FOXP3

FOXP3
已知的结构 PDB 直系同源搜索：PDBe RCSB PDBID列表 3QRF、4WK8
标识符
代号	FOXP3
扩展标识	OMIM：300292；MGI：1891436；HomoloGene：8516；GeneCards：FOXP3；OMA：FOXP3 - orthologs
基因位置（人类） 染色体 X染色体 基因座 Xp11.23 起始 49,250,438 bp 终止 49,270,477 bp
基因位置（小鼠） 染色体 小鼠X染色体 基因座 X A1.1|X 3.41 cM 起始 7,439,883 bp 终止 7,461,484 bp
RNA表达模式 Bgee 人类 小鼠（直系同源） Top expressed in tendon of biceps brachii Top expressed in male urethra tail of embryo dentate gyrus of hippocampal formation granule cell neural layer of retina 查阅更多表达数据 BioGPS 查阅更多表达数据
基因本体 分子功能 sequence-specific DNA binding NF-kappaB binding transcription corepressor activity nucleic acid binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding 血浆蛋白结合 histone deacetylase binding DNA结合转录因子活性 NFAT protein binding histone acetyltransferase binding 金属离子结合 DNA结合 protein homodimerization activity DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding 细胞组分 细胞核 胞内 细胞质 核质 大分子复合体 生物学过程 negative regulation of cell population proliferation negative regulation of NF-kappaB transcription factor activity B cell homeostasis regulation of isotype switching to IgG isotypes myeloid cell homeostasis negative regulation of inflammatory response positive regulation of interleukin-4 production regulation of immunoglobulin production regulation of transcription by RNA polymerase II regulation of T cell anergy negative regulation of interleukin-6 production tolerance induction to self antigen regulation of transcription, DNA-templated negative regulation of DNA-binding transcription factor activity positive regulation of T cell tolerance induction negative regulation of immune response negative regulation of interferon-gamma production tolerance induction regulatory T cell differentiation positive regulation of transcription, DNA-templated negative regulation of interleukin-2 production positive regulation of histone acetylation negative regulation of interleukin-5 production negative regulation of chronic inflammatory response CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation positive regulation of transcription by RNA polymerase II negative regulation of activated T cell proliferation positive regulation of gene expression negative regulation of interleukin-4 production negative regulation of interleukin-10 production 肿瘤坏死因子产生的负调控 T cell homeostasis negative regulation of CREB transcription factor activity negative regulation of T-helper 17 cell differentiation T细胞激活 positive regulation of immature T cell proliferation in thymus positive regulation of regulatory T cell differentiation negative regulation of transcription by RNA polymerase II positive regulation of peripheral T cell tolerance induction positive regulation of transforming growth factor beta1 production negative regulation of transcription, DNA-templated negative regulation of lymphocyte proliferation negative regulation of histone acetylation negative regulation of interleukin-17 production response to virus negative regulation of histone deacetylation CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation negative regulation of T cell proliferation 染色体重建 cytokine production negative regulation of T cell cytokine production negative regulation of isotype switching to IgE isotypes T cell receptor signaling pathway positive regulation of T cell anergy transcription, DNA-templated T cell mediated immunity negative regulation of gene expression anatomical structure morphogenesis regulation of Wnt signaling pathway regulation of regulatory T cell differentiation 来源：Amigo / QuickGO
直系同源 物种 人类 小鼠 Entrez 50943 20371 Ensembl ENSG00000049768 ENSMUSG00000039521 UniProt Q9BZS1 Q99JB6 mRNA序列 NM_001114377 ​NM_014009 NM_001199347 ​NM_001199348 ​NM_054039 蛋白序列 NP_001107849 ​NP_054728 NP_001186276 ​NP_001186277 ​NP_473380 基因位置 Chr X：49.25 – 49.27 Mb Chr X：7.44 – 7.46 Mb PubMed查询
维基数据
查看/编辑人类 查看/编辑小鼠

FOXP3（Forkhead box protein P3）基因，即叉头框P3基因，也称为scurfin蛋白，位于X染色体，属于FOX蛋白家族，是一种与免疫系统响应有关的转录因子。

外部链接

• GeneReviews/NIH/NCBI/UW entry on IPEX Syndrome （页面存档备份，存于互联网档案馆）
• 医学主题词表（MeSH）：FOXP3+protein,+human