CYP27C1
细胞色素 P450 27C1（cytochrome P450 27C1[3][4]，CYP27C1[5][6]），化学式为 C2426H3796O668N677S14Fe[7]，是细胞色素P450超家族的一员，由CYP27C1基因编码，是定位于许多不同组织线粒体内膜的单加氧酶[8][9]。
CYP27C1在体内的主要功能是将全反式视黄醇（属于维生素A1）转化为全反式3,4-脱氢视黄醛（属于维生素A2）[10]；此外还能催化多种反应，如胆固醇、甾体激素的合成与代谢[11]。
参考文献
[编辑]- ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000186684 – Ensembl, May 2017
- ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Glass SM, Webb SN, Guengerich FP. Binding of cytochrome P450 27C1, a retinoid desaturase, to its accessory protein adrenodoxin. Arch Biochem Biophys. 2021 Dec 15;714:109076. doi: 10.1016/j.abb.2021.109076. Epub 2021 Oct 31. PMID: 34732331; PMCID: PMC8629852.
- ^ Glass SM, Tateishi Y, Guengerich FP, Wang HJ. 3,4-Desaturation of retinoic acid by cytochrome P450 27C1 prevents P450-mediated catabolism. Arch Biochem Biophys. 2023 Jul 15;743:109669. doi: 10.1016/j.abb.2023.109669. Epub 2023 Jun 24. PMID: 37356607; PMCID: PMC11500474.
- ^ Enright JM, Toomey MB, Sato SY, et al. Cyp27c1 Red-Shifts the Spectral Sensitivity of Photoreceptors by Converting Vitamin A1 into A2. Curr Biol. 2015 Dec 7;25(23):3048-57. doi: 10.1016/j.cub.2015.10.018. Epub 2015 Nov 5. PMID: 26549260; PMCID: PMC4910640.
- ^ Morshedian A, Toomey MB, Pollock GE, et al. Cambrian origin of the CYP27C1-mediated vitamin A1-to-A2 switch, a key mechanism of vertebrate sensory plasticity. R Soc Open Sci. 2017 Jul 5;4(7):170362. doi: 10.1098/rsos.170362. PMID: 28791166; PMCID: PMC5541561.
- ^ Expasy - ProtParam. web.expasy.org. [2026-01-05].
- ^ Ota T, Suzuki Y, Nishikawa T, et al. Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. January 2004, 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285
.
- ^ Gerhard DS, Wagner L, Feingold EA, et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. October 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- ^ Kramlinger, VM; Nagy, LD; Fujiwara, R; Johnson, KM; Phan, TT; Xiao, Y; Enright, JM; Toomey, MB; Corbo, JC; Guengerich, FP. Human cytochrome P450 27C1 catalyzes 3,4-desaturation of retinoids.. FEBS letters. 2016-05, 590 (9): 1304–12. PMID 27059013. doi:10.1002/1873-3468.12167.
- ^ Entrez Gene: CYP39A1. （原始内容存档于2010-12-05）.
外部链接
[编辑]- 醫學主題詞表（MeSH）：Cytochrome+P-450+CYP27C1
- Human CYP27C1 genome location and CYP27C1 gene details page in the UCSC Genome Browser.