CD1A

CD1A
已知的结构 PDB 人类UniProt搜索：PDBe RCSB PDBID列表 1ONQ、1XZ0、4X6C、4X6D、4X6E、4X6F
标识符
代号	CD1A
扩展标识	OMIM：188370；HomoloGene：113556；GeneCards：CD1A；OMA：CD1A - orthologs
基因位置（人类） 染色体 1号染色体 基因座 1q23.1 起始 158,254,424 bp 终止 158,258,269 bp
RNA表达模式 Bgee 人类 小鼠（直系同源） Top expressed in skin of thigh skin of hip skin of arm gingival epithelium skin of abdomen 无数据 查阅更多表达数据 BioGPS 查阅更多表达数据
基因本体 分子功能 beta-2-microglobulin binding endogenous lipid antigen binding 血浆蛋白结合 exogenous lipid antigen binding lipopeptide binding 细胞组分 integral component of membrane 脂筏模型 核内体 integral component of plasma membrane endosome membrane 膜 细胞膜 cell surface 细胞外空间 external side of plasma membrane 生物学过程 antigen processing and presentation, exogenous lipid antigen via MHC class Ib 适应性免疫 immune system process 免疫反应 regulation of immune response positive regulation of T cell mediated cytotoxicity antigen processing and presentation, endogenous lipid antigen via MHC class Ib 来源：Amigo / QuickGO
直系同源 物种 人类 小鼠 Entrez 909 无数据 Ensembl ENSG00000158477 无数据 UniProt P06126 无数据 mRNA序列 NM_001763 ​NM_001320652 无数据 蛋白序列 NP_001307581 ​NP_001754 无数据 基因位置 Chr 1：158.25 – 158.26 Mb 无数据 PubMed查询 无数据
维基数据
查看/编辑人类

CD1a（Cluster of Differentiation 1a）是身上的一种人类蛋白质，由基因“CD1A”转译而成。

该蛋白属于CD1蛋白家族，为一种穿膜糖蛋白。CD1a与β2-微球蛋白共同构成的异源二聚体（heterodimers）称为“CD1a复合体”（CD1a complex），在结构上类似MHC I分子。两者都具有抗原呈现的能力，但CD1a主要呈现的是糖脂类，而MHC分子主要呈现的是多肽类。人类身上的CD1家族基因共有五个，且都集中排列在1号染色体上的某个区域。

临床意义

在抽烟的病人身上，“CD1A”在肺间质的表现会较为显著。

外部链接

• Human CD1A genome location and CD1A gene details page in the UCSC Genome Browser.
• PDB中UniProt可用的所有结构信息之概述：P06126 (Human T-cell surface glycoprotein CD1a) 在PDBe-KB。

