TLR4

TLR4
已知的結構 PDB 直系同源搜尋：PDBe RCSB PDBID列表 4G8A、2Z62、2Z63、2Z65、2Z66、3FXI、3UL7、3UL8、3UL9、3ULA
標識符
代號	TLR4
擴展標識	OMIM：603030；MGI：96824；HomoloGene：41317；GeneCards：TLR4；OMA：TLR4 - orthologs
基因位置（人類） 染色體 9號染色體 基因座 9q33.1 起始 117,704,175 bp 終止 117,724,735 bp
基因位置（小鼠） 染色體 小鼠4號染色體 基因座 4 C1|4 34.66 cM 起始 66,745,821 bp 終止 66,848,521 bp
RNA表達模式 Bgee 人類 小鼠（直系同源） Top expressed in right lung Top expressed in lumbar spinal ganglion epithelium of stomach stroma of bone marrow endothelial cell of lymphatic vessel mucous cell of stomach 查閱更多表達數據 BioGPS 查閱更多表達數據
基因本體 分子功能 lipopolysaccharide immune receptor activity lipopolysaccharide binding 血漿蛋白結合 transmembrane signaling receptor activity 細胞組分 細胞質 膜 細胞質的核周區域 cell surface integral component of membrane 細胞膜 endosome membrane intrinsic component of plasma membrane integral component of plasma membrane lipopolysaccharide receptor complex external side of plasma membrane 生物學過程 positive regulation of MHC class II biosynthetic process positive regulation of JNK cascade TRIF-dependent toll-like receptor signaling pathway cellular response to mechanical stimulus positive regulation of interleukin-8 production positive regulation of ERK1 and ERK2 cascade T-helper 1 type immune response positive regulation of platelet activation positive regulation of interleukin-1 production positive regulation of stress-activated MAPK cascade positive regulation of NLRP3 inflammasome complex assembly positive regulation of interleukin-12 production positive regulation of interferon-alpha production I-kappaB phosphorylation positive regulation of nitric-oxide synthase biosynthetic process positive regulation of B cell proliferation defense response to bacterium positive regulation of interleukin-6 production activation of innate immune response positive regulation of tumor necrosis factor production 腫瘤壞死因子產生的負調控 先天免疫系統 negative regulation of interleukin-17 production I-kappaB kinase/NF-kappaB signaling positive regulation of interferon-beta production positive regulation of inflammatory response toll-like receptor 4 signaling pathway positive regulation of macrophage cytokine production positive regulation of interleukin-10 production immune system process astrocyte development intestinal epithelial structure maintenance positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway response to lipopolysaccharide cellular response to lipoteichoic acid positive regulation of NF-kappaB transcription factor activity 免疫反應 negative regulation of interleukin-23 production regulation of inflammatory response positive regulation of chemokine production lipopolysaccharide-mediated signaling pathway detection of fungus positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway negative regulation of interferon-gamma production response to bacterium negative regulation of osteoclast differentiation B cell proliferation involved in immune response positive regulation of nitric oxide biosynthetic process negative regulation of interleukin-6 production positive regulation of interferon-gamma production nitric oxide production involved in inflammatory response MyD88-dependent toll-like receptor signaling pathway regulation of dendritic cell cytokine production positive regulation of gene expression negative regulation of ERK1 and ERK2 cascade positive regulation of I-kappaB kinase/NF-kappaB signaling macrophage activation detection of lipopolysaccharide cellular response to lipopolysaccharide positive regulation of lymphocyte proliferation positive regulation of transcription by RNA polymerase II MyD88-independent toll-like receptor signaling pathway 信號轉導 inflammatory response defense response to Gram-negative bacterium toll-like receptor signaling pathway 程式性壞死 apoptotic signaling pathway negative regulation of MyD88-independent toll-like receptor signaling pathway 來源：Amigo / QuickGO
直系同源 物種 人類 小鼠 Entrez 7099 21898 Ensembl ENSG00000136869 ENSMUSG00000039005 UniProt O00206 Q9QUK6 mRNA序列 NM_138557 ​NM_003266 ​NM_138554 ​NM_138556 NM_021297 蛋白序列 NP_003257 ​NP_612564 ​NP_612567 NP_067272 基因位置 Chr 9：117.7 – 117.72 Mb Chr 4：66.75 – 66.85 Mb PubMed查詢
維基數據
檢視/編輯人類 檢視/編輯小鼠

Toll樣受體4（英語：Toll-like receptor 4）是由人類基因 TLR4 編碼的蛋白質，是一種膜蛋白質，也被稱為CD284（分化簇284，cluster of differentiation 284），是模式識別受體中Toll樣受體（TLR）家族的成員，可結合其配體脂多糖（LPS）活化NF-κB信號通路，在先天免疫系統中起到重要作用。

外部連結

• 醫學主題詞表（MeSH）：Toll-Like+Receptor+4
• PDB中UniProt可用的所有結構資訊之概述：O00206 (Toll-like receptor 4) 在PDBe-KB。