CXCL10

CXCL10
已知的结构
PDB	直系同源搜索：PDBe RCSB
PDBID列表
	1O80、1LV9、1O7Y、1O7Z
标识符
代号	CXCL10
扩展标识	OMIM：147310；MGI：1352450；HomoloGene：1203；GeneCards：CXCL10；OMA：CXCL10 - orthologs
基因位置（人类）
染色体	4号染色体
终止	76,023,497 bp
基因位置（小鼠）
染色体	小鼠5号染色体
终止	92,496,748 bp
RNA表达模式
	Top expressed in
	olfactory zone of nasal mucosa; ; epithelium of nasopharynx;
	Top expressed in
	right kidney; ; subcutaneous adipose tissue;
	查阅更多表达数据
	查阅更多表达数据
基因本体
分子功能	细胞因子活性; heparin binding; CXCR3 chemokine receptor binding; chemokine activity; 血浆蛋白结合; cAMP-dependent protein kinase regulator activity; signaling receptor binding; chemoattractant activity;
细胞组分	细胞外区域; external side of plasma membrane; 细胞外空间; 胞内;
生物学过程	regulation of endothelial tube morphogenesis; negative regulation of myoblast differentiation; cellular response to heat; response to vitamin D; positive regulation of cell migration; T cell chemotaxis; chemokine-mediated signaling pathway; cell-cell signaling; response to virus; muscle organ development; positive regulation of monocyte chemotaxis; positive regulation of release of sequestered calcium ion into cytosol; endothelial cell activation; positive regulation of cAMP-mediated signaling; regulation of T cell chemotaxis; blood circulation; 趋化性; positive regulation of leukocyte chemotaxis; cell surface receptor signaling pathway; response to lipopolysaccharide; negative regulation of myoblast fusion; defense response to virus; regulation of cell population proliferation; 免疫反应; positive regulation of cell population proliferation; response to auditory stimulus; negative regulation of angiogenesis; response to cold; cellular response to lipopolysaccharide; response to gamma radiation; positive regulation of T cell migration; 讯息传递; positive regulation of transcription by RNA polymerase II; regulation of protein kinase activity; defense response; inflammatory response; antimicrobial humoral immune response mediated by antimicrobial peptide; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway; cytokine-mediated signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; response to bacterium; neutrophil chemotaxis; leukocyte chemotaxis; positive chemotaxis; regulation of apoptotic process;
	来源：Amigo / QuickGO
直系同源
	3627
	15945
	ENSG00000169245
	ENSMUSG00000034855
	P02778
	P17515
	NM_001565
	NM_021274
	NP_001556
	NP_067249
	维基数据
查看/编辑人类	查看/编辑小鼠

CXCL10（英语：C-X-C motif chemokine 10）是一小分子的细胞因子属于CXC趋化因子家族^[5]，又被称作“干扰素伽玛诱导的10千道尔顿蛋白”（10 kDa interferon-gamma-induced protein，IP-10）^[6]化学式为：C₃₇₅H₆₅₂O₁₀₈N₁₁₄S₅^[7]。干扰素伽玛可以在多种细胞（如巨噬细胞^[8]，单核细胞^[8]，内皮细胞^[9]和成纤维细胞）中诱导CXCL10的表达。CXCL10的功能包括对T细胞和单核细胞的细胞趋化作用^[10]^[11]，促进T细胞黏附于内皮细胞^[9]，抗肿瘤^[12]，及血管新生^[9]。人类的CXCL10基因与CXCL9，CXCL11的基因相邻聚集在第四染色体上。CXCL10, CXCL9和CXCL11结合趋化因子受体 CXCR3而起其细胞趋化作用^[10]^[11]。

参见

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000169245 – Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000034855 – Ensembl, 2017年5月
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Liu L, Callahan MK, Huang D, Ransohoff RM. Chemokine receptor CXCR3: an unexpected enigma. Curr Top Dev Biol. 2005;68:149-81.
^ Kaplan G, Luster AD, Hancock G, Cohn ZA. The expression of a gamma interferon-induced protein (IP-10) in delayed immune responses in human skin. J Exp Med. 1987 Oct 1;166(4):1098-108.
^ Expasy - ProtParam. web.expasy.org. [2026-02-10].
^ ^8.0 ^8.1 Narumi S, Hamilton TA. Inducible expression of murine IP-10 mRNA varies with the state of macrophage inflammatory activity. J Immunol. 1991 May 1;146(9):3038-44.
^ ^9.0 ^9.1 ^9.2 Angiolillo AL, Sgadari C, Taub DD, Liao F, Farber JM, Maheshwari S, Kleinman HK, Reaman GH, Tosato G. Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo. J Exp Med. 1995 Jul 1;182(1):155-62.
^ ^10.0 ^10.1 Loetscher M, Gerber B, Loetscher P, Jones SA, Piali L, Clark-Lewis I, Baggiolini M, Moser B. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. J Exp Med. 1996 Sep 1;184(3):963-9.
^ ^11.0 ^11.1 Weng Y, Siciliano SJ, Waldburger KE, Sirotina-Meisher A, Staruch MJ, Daugherty BL, Gould SL, Springer MS, DeMartino JA. Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors. J Biol Chem. 1998 Jul 17;273(29):18288-91.
^ Luster AD, Leder P. IP-10, a -C-X-C- chemokine, elicits a potent thymus-dependent antitumor response in vivo. J Exp Med. 1993 Sep 1;178(3):1057-65

外部链接

Charo IF, Ransohoff RM. The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med. 2006 Feb 9;354(6):610-21.（页面存档备份，存于互联网档案馆）

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000169245 – Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000034855 – Ensembl, 2017年5月

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Liu L, Callahan MK, Huang D, Ransohoff RM. Chemokine receptor CXCR3: an unexpected enigma. Curr Top Dev Biol. 2005;68:149-81.

[6] Kaplan G, Luster AD, Hancock G, Cohn ZA. The expression of a gamma interferon-induced protein (IP-10) in delayed immune responses in human skin. J Exp Med. 1987 Oct 1;166(4):1098-108.

[7] Expasy - ProtParam. web.expasy.org. [2026-02-10].

[nor-8] 8.0 ^8.1 Narumi S, Hamilton TA. Inducible expression of murine IP-10 mRNA varies with the state of macrophage inflammatory activity. J Immunol. 1991 May 1;146(9):3038-44.

[ang-9] 9.0 ^9.1 ^9.2 Angiolillo AL, Sgadari C, Taub DD, Liao F, Farber JM, Maheshwari S, Kleinman HK, Reaman GH, Tosato G. Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo. J Exp Med. 1995 Jul 1;182(1):155-62.

[chemo-10] 10.0 ^10.1 Loetscher M, Gerber B, Loetscher P, Jones SA, Piali L, Clark-Lewis I, Baggiolini M, Moser B. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. J Exp Med. 1996 Sep 1;184(3):963-9.

[fun-11] 11.0 ^11.1 Weng Y, Siciliano SJ, Waldburger KE, Sirotina-Meisher A, Staruch MJ, Daugherty BL, Gould SL, Springer MS, DeMartino JA. Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors. J Biol Chem. 1998 Jul 17;273(29):18288-91.

[12] Luster AD, Leder P. IP-10, a -C-X-C- chemokine, elicits a potent thymus-dependent antitumor response in vivo. J Exp Med. 1993 Sep 1;178(3):1057-65

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