RAD51

搜尋
結構	瑞士模型
域	蛋白質互聯

RAD51
RAD51
	Rad51結構圖。來源：PDB: 1SZP
標識符
符號	RAD51
其它／替代符號	RAD51A, RECA
美國國家生物技術資訊中心基因	5888
人類基因組組織基因命名委員會（英語：HUGO Gene Nomenclature Committee）	9817
人類孟德爾遺傳學在線	179617
蛋白質數據庫	1SZP
參考序列（英語：RefSeq）	NM_002875
通用蛋白質資源庫	Q06609
其它數據
基因座	15號 q15.1
結構
搜尋
結構	瑞士模型
域	蛋白質互聯

RAD51
已知的結構
PDB	直系同源搜尋：PDBe RCSB
PDBID列表
	1N0W、1B22
標識符
代號	RAD51
擴展標識	OMIM：179617；MGI：97890；HomoloGene：2155；GeneCards：RAD51；OMA：RAD51 - orthologs
基因位置（人類）
染色體	15號染色體
終止	40,732,340 bp
RNA表達模式
	Top expressed in
	buccal mucosa cell; ; ventricular zone; ; ganglionic eminence; ; left testis; ; right testis; ; mucosa of transverse colon;
	無數據
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	; ;
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基因本體
分子功能	核苷酸結合; DNA結合; ATP-dependent activity, acting on DNA; DNA strand exchange activity; DNA polymerase binding; protein C-terminus binding; 血漿蛋白結合; four-way junction DNA binding; 相同蛋白質結合; endodeoxyribonuclease activity; ATP結合; single-stranded DNA binding; double-stranded DNA binding; single-stranded DNA helicase activity; chromatin binding; 酶結合;
細胞組分	細胞質; site of double-strand break; PML body; 細胞骨架; 核質; 微管組織中心; nuclear chromosome; 線粒體基質; 核仁; 線粒體; 細胞質的核周區域; 染色質; 細胞核; 細胞質基質; 大分子複合體; condensed chromosome; condensed nuclear chromosome; lateral element; 染色體;
生物學過程	strand invasion; mitotic recombination-dependent replication fork processing; reciprocal meiotic recombination; DNA重組; regulation of double-strand break repair via homologous recombination; DNA代謝過程; positive regulation of DNA ligation; cellular response to camptothecin; double-strand break repair via homologous recombination; cellular response to ionizing radiation; mitotic recombination; protein homooligomerization; DNA修復; DNA unwinding involved in DNA replication; cellular response to DNA damage stimulus; interstrand cross-link repair; DNA recombinase assembly; negative regulation of G0 to G1 transition; telomere maintenance via recombination; telomere maintenance via telomere lengthening; replication fork processing; 減數分裂; chromosome organization involved in meiotic cell cycle;
	來源：Amigo / QuickGO
直系同源
	5888
	19361
	ENSG00000051180
	無數據
	Q06609
	Q08297
	NM_001164269; NM_001164270; NM_002875; NM_133487
	NM_011234
	NP_001157741; NP_001157742; NP_002866; NP_597994
	NP_035364
	維基數據
檢視/編輯人類	檢視/編輯小鼠

Rad51是真核生物體內的一種蛋白質，與原核生物的RecA 同源，是一種高度保守的蛋白，從酵母菌到人類之間的變異不大。人類的Rad51含有339個氨基酸，於同源重組中扮演主要角色，參與搜尋同源部位與DNA的配對過程。

人類的Rad51的基因位於第15號染色體。包括此基因在內，哺乳類共有七種類似recA的基因，包括Rad51、Rad51L1/B、Rad51L2/C、Rad51L3/D、XRCC2、XRCC3以及DMC1^[5]。

參考文獻

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000051180 – Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ [1] （頁面存檔備份，存於互聯網檔案館） Conway, A.B., Lynch, T.W., Zhang, Y., Fortin, G.S., Fung, C.W., Symington, L.S., Rice, P.A. Crystal structure of a Rad51 filament. Nat.Struct.Mol.Biol. v11 pp.791-796, 2004
^ Kawabata,M., Kawabata, T. and Nishibori, M. Role of recA/Rad51 family proteins in mammals. Acta Med.Okayama v59, No.1, pp.1-9(2005)

Galkin,V .E. et al. The Rad51/RadA N-Terminal domain activates nucleoprotein filament ATPase activity. Structure 14, pp. 983-992(2006)

Pellegrini, L. et al. Insights into DNA recombination from the structure of a Rad51-BRCA2 complex. Nature 420,287-293(2002)

外部連結

醫學主題詞表（MeSH）：RAD51+Protein

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000051180 – Ensembl, May 2017

[2] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] [1] （頁面存檔備份，存於互聯網檔案館） Conway, A.B., Lynch, T.W., Zhang, Y., Fortin, G.S., Fung, C.W., Symington, L.S., Rice, P.A. Crystal structure of a Rad51 filament. Nat.Struct.Mol.Biol. v11 pp.791-796, 2004

[5] Kawabata,M., Kawabata, T. and Nishibori, M. Role of recA/Rad51 family proteins in mammals. Acta Med.Okayama v59, No.1, pp.1-9(2005)

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