延伸阅读

• Melián A, Beckman EM, Porcelli SA, Brenner MB. Antigen presentation by CD1 and MHC-encoded class I-like molecules.. Curr. Opin. Immunol. 1996, 8 (1): 82–8. PMID 8729450. doi:10.1016/S0952-7915(96)80109-9. 
• Park SH, Bendelac A. CD1-restricted T-cell responses and microbial infection.. Nature. 2000, 406 (6797): 788–92. PMID 10963609. S2CID 4373172. doi:10.1038/35021233. 
• Brigl M, Brenner MB. CD1: antigen presentation and T cell function.. Annu. Rev. Immunol. 2004, 22 (1): 817–90. PMID 15032598. doi:10.1146/annurev.immunol.22.012703.104608. 
• Coventry B, Heinzel S. CD1a in human cancers: a new role for an old molecule.. Trends Immunol. 2004, 25 (5): 242–8. PMID 15099564. doi:10.1016/j.it.2004.03.002. 
• Moody DB, Zajonc DM, Wilson IA. Anatomy of CD1-lipid antigen complexes.. Nat. Rev. Immunol. 2005, 5 (5): 387–99. PMID 15864273. S2CID 1387491. doi:10.1038/nri1605. 
• Stove V, Verhasselt B. Modelling thymic HIV-1 Nef effects.. Curr. HIV Res. 2006, 4 (1): 57–64. PMID 16454711. doi:10.2174/157016206775197583. 
• Quaranta MG, Mattioli B, Giordani L, Viora M. The immunoregulatory effects of HIV-1 Nef on dendritic cells and the pathogenesis of AIDS.. FASEB J. 2006, 20 (13): 2198–208. PMID 17077296. S2CID 3111709. doi:10.1096/fj.06-6260rev. 
• Oakey RJ, Watson ML, Seldin MF. Construction of a physical map on mouse and human chromosome 1: comparison of 13 Mb of mouse and 11 Mb of human DNA.. Hum. Mol. Genet. 1993, 1 (8): 613–20. PMID 1301170. doi:10.1093/hmg/1.8.613. 
• Martin LH, Calabi F, Lefebvre FA, et al. Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c.. Proc. Natl. Acad. Sci. U.S.A. 1988, 84 (24): 9189–93. PMC 299718 . PMID 2447586. doi:10.1073/pnas.84.24.9189 . 
• Moseley WS, Watson ML, Kingsmore SF, Seldin MF. CD1 defines conserved linkage group border between human chromosomes 1 and mouse chromosomes 1 and 3.. Immunogenetics. 1989, 30 (5): 378–82. PMID 2478463. S2CID 9361881. doi:10.1007/BF02425278. 
• Yu CY, Milstein C. A physical map linking the five CD1 human thymocyte differentiation antigen genes.. EMBO J. 1990, 8 (12): 3727–32. PMC 402056 . PMID 2583117. doi:10.1002/j.1460-2075.1989.tb08548.x. 
• Aruffo A, Seed B. Expression of cDNA clones encoding the thymocyte antigens CD1a, b, c demonstrates a hierarchy of exclusion in fibroblasts.. J. Immunol. 1989, 143 (5): 1723–30. PMID 2701945. S2CID 23168239. doi:10.4049/jimmunol.143.5.1723. 
• Longley J, Kraus J, Alonso M, Edelson R. Molecular cloning of CD1a (T6), a human epidermal dendritic cell marker related to class I MHC molecules.. J. Invest. Dermatol. 1989, 92 (4): 628–31. PMID 2784820. doi:10.1111/1523-1747.ep12712175 . 
• Albertson DG, Fishpool R, Sherrington P, et al. Sensitive and high resolution in situ hybridization to human chromosomes using biotin labelled probes: assignment of the human thymocyte CD1 antigen genes to chromosome 1.. EMBO J. 1988, 7 (9): 2801–5. PMC 457071 . PMID 3053166. doi:10.1002/j.1460-2075.1988.tb03135.x. 
• Calabi F, Milstein C. A novel family of human major histocompatibility complex-related genes not mapping to chromosome 6.. Nature. 1986, 323 (6088): 540–3. Bibcode:1986Natur.323..540C. PMID 3093894. S2CID 4274219. doi:10.1038/323540a0. 
• Martin LH, Calabi F, Milstein C. Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens.. Proc. Natl. Acad. Sci. U.S.A. 1987, 83 (23): 9154–8. PMC 387093 . PMID 3097645. doi:10.1073/pnas.83.23.9154 . 
• Woolfson A, Milstein C. Alternative splicing generates secretory isoforms of human CD1.. Proc. Natl. Acad. Sci. U.S.A. 1994, 91 (14): 6683–7. Bibcode:1994PNAS...91.6683W. PMC 44267 . PMID 7517559. doi:10.1073/pnas.91.14.6683 . 
• Han M, Hannick LI, DiBrino M, Robinson MA. Polymorphism of human CD1 genes.. Tissue Antigens. 2000, 54 (2): 122–7 [2023-06-03]. PMID 10488738. doi:10.1034/j.1399-0039.1999.540202.x. （原始内容存档于2023-04-11）. 
• Sugita M, Grant EP, van Donselaar E, et al. Separate pathways for antigen presentation by CD1 molecules.. Immunity. 2000, 11 (6): 743–52. PMID 10626896. doi:10.1016/S1074-7613(00)80148-X . 

CD1A引用了美国国家医学图书馆提供的资料，这些资料属于公共领域。