TRAF7

TRAF7
標識符
代號	TRAF7
擴展標識	OMIM：606692；MGI：3042141；HomoloGene：12998；GeneCards：TRAF7；OMA：TRAF7 - orthologs
基因位置（人類）
染色體	16號染色體
終止	2,178,129 bp
基因位置（小鼠）
染色體	小鼠17號染色體
終止	24,746,912 bp
RNA表現模式
	Top expressed in
	stromal cell of endometrium; ; pancreatic ductal cell; ; ganglionic eminence; ; skin of leg; ; skin of abdomen; ; mucosa of transverse colon; ; left uterine tube; ; muscle layer of sigmoid colon; ; body of stomach;
	Top expressed in
	ventricular zone; ; neural layer of retina; ; tail of embryo;
	查閱更多表現資料
	無資料
基因本體
分子功能	鋅離子結合; 血漿蛋白結合; 金屬離子結合; 轉移酶活性; 泛素蛋白轉移酶活性;
細胞組分	ubiquitin ligase complex; 細胞膜; 細胞內膜結合胞器; cytoplasmic vesicle; 核仁;
生物學過程	細胞凋亡; positive regulation of apoptotic signaling pathway; regulation of transcription, DNA-templated; protein ubiquitination; transcription, DNA-templated; positive regulation of MAPK cascade; ribosomal large subunit assembly; Notch信號通路; regulation of ERK1 and ERK2 cascade;
	來源：Amigo / QuickGO
直系同源
	84231
	224619
	ENSG00000131653
	ENSMUSG00000052752
	Q6Q0C0
	Q922B6
	NM_032271; NM_206835
	NM_001172113; NM_001172114; NM_153792
	NP_115647
	無資料
	維基數據
檢視/編輯人類	檢視/編輯小鼠

TRAF7（「TNF受體相關因子7」，TNF receptor associated factor 7，也稱為「環指和WD重複結構域1」，ring finger and WD repeat domain 1，縮寫「RFWD3」）是人類基因 TRAF7 編碼的蛋白質，屬於一種TNF受體相關因子（TRAF）^[5]。

參考文獻

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000131653 – Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000052752 – Ensembl, 2017年5月
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zotti, T; Uva, A; Ferravante, A; Vessichelli, M; Scudiero, I; Ceccarelli, M; Vito, P; Stilo, R. TRAF7 protein promotes Lys-29-linked polyubiquitination of IkappaB kinase (IKKgamma)/NF-kappaB essential modulator (NEMO) and p65/RelA protein and represses NF-kappaB activation.. The Journal of biological chemistry. 2011-07-01, 286 (26): 22924–33. PMID 21518757. doi:10.1074/jbc.M110.215426.

外部連結

醫學主題詞表（MeSH）：TRAF7

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000131653 – Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000052752 – Ensembl, 2017年5月

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid21518757-5] Zotti, T; Uva, A; Ferravante, A; Vessichelli, M; Scudiero, I; Ceccarelli, M; Vito, P; Stilo, R. TRAF7 protein promotes Lys-29-linked polyubiquitination of IkappaB kinase (IKKgamma)/NF-kappaB essential modulator (NEMO) and p65/RelA protein and represses NF-kappaB activation.. The Journal of biological chemistry. 2011-07-01, 286 (26): 22924–33. PMID 21518757. doi:10.1074/jbc.M110.215426.

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