HTN1

HTN1
标识符
代号	HTN1
扩展标识	OMIM：142701；HomoloGene：88658；GeneCards：HTN1；OMA：HTN1 - orthologs
基因位置（人类） 染色体 4號染色體 基因座 4q13.3 起始 70,050,438 bp 终止 70,058,848 bp
RNA表达模式 Bgee 人类 小鼠（直系同源） Top expressed in olfactory zone of nasal mucosa minor salivary glands skeletal muscle tissue 无数据 查阅更多表达数据 BioGPS 查阅更多表达数据
基因本體 分子功能 血浆蛋白结合 細胞組分 細胞外區域 細胞外空間 生物學過程 biomineral tissue development defense response to bacterium defense response to fungus antimicrobial humoral response killing of cells of other organism 来源：Amigo / QuickGO
直系同源 物種 人類 小鼠 Entrez 3346 无数据 Ensembl ENSG00000283046 ​ENSG00000126550 无数据 UniProt P15515 无数据 mRNA序列 NM_002159 ​NM_001368990 无数据 蛋白序列 NP_002150 ​NP_001355919 无数据 基因位置 Chr 4：70.05 – 70.06 Mb 无数据 PubMed查询 无数据
维基数据
檢視/編輯人類

組氨素1（英語：Histatin-1），是一類由HTN1基因編碼的蛋白質，其编码的組氨素1还能降解为組氨素2。組氨素1化学式为：C₁₅₈H₂₁₁O₄₄N₄₅

等位基因	基因	蛋白質
HIS1	HTN1	組氨素 1 → 組氨素 2
HIS2	HTN3	組氨素 3 → 組氨素 4-6

延伸阅读

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• Sabatini LM, Azen EA. Histatins, a family of salivary histidine-rich proteins, are encoded by at least two loci (HIS1 and HIS2).. Biochem. Biophys. Res. Commun. 1989, 160 (2): 495–502. PMID 2719677. doi:10.1016/0006-291X(89)92460-1. 
• vanderSpek JC, Wyandt HE, Skare JC; et al. Localization of the genes for histatins to human chromosome 4q13 and tissue distribution of the mRNAs.. Am. J. Hum. Genet. 1989, 45 (3): 381–7. PMC 1683406 . PMID 2773933.  引文格式1维护：显式使用等标签 (link)
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• Oppenheim FG, Yang YC, Diamond RD; et al. The primary structure and functional characterization of the neutral histidine-rich polypeptide from human parotid secretion.. J. Biol. Chem. 1986, 261 (3): 1177–82. PMID 3944083.  引文格式1维护：显式使用等标签 (link)
• Sabatini LM, Ota T, Azen EA. Nucleotide sequence analysis of the human salivary protein genes HIS1 and HIS2, and evolution of the STATH/HIS gene family.. Mol. Biol. Evol. 1993, 10 (3): 497–511. PMID 8336540. 
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• Iontcheva I, Oppenheim FG, Offner GD, Troxler RF. Molecular mapping of statherin- and histatin-binding domains in human salivary mucin MG1 (MUC5B) by the yeast two-hybrid system.. J. Dent. Res. 2000, 79 (2): 732–9. PMID 10728974. doi:10.1177/00220345000790020601. 
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• Tamaki N, Tada T, Morita M, Watanabe T. Comparison of inhibitory activity on calcium phosphate precipitation by acidic proline-rich proteins, statherin, and histatin-1.. Calcif. Tissue Int. 2003, 71 (1): 59–62. PMID 12060866. doi:10.1007/s00223-001-1084-0. 
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• Yin A, Margolis HC, Grogan J; et al. Physical parameters of hydroxyapatite adsorption and effect on candidacidal activity of histatins.. Arch. Oral Biol. 2003, 48 (5): 361–8. PMID 12711380. doi:10.1016/S0003-9969(03)00012-8.  引文格式1维护：显式使用等标签 (link)
• Michels AA, Nguyen VT, Fraldi A; et al. MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner.. Mol. Cell. Biol. 2003, 23 (14): 4859–69. PMC 162212 . PMID 12832472. doi:10.1128/MCB.23.14.4859-4869.2003.  引文格式1维护：显式使用等标签 (link)
• Gerhard DS, Wagner L, Feingold EA; et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.  引文格式1维护：显式使用等标签 (link)
• Bruno LS, Li X, Wang L; et al. Two-hybrid analysis of human salivary mucin MUC7 interactions.. Biochim. Biophys. Acta. 2005, 1746 (1): 65–72. PMID 16203048. doi:10.1016/j.bbamcr.2005.08.007.  引文格式1维护：显式使用等标签 (link)
• Cabras T, Fanali C, Monteiro JA; et al. Tyrosine polysulfation of human salivary histatin 1. A post-translational modification specific of the submandibular gland.. J. Proteome Res. 2007, 6 (7): 2472–80. PMID 17503797. doi:10.1021/pr0700706.  引文格式1维护：显式使用等标签 (link)