LY-293284

LY-293284
臨床資料
其他名稱	LY293284
藥物類別	Serotonin 5-HT1A receptor agonist; Simplified/partial LSD analogue
識別資訊
	IUPAC命名法 (4R)-6-acetyl-4-(di-n-propylamino)-1,3,4,5-tetrahydrobenz[c,d]indole; ;
CAS號	141318-62-9
PubChem CID	132345;
IUPHAR/BPS	19;
ChemSpider	116875;
UNII	92MME29XHM;
CompTox Dashboard (EPA)	DTXSID70161692 ;
化學資訊
化學式	C19H26N2O
摩爾質量	298.43 g·mol−1
3D模型（JSmol）	交互式圖像;
	SMILES CCCN(CCC)[C@H]1CC2=CNC3=C2C(=C(C=C3)C(=O)C)C1;
	InChI InChI=1S/C19H26N2O/c1-4-8-21(9-5-2)15-10-14-12-20-18-7-6-16(13(3)22)17(11-15)19(14)18/h6-7,12,15,20H,4-5,8-11H2,1-3H3/t15-/m0/s1; Key:CKYZLYQSDNLGPT-HNNXBMFYSA-N;

LY-293284是一種含氮有機化合物，分子式C
19H
26N
2O，可作為5-HT_1A受體的完全激動劑，由禮來公司開發^[1]，動物實驗表明其具有致焦慮作用^[2]。

參考文獻

^ Monte AP, Marona-Lewicka D, Lewis MM, Mailman RB, Wainscott DB, Nelson DL, Nichols DE. Substituted naphthofurans as hallucinogenic phenethylamine-ergoline hybrid molecules with unexpected muscarinic antagonist activity. Journal of Medicinal Chemistry. June 1998, 41 (12): 2134–45. PMID 9622555. doi:10.1021/jm980076u.
^ Cao BJ, Rodgers RJ. Comparative effects of novel 5-HT1A receptor ligands, LY293284, LY315712 and LY297996, on plus-maze anxiety in mice. Psychopharmacology. October 1998, 139 (3): 185–94. PMID 9784072. S2CID 9466299. doi:10.1007/s002130050703.