TLR2

TLR2
已知的结构 PDB 直系同源搜索：PDBe RCSB PDBID列表 1FYW、1FYX、1O77、2Z7X、2Z80
标识符
代号	TLR2
扩展标识	OMIM：603028；MGI：1346060；HomoloGene：20695；GeneCards：TLR2；OMA：TLR2 - orthologs
基因位置（人类） 染色体 4號染色體 基因座 4q31.3 起始 153,684,070 bp 终止 153,706,260 bp
基因位置（小鼠） 染色体 小鼠3号染色体 基因座 3|3 E3 起始 83,743,579 bp 终止 83,749,074 bp
RNA表达模式 Bgee 人类 小鼠（直系同源） Top expressed in right lung upper lobe of left lung cartilage tissue Top expressed in stroma of bone marrow right lung lobe tibiofemoral joint conjunctival fornix epithelium of lens vestibular membrane of cochlear duct 查阅更多表达数据 BioGPS 查阅更多表达数据
基因本體 分子功能 pattern recognition receptor activity lipopolysaccharide binding Toll-like receptor binding triacyl lipopeptide binding 血浆蛋白结合 peptidoglycan binding protein heterodimerization activity lipopolysaccharide immune receptor activity transmembrane signaling receptor activity lipopeptide binding 細胞組分 細胞質 integral component of membrane phagocytic vesicle membrane 高尔基体 膜 intrinsic component of plasma membrane 细胞膜 Toll-like receptor 1-Toll-like receptor 2 protein complex integral component of plasma membrane 脂筏模型 cytoplasmic vesicle cell projection cell surface cell body 生物學過程 interleukin-10 production positive regulation of interferon-beta production defense response to Gram-positive bacterium positive regulation of interleukin-18 production positive regulation of toll-like receptor signaling pathway toll-like receptor TLR1:TLR2 signaling pathway positive regulation of inflammatory response cellular response to bacterial lipopeptide positive regulation of interleukin-12 production immune system process detection of diacyl bacterial lipopeptide cellular response to diacyl bacterial lipopeptide I-kappaB phosphorylation positive regulation of nitric-oxide synthase biosynthetic process MyD88-dependent toll-like receptor signaling pathway cellular response to triacyl bacterial lipopeptide detection of triacyl bacterial lipopeptide positive regulation of Wnt signaling pathway positive regulation of gene expression cellular response to lipoteichoic acid positive regulation of NF-kappaB transcription factor activity 免疫反应 positive regulation of interleukin-8 production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production positive regulation of chemokine production 先天免疫系統 inflammatory response toll-like receptor TLR6:TLR2 signaling pathway response to molecule of bacterial origin 訊息傳遞 positive regulation of transcription by RNA polymerase II 细胞凋亡 response to lipopolysaccharide response to progesterone toll-like receptor signaling pathway response to insulin central nervous system myelin formation nitric oxide metabolic process response to fatty acid leukotriene metabolic process toll-like receptor 2 signaling pathway positive regulation of oligodendrocyte differentiation response to bacterial lipoprotein negative regulation of cell population proliferation response to toxic substance response to hypoxia positive regulation of interleukin-10 production lipopolysaccharide-mediated signaling pathway microglial cell activation 来源：Amigo / QuickGO
直系同源 物種 人類 小鼠 Entrez 7097 24088 Ensembl ENSG00000137462 ENSMUSG00000027995 UniProt O60603 Q9QUN7 mRNA序列 ​NM_003264 ​NM_001318787 ​NM_001318789 ​NM_001318790 ​NM_001318791 ​NM_001318793 ​NM_001318795 ​NM_001318796 NM_011905 蛋白序列 NP_001305716 ​NP_001305718 ​NP_001305719 ​NP_001305720 ​NP_001305722 ​NP_001305724 ​NP_001305725 ​NP_003255 NP_036035 基因位置 Chr 4：153.68 – 153.71 Mb Chr 3：83.74 – 83.75 Mb PubMed查询
维基数据
檢視/編輯人類 檢視/編輯小鼠

Toll样受体2（英語：Toll-like receptor 2）是由人类基因 TLR2 编码的蛋白质，是一种膜蛋白质和受体，也被称为CD282（分化簇282，cluster of differentiation 282），是Toll样受体（TLR）家族的成员，在免疫系统中起到重要作用。

延伸阅读

• Aderem A, Ulevitch RJ. Toll-like receptors in the induction of the innate immune response. Nature. August 2000, 406 (6797): 782–7. PMID 10963608. S2CID 4410405. doi:10.1038/35021228. 
• Ey B, Eyking A, Klepak M, Salzman NH, Göthert JR, Rünzi M, Schmid KW, Gerken G, Podolsky DK, Cario E. Loss of TLR2 worsens spontaneous colitis in MDR1A deficiency through commensally induced pyroptosis. J. Immunol. June 2013, 190 (11): 5676–88. PMC 3659955 . PMID 23636052. doi:10.4049/jimmunol.1201592. 
• Muzio M, Polentarutti N, Bosisio D, Manoj Kumar PP, Mantovani A. Toll-like receptor family and signalling pathway. Biochemical Society Transactions. October 2000, 28 (5): 563–6. PMID 11044375. doi:10.1042/bst0280563. 
• Hallman M, Rämet M, Ezekowitz RA. Toll-like receptors as sensors of pathogens. Pediatric Research. September 2001, 50 (3): 315–21. PMID 11518816. S2CID 24420705. doi:10.1203/00006450-200109000-00004 . 
• Dziarski R, Gupta D. Role of MD-2 in TLR2- and TLR4-mediated recognition of Gram-negative and Gram-positive bacteria and activation of chemokine genes. Journal of Endotoxin Research. 2001, 6 (5): 401–5. PMID 11521063. doi:10.1177/09680519000060050101 . 
• Lien E, Ingalls RR. Toll-like receptors. Critical Care Medicine. January 2002, 30 (1 Suppl): S1–11. PMID 11782555. doi:10.1097/00003246-200201001-00001. 
• Xu D, Komai-Koma M, Liew FY. Expression and function of Toll-like receptor on T cells. Cellular Immunology. February 2005, 233 (2): 85–9. PMID 15950961. doi:10.1016/j.cellimm.2005.04.019. 
• Lorenz E. TLR2 and TLR4 expression during bacterial infections. Current Pharmaceutical Design. 2007, 12 (32): 4185–93. PMID 17100621. doi:10.2174/138161206778743547. 

外部链接

• 醫學主題詞表（MeSH）：TLR2+protein,+human