SIRT1

SIRT1
已知的结构 PDB 直系同源搜索：PDBe RCSB PDBID列表 4I5I、4IF6、4IG9、4KXQ、4ZZH、4ZZI、4ZZJ、5BTR
标识符
代号	SIRT1
扩展标识	OMIM：604479；MGI：2135607；HomoloGene：56556；GeneCards：SIRT1；OMA：SIRT1 - orthologs
基因位置（人类） 染色体 10号染色体 基因座 10q21.3 起始 67,884,656 bp 终止 67,918,390 bp
基因位置（小鼠） 染色体 小鼠10号染色体 基因座 10|10 B4 起始 63,154,784 bp 终止 63,217,483 bp
RNA表达模式 Bgee 人类 小鼠（直系同源） Top expressed in ganglionic eminence ventricular zone right adrenal cortex left adrenal cortex Top expressed in tail of embryo cumulus cell 查阅更多表达数据 BioGPS 查阅更多表达数据
基因本体 分子功能 transcription corepressor activity protein domain specific binding core promoter sequence-specific DNA binding protein C-terminus binding keratin filament binding 转录因子结合 金属离子结合 HLH domain binding 酶结合 protein deacetylase activity histone binding 血浆蛋白结合 NAD-dependent histone deacetylase activity NAD-dependent protein deacetylase activity histone deacetylase activity p53 binding mitogen-activated protein kinase binding deacetylase activity bHLH transcription factor binding NAD+ binding 相同蛋白质结合 NAD+ ADP-ribosyltransferase activity 水解酶活性 NAD-dependent histone deacetylase activity (H3-K9 specific) DNA-binding transcription activator activity, RNA polymerase II-specific 细胞组分 细胞质 nuclear envelope rDNA heterochromatin chromatin silencing complex 线粒体 细胞核 ESC/E(Z) complex 核仁 染色质 核质 PML body 内膜 细胞质基质 生物学过程 cellular triglyceride homeostasis positive regulation of MHC class II biosynthetic process DNA synthesis involved in DNA repair positive regulation of protein phosphorylation positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway rhythmic process single strand break repair muscle organ development histone H3-K9 deacetylation negative regulation of cellular response to testosterone stimulus regulation of peroxisome proliferator activated receptor signaling pathway cellular response to DNA damage stimulus regulation of bile acid biosynthetic process 脱氧核糖核酸复制 negative regulation of TOR signaling positive regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of glucose metabolic process rDNA heterochromatin assembly negative regulation of DNA damage response, signal transduction by p53 class mediator DNA methylation-dependent heterochromatin assembly 昼夜节律 positive regulation of cellular senescence 精子发生 intrinsic apoptotic signaling pathway in response to DNA damage cellular response to ionizing radiation negative regulation of helicase activity cholesterol homeostasis response to leptin cellular response to hypoxia triglyceride mobilization negative regulation of prostaglandin biosynthetic process proteasome-mediated ubiquitin-dependent protein catabolic process 细胞凋亡 peptidyl-lysine deacetylation negative regulation of fat cell differentiation negative regulation of peptidyl-lysine acetylation regulation of transcription, DNA-templated positive regulation of adaptive immune response stress-induced premature senescence negative regulation of androgen receptor signaling pathway negative regulation of transforming growth factor beta receptor signaling pathway response to oxidative stress negative regulation of DNA-binding transcription factor activity negative regulation of gene expression transcription, DNA-templated negative regulation of cAMP-dependent protein kinase activity pyrimidine dimer repair by nucleotide-excision repair response to insulin histone H3-K9 modification positive regulation of macroautophagy positive regulation of cholesterol efflux protein ubiquitination negative regulation of cell growth positive regulation of macrophage apoptotic process rRNA processing regulation of brown fat cell differentiation negative regulation of phosphorylation viral process DNA修复 negative regulation of neuron death positive regulation of histone H3-K9 methylation negative regulation of histone H3-K14 acetylation negative regulation of protein kinase B signaling 细胞分化 ovulation from ovarian follicle regulation of protein serine/threonine kinase activity negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator protein ADP-ribosylation leptin-mediated signaling pathway negative regulation of apoptotic process negative regulation of transcription by RNA polymerase II chromatin organization negative regulation of I-kappaB kinase/NF-kappaB signaling circadian regulation of gene expression protein deacetylation fatty acid homeostasis protein destabilization regulation of mitotic cell cycle positive regulation of cAMP-dependent protein kinase activity white fat cell differentiation positive regulation of insulin receptor signaling pathway negative regulation of transcription, DNA-templated negative regulation of NF-kappaB transcription factor activity peptidyl-lysine acetylation response to hydrogen peroxide intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator negative regulation of histone H4-K16 acetylation positive regulation of endothelial cell proliferation regulation of smooth muscle cell apoptotic process behavioral response to starvation cellular glucose homeostasis cellular response to starvation cellular response to tumor necrosis factor positive regulation of DNA repair multicellular organism development regulation of cell population proliferation positive regulation of cell population proliferation regulation of endodeoxyribonuclease activity regulation of cellular response to heat positive regulation of phosphatidylinositol 3-kinase signaling negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway UV-damage excision repair histone deacetylation positive regulation of transcription by RNA polymerase II 血管新生 macrophage cytokine production regulation of lipid storage positive regulation of adipose tissue development macrophage differentiation transcription by RNA polymerase II positive regulation of smooth muscle cell differentiation negative regulation of histone H3-K9 trimethylation positive regulation of apoptotic process cellular response to hydrogen peroxide histone H3 deacetylation negative regulation of protein acetylation regulation of apoptotic process cellular response to leukemia inhibitory factor positive regulation of angiogenesis transforming growth factor beta receptor signaling pathway positive regulation of blood vessel endothelial cell migration negative regulation of cellular senescence 来源：Amigo / QuickGO
直系同源 物种 人类 小鼠 Entrez 23411 93759 Ensembl ENSG00000096717 ENSMUSG00000020063 UniProt Q96EB6 Q923E4 mRNA序列 NM_001142498 ​NM_001314049 ​NM_012238 NM_001159589 ​NM_001159590 ​NM_019812 蛋白序列 NP_001135970 ​NP_001300978 ​NP_036370 NP_001153061 ​NP_062786 基因位置 Chr 10：67.88 – 67.92 Mb Chr 10：63.15 – 63.22 Mb PubMed查询
维基数据
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SIRT1（英语：Sirtuin 1），也被称为 NAD-依赖性去乙酰化酶Sirtuin-1（英语：NAD-dependent deacetylase sirtuin-1），是人类基因组中由SIRT1基因编码的蛋白。人的SIRT1基因位于10号染色体上。SIRT1的功能是去除蛋白质上的乙酰基团（去乙酰化）。SIRT1的去乙酰化功能在一些生物学过程中有发挥一定的作用。

外部链接

• Corante weblog by Derek Lowe about sir2 and SIRT1 research.