MYO1F

MYO1F
標識符
代號	MYO1F
擴展標識	OMIM：601480；MGI：107711；HomoloGene：56276；GeneCards：MYO1F；OMA：MYO1F - orthologs
基因位置（人類）
染色體	19號染色體
終止	8,577,577 bp
基因位置（小鼠）
染色體	小鼠17號染色體
終止	33,826,738 bp
RNA表現模式
	Top expressed in
	right lung; ; upper lobe of left lung;
	Top expressed in
	stroma of bone marrow; ; lumbar spinal ganglion; ; subcutaneous adipose tissue; ; right lung lobe;
	查閱更多表現資料
	查閱更多表現資料
基因本體
分子功能	核苷酸結合; actin binding; cytoskeletal motor activity; ATP結合; calmodulin binding; microtubule motor activity; microtubule binding;
細胞組分	unconventional myosin complex; myosin complex;
生物學過程	生物過程; microtubule-based movement;
	來源：Amigo / QuickGO
直系同源
	4542
	17916
	ENSG00000142347
	ENSMUSG00000024300
	O00160
	P70248
	NM_012335; NM_001348355
	NM_053214
	NP_036467; NP_001335284
	無資料
	維基數據
檢視/編輯人類	檢視/編輯小鼠

MYO1F (化學式為：C₅₅₄₃H₈₇₂₆O₁₆₂₂N₁₅₉₀S₃₉^[5])是一個位於人類17號染色體上的基因，該編碼是一種隸屬於肌凝蛋白超家族的蛋白肌凝蛋白-If（Myosin-If）。MYO1F編碼的肌凝蛋白-If是一種非典型的肌凝蛋白，與編碼肌凝蛋白-1MYH1是兩種不同的基因。^[6]^[7]^[8]^[9]

MYO1F基因主要在免疫系統中表現，其功能主要與細胞黏附，細胞移動有關^[10]。而該基因的突變則與非症候群性耳聾有關^[11]。

參見

肌凝蛋白

參考資料

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000142347 – Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000024300 – Ensembl, 2017年5月
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Expasy - ProtParam. web.expasy.org. [2026-02-13].
^ MYO1F Gene. GeneCards. [2021-05-02]. （原始內容存檔於2021-06-04）.
^ Crozet F, el Amraoui A, Blanchard S, Lenoir M, Ripoll C, Vago P, Hamel C, Fizames C, Levi-Acobas F, Depetris D, Mattei MG, Weil D, Pujol R, Petit C. Cloning of the genes encoding two murine and human cochlear unconventional type I myosins. Genomics. Apr 1997, 40 (2): 332–41. PMID 9119401. doi:10.1006/geno.1996.4526.
^ Hasson T, Skowron JF, Gilbert DJ, Avraham KB, Perry WL, Bement WM, Anderson BL, Sherr EH, Chen ZY, Greene LA, Ward DC, Corey DP, Mooseker MS, Copeland NG, Jenkins NA. Mapping of unconventional myosins in mouse and human. Genomics. Feb 1997, 36 (3): 431–9. PMID 8884266. doi:10.1006/geno.1996.0488.
^ Entrez Gene: MYO1F myosin IF. [2021-05-02]. （原始內容存檔於2010-12-05）.
^ Kim SV, Mehal WZ, Dong X, Heinrich V, Pypaert M, Mellman I, Dembo M, Mooseker MS, Wu D, Flavell RA. Modulation of cell adhesion and motility in the immune system by Myo1f. Science. October 2006, 314 (5796): 136–9. PMID 17023661. doi:10.1126/science.1131920.
^ Chen AH, Stephan DA, Hasson T, Fukushima K, Nelissen CM, Chen AF, Jun AI, Ramesh A, Van Camp G, Smith RJ. MYO1F as a candidate gene for nonsyndromic deafness, DFNB15. Arch. Otolaryngol. Head Neck Surg. August 2001, 127 (8): 921–5. PMID 11493199. doi:10.1001/archotol.127.8.921.

拓展閱讀

Bement WM, Hasson T, Wirth JA, et al. Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types. Proc. Natl. Acad. Sci. U.S.A. 1994, 91 (14): 6549–53. PMC 44240 . PMID 8022818. doi:10.1073/pnas.91.14.6549.
Krugmann S, Anderson KE, Ridley SH, et al. Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices. Mol. Cell. 2002, 9 (1): 95–108. PMID 11804589. doi:10.1016/S1097-2765(02)00434-3.
Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Ota T, Suzuki Y, Nishikawa T, et al. Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. 2004, 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Gerhard DS, Wagner L, Feingold EA, et al. The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC). Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Rual JF, Venkatesan K, Hao T, et al. Towards a proteome-scale map of the human protein-protein interaction network. Nature. 2005, 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209.
Olsen JV, Blagoev B, Gnad F, et al. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell. 2006, 127 (3): 635–48. PMID 17081983. doi:10.1016/j.cell.2006.09.026.

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[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000142347 – Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000024300 – Ensembl, 2017年5月

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Expasy - ProtParam. web.expasy.org. [2026-02-13].

[6] MYO1F Gene. GeneCards. [2021-05-02]. （原始內容存檔於2021-06-04）.

[pmid9119401-7] Crozet F, el Amraoui A, Blanchard S, Lenoir M, Ripoll C, Vago P, Hamel C, Fizames C, Levi-Acobas F, Depetris D, Mattei MG, Weil D, Pujol R, Petit C. Cloning of the genes encoding two murine and human cochlear unconventional type I myosins. Genomics. Apr 1997, 40 (2): 332–41. PMID 9119401. doi:10.1006/geno.1996.4526.

[pmid8884266-8] Hasson T, Skowron JF, Gilbert DJ, Avraham KB, Perry WL, Bement WM, Anderson BL, Sherr EH, Chen ZY, Greene LA, Ward DC, Corey DP, Mooseker MS, Copeland NG, Jenkins NA. Mapping of unconventional myosins in mouse and human. Genomics. Feb 1997, 36 (3): 431–9. PMID 8884266. doi:10.1006/geno.1996.0488.

[entrez-9] Entrez Gene: MYO1F myosin IF. [2021-05-02]. （原始內容存檔於2010-12-05）.

[pmid17023661-10] Kim SV, Mehal WZ, Dong X, Heinrich V, Pypaert M, Mellman I, Dembo M, Mooseker MS, Wu D, Flavell RA. Modulation of cell adhesion and motility in the immune system by Myo1f. Science. October 2006, 314 (5796): 136–9. PMID 17023661. doi:10.1126/science.1131920.

[pmid11493199-11] Chen AH, Stephan DA, Hasson T, Fukushima K, Nelissen CM, Chen AF, Jun AI, Ramesh A, Van Camp G, Smith RJ. MYO1F as a candidate gene for nonsyndromic deafness, DFNB15. Arch. Otolaryngol. Head Neck Surg. August 2001, 127 (8): 921–5. PMID 11493199. doi:10.1001/archotol.127.8.921.

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