α-SMA

Α-平滑肌
標識符
代號	ACTA2
擴展標識	OMIM：102620；MGI：87909；HomoloGene：133938；GeneCards：ACTA2；OMA：ACTA2 - orthologs
基因位置（人類）
染色體	10號染色體
終止	88,991,339 bp
基因位置（小鼠）
染色體	小鼠19號染色體
終止	34,232,990 bp
RNA表達模式
	Top expressed in
	saphenous vein; ; tail of epididymis; ; tibial arteries; ; body of uterus; ; Descending thoracic aorta;
	Top expressed in
	tunica media of zone of aorta; ; migratory enteric neural crest cell;
	查閱更多表達數據
	查閱更多表達數據
基因本體
分子功能	ATP結合; 核苷酸結合; protein kinase binding;
細胞組分	細胞質基質; 細胞質; actin cytoskeleton; smooth muscle contractile fiber; cell body; 板狀偽足; 絲狀偽足; 細胞骨架; 外排體; 細胞外空間; 大分子複合體;
生物學過程	肌肉收縮; 血壓調節; vascular associated smooth muscle contraction; mesenchyme migration; positive regulation of gene expression; glomerular mesangial cell development; response to virus; positive regulation of transcription, DNA-templated;
	來源：Amigo / QuickGO
直系同源
	59
	11475
	ENSG00000107796
	ENSMUSG00000035783
	P62736
	P62737
	NM_001141945; NM_001613; NM_001320855
	NM_007392
	NP_001135417; NP_001307784; NP_001604
	NP_031418
	維基數據
檢視/編輯人類	檢視/編輯小鼠

α-SMA（alpha smooth muscle actin，α平滑肌肌動蛋白，也稱為「主動脈平滑肌肌動蛋白」，aortic smooth muscle actin，「α肌動蛋白2」，alpha-actin-2，縮寫ACTA2）是一種細胞骨架蛋白，由人類基因 ACTA2 編碼，組成微絲，與平滑肌的肌肉收縮相關，在所有哺乳動物中高度保守^[5]。化學式為：C₁₈₅₅H₂₉₀₃O₅₆₆N₄₉₃S₂₁^[6]

參考文獻

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000107796 – Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000035783 – Ensembl, 2017年5月
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ueyama H, Bruns G, Kanda N. Assignment of the vascular smooth muscle actin gene ACTSA to human chromosome 10. Jinrui Idengaku Zasshi. The Japanese Journal of Human Genetics. June 1990, 35 (2): 145–50. PMID 2398629. doi:10.1007/BF01876459 .
^ Expasy - ProtParam. web.expasy.org. [2025-06-30].

外部連結

GeneReviews/NIH/NCBI/UW entry on Thoracic Aortic Aneurysms and Aortic Dissections （頁面存檔備份，存於互聯網檔案館）
Human ACTA2 genome location and ACTA2 gene details page in the UCSC Genome Browser（英語：UCSC Genome Browser）.

這是一篇分子與細胞生物學（分子細胞生物學）小作品。您可以透過編輯或修訂擴充其內容。

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000107796 – Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000035783 – Ensembl, 2017年5月

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2398629-5] Ueyama H, Bruns G, Kanda N. Assignment of the vascular smooth muscle actin gene ACTSA to human chromosome 10. Jinrui Idengaku Zasshi. The Japanese Journal of Human Genetics. June 1990, 35 (2): 145–50. PMID 2398629. doi:10.1007/BF01876459 .

[6] Expasy - ProtParam. web.expasy.org. [2025-06-30].

[1]

[2]

[3]

[4]

[5]

[6]