CD18

CD18
已知的结构 PDB 直系同源搜索：PDBe RCSB PDBID列表 1L3Y、1YUK、2JF1、2P26、2P28、3K6S、3K71、3K72、2V7D、4NEH、4NEN、5E6X、5E6V、5E6S、5E6R、5E6W、5ES4、5E6U
标识符
代号	ITGB2
扩展标识	OMIM：600065；MGI：96611；HomoloGene：20092；GeneCards：ITGB2；OMA：ITGB2 - orthologs
基因位置（人类） 染色体 21号染色体 基因座 21q22.3 起始 44,885,953 bp 终止 44,931,989 bp
基因位置（小鼠） 染色体 小鼠10号染色体 基因座 10 C1|10 39.72 cM 起始 77,366,086 bp 终止 77,401,542 bp
RNA表达模式 Bgee 人类 小鼠（直系同源） Top expressed in right lung upper lobe of left lung Top expressed in stroma of bone marrow tibiofemoral joint right lung lobe ankle joint subcutaneous adipose tissue 查阅更多表达数据 BioGPS 查阅更多表达数据
基因本体 分子功能 大分子复合物结合 金属离子结合 血浆蛋白结合 protein heterodimerization activity ICAM-3 receptor activity protein kinase binding cell adhesion molecule binding heat shock protein binding amyloid-beta binding complement component C3b binding integrin binding signaling receptor activity cargo receptor activity 细胞组分 integral component of membrane 细胞外囊泡 integrin alphaL-beta2 complex 膜 细胞膜 receptor complex cell surface integrin complex 外排体 specific granule membrane tertiary granule membrane ficolin-1-rich granule membrane 粘着斑 external side of plasma membrane integrin alphaM-beta2 complex plasma membrane raft 脂筏模型 cytoplasmic region 大分子复合体 生物学过程 leukocyte cell-cell adhesion endodermal cell differentiation toll-like receptor 4 signaling pathway positive regulation of nitric oxide biosynthetic process heterotypic cell-cell adhesion cell-cell signaling 老化 receptor internalization leukocyte migration involved in inflammatory response natural killer cell activation cellular response to low-density lipoprotein particle stimulus extracellular matrix organization receptor clustering positive regulation of angiogenesis neutrophil chemotaxis 细胞粘附 positive regulation of NF-kappaB transcription factor activity regulation of cell shape regulation of immune response cellular extravasation integrin-mediated signaling pathway cell-matrix adhesion inflammatory response endothelial cell migration leukocyte migration regulation of peptidyl-tyrosine phosphorylation 细胞凋亡 吞噬作用 neutrophil degranulation microglial cell activation 受体介导的内吞作用 phagocytosis, engulfment 细胞迁移 cytokine-mediated signaling pathway positive regulation of superoxide anion generation cell adhesion mediated by integrin positive regulation of neutrophil degranulation negative regulation of dopamine metabolic process positive regulation of protein targeting to membrane amyloid-beta clearance cell-cell adhesion cell-cell adhesion via plasma-membrane adhesion molecules positive regulation of neuron death positive regulation of microglial cell activation neutrophil migration positive regulation of prostaglandin-E synthase activity positive regulation of leukocyte adhesion to vascular endothelial cell 来源：Amigo / QuickGO
直系同源 物种 人类 小鼠 Entrez 3689 16414 Ensembl ENSG00000160255 ENSMUSG00000000290 UniProt P05107 P11835 mRNA序列 ​NM_000211 ​NM_001127491 ​NM_001303238 NM_008404 蛋白序列 NP_000202 ​NP_001120963 ​NP_001290167 NP_032430 基因位置 Chr 21：44.89 – 44.93 Mb Chr 10：77.37 – 77.4 Mb PubMed查询
维基数据
查看/编辑人类 查看/编辑小鼠

整联蛋白β-2（英语：Integrin beta-2，CD18）是一个由人类基因 ITGB2 编码的蛋白质，是整联蛋白的一种β亚基。

能与下列四种整联蛋白α亚基搭配形成四种整联蛋白：

• 淋巴球功能性抗原1，LFA-1 (搭配 CD11a)
• 巨噬细胞抗原的1 (搭配 CD11b)
• 整联蛋白αXβ2 (搭配 CD11c)
• 整联蛋白αDβ2 (搭配 CD11d)

相互作用

CD18已经与下列蛋白质进行交互作用 ：

• FHL2
• GNB2L1
• ICAM-1
• PSCD1

外部链接

• MeSH（医学主题词）
  上面的CD18+antigen
• ITGB2 信息的链接在 单元的移徙网关
• Human ITGB2 genome location and ITGB2 gene details page in the UCSC Genome Browser.