KLF4

KLF4
已知的结构 PDB 直系同源搜索：PDBe RCSB PDBID列表 2WBS、2WBU、4M9E
标识符
代号	KLF4
扩展标识	OMIM：602253；MGI：1342287；HomoloGene：3123；GeneCards：KLF4；OMA：KLF4 - orthologs
基因位置（人类） 染色体 9號染色體 基因座 9q31.2 起始 107,484,852 bp 终止 107,490,482 bp
基因位置（小鼠） 染色体 小鼠4号染色体 基因座 4 B3|4 29.76 cM 起始 55,527,143 bp 终止 55,532,466 bp
RNA表达模式 Bgee 人类 小鼠（直系同源） Top expressed in skin of thigh skin of hip mucosa of sigmoid colon skin of arm skin of abdomen jejunal mucosa mucosa of pharynx Top expressed in epithelium of stomach mucous cell of stomach skin of external ear conjunctival fornix left colon pyloric antrum 查阅更多表达数据 BioGPS 查阅更多表达数据
基因本體 分子功能 DNA结合 sequence-specific DNA binding beta-catenin binding phosphatidylinositol 3-kinase regulator activity DNA结合转录因子活性 鋅離子結合 DNA-binding transcription activator activity, RNA polymerase II-specific 转录因子结合 核心启动子近端区域序列特异性DNA结合 金屬離子結合 RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity 血浆蛋白结合 nucleic acid binding double-stranded DNA binding promoter-specific chromatin binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription coregulator binding histone deacetylase binding 細胞組分 細胞質 轉錄調節複合物 核质 染色质 细胞核 生物學過程 negative regulation of chemokine (C-X-C motif) ligand 2 production epidermal cell differentiation cellular response to retinoic acid negative regulation of protein kinase B signaling negative regulation of muscle hyperplasia 平滑肌細胞增殖的負調控 positive regulation of protein metabolic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of axon regeneration cellular response to peptide regulation of transcription, DNA-templated positive regulation of hemoglobin biosynthetic process response to retinoic acid somatic stem cell population maintenance cellular response to laminar fluid shear stress regulation of transcription by RNA polymerase II 细胞分化 epidermis morphogenesis positive regulation of nitric oxide biosynthetic process cellular response to growth factor stimulus cellular response to organic cyclic compound post-embryonic hemopoiesis negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II response to organic substance negative regulation of gene expression negative regulation of response to cytokine stimulus transcription, DNA-templated negative regulation of DNA-binding transcription factor activity negative regulation of phosphatidylinositol 3-kinase signaling stem cell population maintenance negative regulation of cell migration involved in sprouting angiogenesis positive regulation of gene expression negative regulation of cell migration regulation of cell population proliferation post-embryonic camera-type eye development regulation of phosphatidylinositol 3-kinase activity positive regulation of telomerase activity canonical Wnt signaling pathway negative regulation of ERK1 and ERK2 cascade regulation of cell differentiation mesodermal cell fate determination negative regulation of heterotypic cell-cell adhesion negative regulation of transcription, DNA-templated negative regulation of NF-kappaB transcription factor activity cellular response to cycloheximide negative regulation of inflammatory response fat cell differentiation positive regulation of transcription by RNA polymerase II negative regulation of cell population proliferation cellular response to hydrogen peroxide negative regulation of leukocyte adhesion to arterial endothelial cell positive regulation of core promoter binding cellular response to leukemia inhibitory factor negative regulation of angiogenesis pri-miRNA transcription by RNA polymerase II negative regulation of G1/S transition of mitotic cell cycle positive regulation of transcription, DNA-templated positive regulation of sprouting angiogenesis 来源：Amigo / QuickGO
直系同源 物種 人類 小鼠 Entrez 9314 16600 Ensembl ENSG00000136826 ENSMUSG00000003032 UniProt O43474 Q60793 mRNA序列 NM_001314052 ​NM_004235 NM_010637 蛋白序列 NP_001300981 ​NP_004226 NP_034767 基因位置 Chr 9：107.48 – 107.49 Mb Chr 4：55.53 – 55.53 Mb PubMed查询
维基数据
檢視/編輯人類 檢視/編輯小鼠

Kruppel样因子4（英語：Kruppel-like factor 4，缩写KLF4）或肠富集Krüppel样因子（英語：gut-enriched Krüppel-like factor，缩写GKLF）化学式为：C₂₃₉₉H₃₇₀₇O₇₁₉N₇₀₃S₂₄是锌指转录因子KLF家族的一个成员，后者属于一个较大的SP1样转录因子家族。KLF4参与細胞增殖、细胞分化、细胞凋亡和体细胞重编程的调节。有证据表明KLF4在包括大腸癌在内的一些癌症中是肿瘤抑制基因。与KLF2类似，它在C端有三个C2H2型锌指。它有两个核定位序列指引它定位于细胞核内。在胚胎幹細胞(ESCs)和間充質幹細胞(MSCs)中KLF4是显示多能化的很好标记。

外部链接

• 醫學主題詞表（MeSH）：KLF4+protein,+human
• KLF4 microarray expression results and literature

KLF4引用了美国国家医学图书馆提供的資料，这些資料属于公共领域。