clevenger CV, Reed JC. TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues. Am. J. Pathol. June 1998, 152 (6): 1549–61. PMC 1858434 . PMID 9626059.

外部連結

醫學主題詞表（MeSH）：TRAF4

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000076604 – Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000017386 – Ensembl, 2017年5月

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10514511-5] Ye X, Mehlen P, Rabizadeh S, VanArsdale T, Zhang H, Shin H, Wang JJ, Leo E, Zapata J, Hauser CA, Reed JC, Bredesen DE. TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction. J. Biol. Chem. October 1999, 274 (42): 30202–8. PMID 10514511. doi:10.1074/jbc.274.42.30202 .

[pmid9626059-6] Krajewska M, Krajewski S, Zapata JM, Van Arsdale T, Gascoyne RD, Berern K, McFadden D, Shabaik A, Hugh J, Reynolds A, Clevenger CV, Reed JC. TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues. Am. J. Pathol. June 1998, 152 (6): 1549–61. PMC 1858434 . PMID 9626059.

[1]

[2]

[3]

[4]

[5]

[6]