ERA-63

ERA-63
臨床資料
其他名稱	3-Methylene-7α-methylethinylestradiol; 3-Methylene-7α-methyl-17α-ethynylestra-5(10)-en-17β-ol
识别信息
	IUPAC命名法 (7R,8R,9S,13S,14S,17R)-17-Ethynyl-7,13-dimethyl-3-methylidene-1,2,4,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-ol; ;
CAS号	343248-86-2
PubChem CID	87921126;
ChemSpider	8058857;
化学信息
化学式	C22H30O
摩尔质量	310.48 g·mol−1
3D模型（JSmol）	交互式图像;
	SMILES C[C@@H]1CC2=C(CCC(=C)C2)[C@@H]3[C@@H]1[C@@H]4CC[C@]([C@]4(CC3)C)(C#C)O;
	InChI InChI=1S/C22H30O/c1-5-22(23)11-9-19-20-15(3)13-16-12-14(2)6-7-17(16)18(20)8-10-21(19,22)4/h1,15,18-20,23H,2,6-13H2,3-4H3/t15-,18-,19+,20-,21+,22+/m1/s1; Key:ITYURVXIFIQGDB-LADQHVHVSA-N;

ERA-63或ORG-37663，化学名3-亚甲基-7α-甲基-17α-乙炔基雌甾-5(10)-烯-17β-醇（英語：3-methylene-7α-methyl-17α-ethynylestra-5(10)-en-17β-ol）是一种人工合成的甾体雌激素，分子式C
22H
30O，为治疗類風濕性關節炎而开发，从未上市销售^[1]^[2]。

参考文献

^ ^1.0 ^1.1 Janssen GB, Penninks AH, Knippels LM, van Zijverden M, Spanhaak S. The evaluation of the immunomodulating properties of ERA-63 a pharmaceutical with estrogenic activity. Toxicol. Lett. 2008, 180 (3): 196–201. PMID 18602456. doi:10.1016/j.toxlet.2008.06.857.
^ Dulos J, Hofstra CL, Joosten L, Veening-Griffioen DH, Lucassen MA, Doorn CM, Graaf JH, Miltenburg A, Dijcks FA, Ederveen TH, Boots AM. A selective estrogen receptor alpha agonist (Org 37663) suppresses inflammation and arthritis in mouse models. Annals of the Rheumatic Diseases. 2006, 65: 128.

[pmid18602456-1] 1.0 ^1.1 Janssen GB, Penninks AH, Knippels LM, van Zijverden M, Spanhaak S. The evaluation of the immunomodulating properties of ERA-63 a pharmaceutical with estrogenic activity. Toxicol. Lett. 2008, 180 (3): 196–201. PMID 18602456. doi:10.1016/j.toxlet.2008.06.857.

[DulosHofstra2006-2] Dulos J, Hofstra CL, Joosten L, Veening-Griffioen DH, Lucassen MA, Doorn CM, Graaf JH, Miltenburg A, Dijcks FA, Ederveen TH, Boots AM. A selective estrogen receptor alpha agonist (Org 37663) suppresses inflammation and arthritis in mouse models. Annals of the Rheumatic Diseases. 2006, 65: 128.

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