FOXP3

FOXP3
已知的結構 PDB 直系同源搜尋：PDBe RCSB PDBID列表 3QRF、4WK8
標識符
代號	FOXP3
擴展標識	OMIM：300292；MGI：1891436；HomoloGene：8516；GeneCards：FOXP3；OMA：FOXP3 - orthologs
基因位置（人類） 染色體 X染色體 基因座 Xp11.23 起始 49,250,438 bp 終止 49,270,477 bp
基因位置（小鼠） 染色體 小鼠X染色體 基因座 X A1.1|X 3.41 cM 起始 7,439,883 bp 終止 7,461,484 bp
RNA表達模式 Bgee 人類 小鼠（直系同源） Top expressed in tendon of biceps brachii Top expressed in male urethra tail of embryo dentate gyrus of hippocampal formation granule cell neural layer of retina 查閱更多表達數據 BioGPS 查閱更多表達數據
基因本體 分子功能 sequence-specific DNA binding NF-kappaB binding transcription corepressor activity nucleic acid binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding 血漿蛋白結合 histone deacetylase binding DNA結合轉錄因子活性 NFAT protein binding histone acetyltransferase binding 金屬離子結合 DNA結合 protein homodimerization activity DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding 細胞組分 細胞核 胞內 細胞質 核質 大分子複合體 生物學過程 negative regulation of cell population proliferation negative regulation of NF-kappaB transcription factor activity B cell homeostasis regulation of isotype switching to IgG isotypes myeloid cell homeostasis negative regulation of inflammatory response positive regulation of interleukin-4 production regulation of immunoglobulin production regulation of transcription by RNA polymerase II regulation of T cell anergy negative regulation of interleukin-6 production tolerance induction to self antigen regulation of transcription, DNA-templated negative regulation of DNA-binding transcription factor activity positive regulation of T cell tolerance induction negative regulation of immune response negative regulation of interferon-gamma production tolerance induction regulatory T cell differentiation positive regulation of transcription, DNA-templated negative regulation of interleukin-2 production positive regulation of histone acetylation negative regulation of interleukin-5 production negative regulation of chronic inflammatory response CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation positive regulation of transcription by RNA polymerase II negative regulation of activated T cell proliferation positive regulation of gene expression negative regulation of interleukin-4 production negative regulation of interleukin-10 production 腫瘤壞死因子產生的負調控 T cell homeostasis negative regulation of CREB transcription factor activity negative regulation of T-helper 17 cell differentiation T細胞活化 positive regulation of immature T cell proliferation in thymus positive regulation of regulatory T cell differentiation negative regulation of transcription by RNA polymerase II positive regulation of peripheral T cell tolerance induction positive regulation of transforming growth factor beta1 production negative regulation of transcription, DNA-templated negative regulation of lymphocyte proliferation negative regulation of histone acetylation negative regulation of interleukin-17 production response to virus negative regulation of histone deacetylation CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation negative regulation of T cell proliferation 染色體重建 cytokine production negative regulation of T cell cytokine production negative regulation of isotype switching to IgE isotypes T cell receptor signaling pathway positive regulation of T cell anergy transcription, DNA-templated T cell mediated immunity negative regulation of gene expression anatomical structure morphogenesis regulation of Wnt signaling pathway regulation of regulatory T cell differentiation 來源：Amigo / QuickGO
直系同源 物種 人類 小鼠 Entrez 50943 20371 Ensembl ENSG00000049768 ENSMUSG00000039521 UniProt Q9BZS1 Q99JB6 mRNA序列 NM_001114377 ​NM_014009 NM_001199347 ​NM_001199348 ​NM_054039 蛋白序列 NP_001107849 ​NP_054728 NP_001186276 ​NP_001186277 ​NP_473380 基因位置 Chr X：49.25 – 49.27 Mb Chr X：7.44 – 7.46 Mb PubMed查詢
維基數據
檢視/編輯人類 檢視/編輯小鼠

FOXP3（Forkhead box protein P3）基因，即叉頭框P3基因，也稱為scurfin蛋白，位於X染色體，屬於FOX蛋白家族，是一種與免疫系統響應有關的轉錄因子。

外部連結

• GeneReviews/NIH/NCBI/UW entry on IPEX Syndrome （頁面存檔備份，存於互聯網檔案館）
• 醫學主題詞表（MeSH）：FOXP3+protein,+human