CD61

CD61
已知的结构 PDB 直系同源搜索：PDBe RCSB PDBID列表 4O02、1JV2、1KUP、1KUZ、1L5G、1M1X、1M8O、1MIZ、1MK7、1MK9、1S4X、1TYE、1U8C、2K9J、2KNC、2KV9、2L1C、2L91、2LJD、2LJE、2LJF、2MTP、2Q6W、2RMZ、2RN0、2VC2、2VDK、2VDL、2VDM、2VDN、2VDP、2VDQ、2VDR、3FCS、3FCU、3IJE、3NID、3NIF、3NIG、3T3M、3T3P、3ZDX、3ZDY、3ZDZ、3ZE0、3ZE1、3ZE2、4CAK、4G1E、4G1M、4MMX、4MMY、4MMZ、5HDB、4Z7Q、4Z7O、4Z7N
标识符
代号	ITGB3
扩展标识	OMIM：173470；MGI：96612；HomoloGene：55444；GeneCards：ITGB3；OMA：ITGB3 - orthologs
基因位置（人类） 染色体 17号染色体 基因座 17q21.32 起始 47,253,827 bp 终止 47,313,743 bp
基因位置（小鼠） 染色体 小鼠11号染色体 基因座 11 E1|11 67.84 cM 起始 104,498,826 bp 终止 104,561,302 bp
RNA表达模式 Bgee 人类 小鼠（直系同源） Top expressed in Descending thoracic aorta right lobe of thyroid gland left lobe of thyroid gland tendon of biceps brachii tibial arteries Top expressed in endothelial cell of lymphatic vessel superior surface of tongue 查阅更多表达数据 BioGPS 查阅更多表达数据
基因本体 分子功能 vascular endothelial growth factor receptor 2 binding fibronectin binding virus receptor activity extracellular matrix binding protein disulfide isomerase activity 蛋白酶结合 platelet-derived growth factor receptor binding 血浆蛋白结合 相同蛋白质结合 酶结合 cell adhesion molecule binding neuregulin binding coreceptor activity fibroblast growth factor binding insulin-like growth factor I binding C-X3-C chemokine binding integrin binding fibrinogen binding 细胞组分 integral component of membrane cell projection alphav-beta3 integrin-vitronectin complex 膜 粘着斑 黑色素体 receptor complex 细胞膜 integral component of plasma membrane ruffle membrane cell surface 细胞连接 integrin complex platelet alpha granule membrane integrin alphav-beta3 complex 外排体 lamellipodium membrane 细胞核 microvillus membrane filopodium membrane alphav-beta3 integrin-IGF-1-IGF1R complex alphav-beta3 integrin-PKCalpha complex alphav-beta3 integrin-HMGB1 complex glutamatergic synapse 突触 生物学过程 negative regulation of lipoprotein metabolic process apolipoprotein A-I-mediated signaling pathway positive regulation of vascular endothelial growth factor receptor signaling pathway positive regulation of protein phosphorylation regulation of cell migration negative chemotaxis positive regulation of endothelial cell proliferation tube development heterotypic cell-cell adhesion angiogenesis involved in wound healing 伤口愈合 platelet degranulation 凝血 extracellular matrix organization smooth muscle cell migration positive regulation of endothelial cell migration 增殖 cell-substrate adhesion vascular endothelial growth factor receptor signaling pathway 细胞粘附 positive regulation of peptidyl-tyrosine phosphorylation mesodermal cell differentiation cell-substrate junction assembly integrin-mediated signaling pathway negative regulation of lipid storage substrate adhesion-dependent cell spreading negative regulation of lipid transport cell-matrix adhesion viral process regulation of bone resorption platelet aggregation 细胞迁移 negative regulation of macrophage derived foam cell differentiation activation of protein kinase activity leukocyte migration cell adhesion mediated by integrin platelet activation apoptotic cell clearance regulation of postsynaptic neurotransmitter receptor internalization regulation of protein localization regulation of serotonin uptake 来源：Amigo / QuickGO
直系同源 物种 人类 小鼠 Entrez 3690 16416 Ensembl ENSG00000259207 ENSMUSG00000020689 UniProt P05106 O54890 mRNA序列 NM_000212 NM_016780 蛋白序列 NP_000203 NP_058060 基因位置 Chr 17：47.25 – 47.31 Mb Chr 11：104.5 – 104.56 Mb PubMed查询
维基数据
查看/编辑人类 查看/编辑小鼠

整联蛋白β-3（Integrin β3）或 CD61（Cluster of differentiation 61）是一种蛋白质 ，在人类基因组中由 ITGB3 基因编码。CD61 是一种在血小板上表达的分化簇。

扩展阅读

• Bray PF. Inherited diseases of platelet glycoproteins: considerations for rapid molecular characterization.. Thromb. Haemost. 1995, 72 (4): 492–502. PMID 7878622. 
• Bennett JS. Platelet-fibrinogen interactions.. Ann. N. Y. Acad. Sci. 2001, 936: 340–54. Bibcode:2001NYASA.936..340B. PMID 11460491. doi:10.1111/j.1749-6632.2001.tb03521.x. 
• Sajid M, Stouffer GA. The role of alpha(v)beta3 integrins in vascular healing.. Thromb. Haemost. 2002, 87 (2): 187–93. PMID 11858476. 
• Quinn MJ, Byzova TV, Qin J, et al. Integrin alphaIIbbeta3 and its antagonism.. Arterioscler. Thromb. Vasc. Biol. 2004, 23 (6): 945–52. PMID 12637342. doi:10.1161/01.ATV.0000066686.46338.F1. 
• Charakida M, Tousoulis D, Stefanadis C, Toutouzas P. The impact of platelet glycoprotein IIIa and Ia polymorphisms in cardiovascular thrombotic disease.. Italian Heart Journal. 2003, 4 (1): 17–22. PMID 12690916. 
• Smith FB, Connor JM, Lee AJ, et al. Relationship of the platelet glycoprotein PlA and fibrinogen T/G+1689 polymorphisms with peripheral arterial disease and ischaemic heart disease.. Thromb. Res. 2004, 112 (4): 209–16. PMID 14987913. doi:10.1016/j.thromres.2003.11.010. 
• Fullard JF. The role of the platelet glycoprotein IIb/IIIa in thrombosis and haemostasis.. Curr. Pharm. Des. 2004, 10 (14): 1567–76. PMID 15134555. doi:10.2174/1381612043384682. 
• Cacciari B, Spalluto G. Non peptidic alphavbeta3 antagonists: recent developments.. Curr. Med. Chem. 2005, 12 (1): 51–70. PMID 15638730. doi:10.2174/0929867053363522. 
• Watson SP, Auger JM, McCarty OJ, Pearce AC. GPVI and integrin alphaIIb beta3 signaling in platelets.. J. Thromb. Haemost. 2005, 3 (8): 1752–62. PMID 16102042. doi:10.1111/j.1538-7836.2005.01429.x. 
• Bennett JS. Structure and function of the platelet integrin alphaIIbbeta3.. J. Clin. Invest. 2006, 115 (12): 3363–9. PMC 1297263 . PMID 16322781. doi:10.1172/JCI26989. 

外部链接

• 医学主题词表（MeSH）：CD61+Antigens
• ITGB3 信息的链接在 单元的移徙网关
• Human ITGB3 genome location and ITGB3 gene details page in the UCSC Genome Browser.