ADCY7

ADCY7
標識符
代號	ADCY7
擴展標識	OMIM：600385；MGI：102891；HomoloGene：866；GeneCards：ADCY7；OMA：ADCY7 - orthologs
基因位置（人類） 染色體 16號染色體 基因座 16q12.1 起始 50,246,137 bp 終止 50,318,135 bp
基因位置（小鼠） 染色體 小鼠8號染色體 基因座 8 C3|8 43.06 cM 起始 88,999,031 bp 終止 89,056,590 bp
RNA表達模式 Bgee 人類 小鼠（直系同源） Top expressed in skin of hip Top expressed in tunica media of zone of aorta fetal liver hematopoietic progenitor cell 查閱更多表達數據 BioGPS 查閱更多表達數據
基因本體 分子功能 adenylate cyclase activity ATP結合 phosphorus-oxygen lyase activity 金屬離子結合 核苷酸結合 lyase activity guanylate cyclase activity 細胞組分 integral component of membrane 膜 細胞膜 guanylate cyclase complex, soluble 胞內 integral component of plasma membrane 生物學過程 renal water homeostasis intracellular signal transduction cellular response to ethanol cellular response to glucagon stimulus cyclic nucleotide biosynthetic process maternal process involved in female pregnancy cGMP biosynthetic process 信號轉導 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway cAMP biosynthetic process adenylate cyclase-activating G protein-coupled receptor signaling pathway regulation of adaptive immune response cellular response to lithium ion negative regulation of cytokine production involved in inflammatory response activation of adenylate cyclase activity activation of protein kinase A activity 來源：Amigo / QuickGO
直系同源 物種 人類 小鼠 Entrez 113 11513 Ensembl ENSG00000121281 ENSMUSG00000031659 UniProt P51828 P51829 mRNA序列 NM_001114 ​NM_001286057 NM_001037723 ​NM_001037724 ​NM_001109756 ​NM_007406 蛋白序列 NP_001105 ​NP_001272986 NP_001032812 ​NP_001032813 ​NP_001103226 ​NP_031432 基因位置 Chr 16：50.25 – 50.32 Mb Chr 8：89 – 89.06 Mb PubMed查詢
維基數據
檢視/編輯人類 檢視/編輯小鼠

腺苷酰環化酶7（英語：Adenylyl cyclase type 7）化學式為：C₅₆₉₄H₉₀₃₄O₁₇₂₁N₁₄₉₀S₇₀，是人類ADCY7基因編碼的一個酶。

功能

這個基因編碼與膜結合催化從三磷酸腺苷形成環腺苷酸的腺苷酰環化酶，此過程被鈣質抑制。這個基因的產物是腺苷酰環化酶4類/鳥苷酰環化酶家族的一個成員，特點是有個12跨膜結構域。

延申閱讀

• Nomura N, Miyajima N, Sazuka T, et al. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. DNA Res. 1995, 1 (1): 27–35. PMID 7584026. doi:10.1093/dnares/1.1.27 . 
• Nomura N, Miyajima N, Sazuka T, et al. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement). DNA Res. 1995, 1 (1): 47–56. PMID 7584028. doi:10.1093/dnares/1.1.47 . 
• Hellevuo K, Welborn R, Menninger JA, Tabakoff B. Human adenylyl cyclase type 7 contains polymorphic repeats in the 3' untranslated region: investigations of association with alcoholism. Am. J. Med. Genet. 1997, 74 (1): 95–8. PMID 9034014. doi:10.1002/(SICI)1096-8628(19970221)74:1<95::AID-AJMG19>3.0.CO;2-M. 
• Barcova M, Speth C, Kacani L, et al. Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1. Pflügers Arch. 1999, 437 (4): 538–46. PMID 10089566. S2CID 7620262. doi:10.1007/s004240050815. 
• Speth C, Joebstl B, Barcova M, Dierich MP. HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones. AIDS. 2000, 14 (6): 629–36. PMID 10807185. S2CID 22105709. doi:10.1097/00002030-200004140-00001. 
• Patke CL, Shearer WT. gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression. J. Allergy Clin. Immunol. 2000, 105 (5): 975–82. PMID 10808179. doi:10.1067/mai.2000.105315. 
• Patrizio M, Colucci M, Levi G. Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures. J. Neurochem. 2001, 77 (2): 399–407. PMID 11299302. S2CID 24053412. doi:10.1046/j.1471-4159.2001.00249.x . 
• Yan SZ, Tang WJ. Construction of soluble adenylyl cyclase from human membrane-bound type 7 adenylyl cyclase. G Protein Pathways - Part C, Effector Mechanisms. Methods in Enzymology 345. 2002: 231–41. ISBN 978-0-12-182246-0. PMID 11665607. doi:10.1016/S0076-6879(02)45019-7. 
• Speth C, Schabetsberger T, Mohsenipour I, et al. Mechanism of Human Immunodeficiency Virus-Induced Complement Expression in Astrocytes and Neurons. J. Virol. 2002, 76 (7): 3179–88. PMC 136041 . PMID 11884542. doi:10.1128/JVI.76.7.3179-3188.2002. 
• Nelson EJ, Hellevuo K, Yoshimura M, Tabakoff B. Ethanol-induced phosphorylation and potentiation of the activity of type 7 adenylyl cyclase. Involvement of protein kinase C delta. J. Biol. Chem. 2003, 278 (7): 4552–60. PMID 12454008. doi:10.1074/jbc.M210386200 . 
• Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899. 
• Ludwig MG, Seuwen K. Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms. J. Recept. Signal Transduct. Res. 2003, 22 (1–4): 79–110. PMID 12503609. S2CID 36697419. doi:10.1081/RRS-120014589. 
• Ota T, Suzuki Y, Nishikawa T, et al. Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. 2004, 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285 . 
• Gerhard DS, Wagner L, Feingold EA, et al. The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC). Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504. 
• Beeler JA, Yan SZ, Bykov S, et al. A soluble C1b protein and its regulation of soluble type 7 adenylyl cyclase. Biochemistry. 2005, 43 (49): 15463–71. CiteSeerX 10.1.1.558.7519 . PMID 15581358. doi:10.1021/bi049088+. 
• Kimura K, Wakamatsu A, Suzuki Y, et al. Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes. Genome Res. 2006, 16 (1): 55–65. PMC 1356129 . PMID 16344560. doi:10.1101/gr.4039406. 
• Hines LM, Hoffman PL, Bhave S, et al. A sex-specific role of type VII adenylyl cyclase in depression. J. Neurosci. 2006, 26 (48): 12609–19. PMC 6674903 . PMID 17135423. doi:10.1523/JNEUROSCI.1040-06.2006 .