TRAF7

TRAF7
标识符
代号	TRAF7
扩展标识	OMIM：606692；MGI：3042141；HomoloGene：12998；GeneCards：TRAF7；OMA：TRAF7 - orthologs
基因位置（人类）
染色体	16号染色体
终止	2,178,129 bp
基因位置（小鼠）
染色体	小鼠17号染色体
终止	24,746,912 bp
RNA表达模式
	Top expressed in
	stromal cell of endometrium; ; pancreatic ductal cell; ; ganglionic eminence; ; skin of leg; ; skin of abdomen; ; mucosa of transverse colon; ; left uterine tube; ; muscle layer of sigmoid colon; ; body of stomach;
	Top expressed in
	ventricular zone; ; neural layer of retina; ; tail of embryo;
	查阅更多表达数据
	无数据
基因本体
分子功能	锌离子结合; 血浆蛋白结合; 金属离子结合; 转移酶活性; 泛素蛋白转移酶活性;
细胞组分	ubiquitin ligase complex; 细胞膜; 细胞内膜结合细胞器; cytoplasmic vesicle; 核仁;
生物学过程	细胞凋亡; positive regulation of apoptotic signaling pathway; regulation of transcription, DNA-templated; protein ubiquitination; transcription, DNA-templated; positive regulation of MAPK cascade; ribosomal large subunit assembly; Notch信号通路; regulation of ERK1 and ERK2 cascade;
	来源：Amigo / QuickGO
直系同源
	84231
	224619
	ENSG00000131653
	ENSMUSG00000052752
	Q6Q0C0
	Q922B6
	NM_032271; NM_206835
	NM_001172113; NM_001172114; NM_153792
	NP_115647
	无数据
	维基数据
查看/编辑人类	查看/编辑小鼠

TRAF7（“TNF受体相关因子7”，TNF receptor associated factor 7，也称为“环指和WD重复结构域1”，ring finger and WD repeat domain 1，缩写“RFWD3”）是人类基因 TRAF7 编码的蛋白质，属于一种TNF受体相关因子（TRAF）^[5]。

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000131653 – Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000052752 – Ensembl, 2017年5月
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zotti, T; Uva, A; Ferravante, A; Vessichelli, M; Scudiero, I; Ceccarelli, M; Vito, P; Stilo, R. TRAF7 protein promotes Lys-29-linked polyubiquitination of IkappaB kinase (IKKgamma)/NF-kappaB essential modulator (NEMO) and p65/RelA protein and represses NF-kappaB activation.. The Journal of biological chemistry. 2011-07-01, 286 (26): 22924–33. PMID 21518757. doi:10.1074/jbc.M110.215426.

外部链接

医学主题词表（MeSH）：TRAF7

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000131653 – Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000052752 – Ensembl, 2017年5月

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid21518757-5] Zotti, T; Uva, A; Ferravante, A; Vessichelli, M; Scudiero, I; Ceccarelli, M; Vito, P; Stilo, R. TRAF7 protein promotes Lys-29-linked polyubiquitination of IkappaB kinase (IKKgamma)/NF-kappaB essential modulator (NEMO) and p65/RelA protein and represses NF-kappaB activation.. The Journal of biological chemistry. 2011-07-01, 286 (26): 22924–33. PMID 21518757. doi:10.1074/jbc.M110.215426.

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