PHCCC

PHCCC
識別資訊
	IUPAC命名法 (−)-N-Phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxamide; ;
CAS號	179068-02-1
PubChem CID	3579925;
ChemSpider	2816644;
化學資訊
化學式	C17H14N2O3
摩爾質量	294.31 g·mol−1
3D模型（JSmol）	交互式圖像;
	SMILES c4ccccc4NC(=O)C1(CC1C2=NO)Oc3ccccc23;
	InChI InChI=1S/C17H14N2O3/c20-16(18-11-6-2-1-3-7-11)17-10-13(17)15(19-21)12-8-4-5-9-14(12)22-17/h1-9,13,21H,10H2,(H,18,20); Key:FPXPIEZPAXSELW-UHFFFAOYSA-N;

PHCCC是一種作為穀氨酸受體（英語：glutamate receptor）配體的研究藥物，可以作為mGluR₄（英語：Metabotropic glutamate receptor 4）的正向變構調節劑^[1]和mGluR₆的激動劑。^[2]動物研究表明，它具有抗焦慮作用。^[3]它和類似藥物被提議用於治療帕金森病。^[4]

參考文獻

^ Maj M, Bruno V, Dragic Z, Yamamoto R, Battaglia G, Inderbitzin W, Stoehr N, Stein T, Gasparini F, Vranesic I, Kuhn R, Nicoletti F, Flor PJ. (−)-PHCCC, a positive allosteric modulator of mGluR4: characterization, mechanism of action, and neuroprotection. Neuropharmacology. December 2003, 45 (7): 895–906. PMID 14573382. S2CID 17446511. doi:10.1016/S0028-3908(03)00271-5.
^ Beqollari D, Kammermeier PJ. The mGlu(4) receptor allosteric modulator N-phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxamide acts as a direct agonist at mGlu(6) receptors. European Journal of Pharmacology. July 2008, 589 (1–3): 49–52. PMID 18593581. doi:10.1016/j.ejphar.2008.06.054.
^ Stachowicz K, Kłak K, Kłodzińska A, Chojnacka-Wojcik E, Pilc A. Anxiolytic-like effects of PHCCC, an allosteric modulator of mGlu4 receptors, in rats. European Journal of Pharmacology. September 2004, 498 (1–3): 153–6. PMID 15363989. doi:10.1016/j.ejphar.2004.07.001.
^ Niswender CM, Johnson KA, Weaver CD, Jones CK, Xiang Z, Luo Q, Rodriguez AL, Marlo JE, de Paulis T, Thompson AD, Days EL, Nalywajko T, Austin CA, Williams MB, Ayala JE, Williams R, Lindsley CW, Conn PJ. Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4. Molecular Pharmacology. November 2008, 74 (5): 1345–58. PMC 2574552 . PMID 18664603. doi:10.1124/mol.108.049551.

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