PER2

PER2
已知的结构
PDB	直系同源搜索：PDBe RCSB
PDBID列表
	3GDI、4CT0、4U8H
标识符
代号	PER2
扩展标识	OMIM：603426；MGI：1195265；HomoloGene：7885；GeneCards：PER2；OMA：PER2 - orthologs
基因位置（人类）
染色体	2號染色體
终止	238,290,102 bp
基因位置（小鼠）
染色体	小鼠1号染色体
终止	91,387,046 bp
RNA表达模式
	Top expressed in
	mucosa of paranasal sinus; ; bronchial epithelial cell; ; palpebral conjunctiva; ; nasal epithelium; ; tail of epididymis; ; caput epididymis; ; skin of thigh;
	Top expressed in
	left lung lobe; ; lobe of cerebellum;
	查阅更多表达数据
	; ;
	查阅更多表达数据
基因本體
分子功能	转录共激活因子活性; transcription cis-regulatory region binding; 血浆蛋白结合; transcription corepressor binding; 转录因子结合;
細胞組分	核仁; 细胞质的核周区域; 细胞核; 細胞質;
生物學過程	histone H3 deacetylation; 糖异生; regulation of transcription, DNA-templated; regulation of insulin secretion; rhythmic process; negative regulation of fat cell proliferation; negative regulation of circadian rhythm; negative regulation of transcription by RNA polymerase II; circadian regulation of gene expression; transcription, DNA-templated; 脂肪酸代謝; regulation of cell cycle; negative regulation of protein ubiquitination; circadian regulation of translation; response to ischemia; regulation of vasoconstriction; glycogen biosynthetic process; negative regulation of transcription regulatory region DNA binding; regulation of circadian rhythm; 昼夜节律; white fat cell differentiation; regulation of glutamate uptake involved in transmission of nerve impulse; lactate biosynthetic process; negative regulation of transcription, DNA-templated; regulation of neurogenesis; positive regulation of nucleic acid-templated transcription; response to light stimulus; entrainment of circadian clock by photoperiod; positive regulation of cold-induced thermogenesis;
	来源：Amigo / QuickGO
直系同源
	8864
	18627
	ENSG00000132326
	ENSMUSG00000055866
	O15055
	O54943
	NM_003894; NM_022817
	NM_011066
	NP_073728
	NP_035196
	维基数据
檢視/編輯人類	檢視/編輯小鼠

PER2是由人类基因per2 编码的蛋白质，与昼夜节律有关^[5]^[6]，是黑腹果蝇 Period 基因在哺乳动物基因组中的同源物^[7]。

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000132326 – Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000055866 – Ensembl, 2017年5月
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Shearman LP, Zylka MJ, Weaver DR, Kolakowski LF, Reppert SM. Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei. Neuron. Dec 1997, 19 (6): 1261–9. PMID 9427249. S2CID 10059149. doi:10.1016/S0896-6273(00)80417-1 .
^ Xu Y, Toh KL, Jones CR, Shin JY, Fu YH, Ptácek LJ. Modeling of a human circadian mutation yields insights into clock regulation by PER2. Cell. Jan 2007, 128 (1): 59–70. PMC 1828903 . PMID 17218255. doi:10.1016/j.cell.2006.11.043.
^ Shearman LP, Zylka MJ, Weaver DR, Kolakowski LF, Reppert SM. Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei. Neuron. Dec 1997, 19 (6): 1261–1269. PMID 9427249. S2CID 10059149. doi:10.1016/s0896-6273(00)80417-1 .

外部链接

醫學主題詞表（MeSH）：PER2+protein,+human
PDB中UniProt可用的所有結構信息之概述：O15055 (Human Period circadian protein homolog 2) 在PDBe-KB（英语：PDBe-KB）。
PDB中UniProt可用的所有結構信息之概述：O54943 (Mouse Period circadian protein homolog 2) 在PDBe-KB（英语：PDBe-KB）。

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000132326 – Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000055866 – Ensembl, 2017年5月

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9427249-5] Shearman LP, Zylka MJ, Weaver DR, Kolakowski LF, Reppert SM. Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei. Neuron. Dec 1997, 19 (6): 1261–9. PMID 9427249. S2CID 10059149. doi:10.1016/S0896-6273(00)80417-1 .

[pmid17218255-6] Xu Y, Toh KL, Jones CR, Shin JY, Fu YH, Ptácek LJ. Modeling of a human circadian mutation yields insights into clock regulation by PER2. Cell. Jan 2007, 128 (1): 59–70. PMC 1828903 . PMID 17218255. doi:10.1016/j.cell.2006.11.043.

[7] Shearman LP, Zylka MJ, Weaver DR, Kolakowski LF, Reppert SM. Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei. Neuron. Dec 1997, 19 (6): 1261–1269. PMID 9427249. S2CID 10059149. doi:10.1016/s0896-6273(00)80417-1 .

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